Dietary fucoidan modulates the gut microbiota in mice by increasing the abundance ofLactobacillusandRuminococcaceae

Abstract

Recently, fucoidan has been proposed as a potential prebiotic agent for functional food and pharmaceutical development. However, while previous studies illustrated favorable modulations of gut microbiota by fucoidan, changes in the overall microbial structure remain elusive. In the present study, modulations of gut microbiota by different fucoidans were studied using high throughput sequencing and bioinformatics analysis. We found that at the expense of opportunistic pathogenic bacteria such as Peptococcus, the abundance of beneficial bacteria including Lactobacillus and Ruminococcaceae was significantly increased in response to fucoidan treatment. Besides, by maintaining a more balanced composition of gut microbiota, dietary fucoidan also significantly reduced the antigen load and the inflammatory response in the host as evidenced by the decreased serum lipopolysaccharide-binding protein levels. Collectively, our results indicate that fucoidan can be used as a gut microbiota modulator for health promotion and treatment of intestinal dysbiosis.

Anti-Inflammatory Effects of Huangqin Decoction on Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice Through Regulation of the Gut Microbiota and Suppression of the Ras-PI3K-Akt-HIF-1α and NF-κB Pathways

“…In contrast, HQD promoted recovery of the diversity of the gut microbiota, and regulated the populations of beneficial bacteria and pathogenic bacteria, as evidenced by higher levels of Bacteroides, Lactobacillus, Prevotellaceae, and Blautia, and lower levels of Epsilonproteobacteria, Deltaproteobacteria, and Helicobacter. Ruminococcus is regarded as a benign bacteria, and was inversely correlated with intestinal permeability in a previous study (Shang et al, 2016). In our study, the relative abundance of Ruminococcus in the DSS group was higher than that in the HQD group.…”

Soluble Dietary Fiber Reduces Trimethylamine Metabolism via Gut Microbiota and Co‐Regulates Host AMPK Pathways

“…For example, degradation of these specific polysaccharides by the gut microbiota involves the production of specific enzymes, such as xylanases, arabinoxylanases, and β‐glucanases . In addition, these pentosans differ in molecular weight and substitution degree (arabinose/xylose), which may also exert different modulatory effects on gut microbiota . Since gut microbiota fermentation may depend on the structure and size of the SDF molecules.…”

“…[37,38] In addition, these pentosans differ in molecular weight and substitution degree (arabinose/xylose), which may also exert different modulatory effects on gut microbiota. [39] Since gut microbiota fermentation may depend on the structure and size of the SDF molecules.…”

Positive effects of dietary supplementation of three probiotics on milk yield, milk composition and intestinal flora in Sannan dairy goats varied in kind of probiotics

“…Some studies have suggested that Christensenellaceae participate in positive regulation of the intestinal environment and are linked to immunomodulation and healthy homeostasis (Kong et al, 2016;Shang et al, 2016). Some studies have suggested that Christensenellaceae participate in positive regulation of the intestinal environment and are linked to immunomodulation and healthy homeostasis (Kong et al, 2016;Shang et al, 2016).…”

“…There were some differences in gut bacterial community compo- and could be as a reason for the increased DMI, milk yield and improved milk composition as discussed previously. Some studies have suggested that Christensenellaceae participate in positive regulation of the intestinal environment and are linked to immunomodulation and healthy homeostasis (Kong et al, 2016;Shang et al, 2016).…”