Dietary Folate and the Risk of Depression in Finnish Middle-Aged Men

Tolmunen, Tommi; Hintikka, Jukka; Ruusunen, Anu; Voutilainen, Sari; Tanskanen, Antti; Valkonen, Veli-Pekka; Viinamäki, Heimo; Kaplan, George A.; Salonen, Jukka T.

doi:10.1159/000080385

Cited by 127 publications

(117 citation statements)

References 44 publications

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“…[77] Aleksitimi skorlarının, klinik popülasyon-dakine kıyasla, klinik olmayan popülasyonda daha istikrarlı olması da bu bilgi ile tutarlı görünmektedir. [78][79][80] Ne var ki, aleksitiminin uzun süreli/kalıcı bir özellik mi yoksa geçici bir durum mu olduğu günümüzde hala netliğe kavuşamamış bir konudur.…”

Section: Aleksitimi Kavramıyla İlgili Sorgulamalar Ve Yeni Açılımlarunclassified

The Concept of Alexithymia

Şaşıoğlu¹,

Gülol²,

Tosun³

2013

Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychia

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ÖZET"Duygular için söz yokluğu" anlamına gelen ve psikiyatri çevrelerince hızla kabul görmüş bir kavram olan aleksitimi, başlangıçta psikosomatik hastalardaki belirtileri açıklamak için ortaya atılmıştır. Ancak güncel çalışmalar aleksitiminin birçok farklı patolojik grupta ve hatta sağlıklı popülasyonda da karşımı-za çıkan bir kişilik özelliği olabileceğini ortaya koymuştur. Bu noktada aleksitimi kavramının var olan yapı ve tanılardan ayrılması ve gerek kuramsal gerekse ölçümsel anlamda güvenirlik ve geçerliğine yönelik soru işaretlerinin ortadan kalkması için birçok araştırma yapılmıştır. Bu kuramsal derleme çalışma-sında da, kavram üzerinde süre giden tartışmaların günümüzde ne noktada olduğu sorusuna yanıt aranmaktadır. Bu bağlamda, aleksitimi kavramı; özel-likleri, kuramsal temelleri, diğer bozukluklarla ilişkisi ve ölçümü boyutlarında incelenmekte; hem ölçüme hem de kavrama yönelik eleştiriler ele alınmıştır. Anahtar Sözcükler: Aleksitimi, patoloji, nörofizyoloji, psikanaliz. ABSTRACTThe concept of alexithymia, which means "no words for emotions", emerged in order to explain the symptoms of psychosomatic patients and gained a quick recognition among psychiatrists. However, current studies indicate that alexithymia may be a personality trait seen both in different pathological groups and even in healthy population. At this point, many researches have been made in order to distinguish alexithymia from existing constructs and diagnosis, and to remove the questions on reliability and validity of the concept and its measurement. Ongoing discussions on alexithymia will be reviewed in this study. The controversial concept of alexithymia will be examined in terms of characteristics, theoretical background, relationship with the other disorders, measurement and the critique of the measurement and the concept.

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Section: Aleksitimi Kavramıyla İlgili Sorgulamalar Ve Yeni Açılımlarunclassified

The Concept of Alexithymia

Şaşıoğlu¹,

Gülol²,

Tosun³

2013

Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychia

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“…In a large Finnish study, depressed patients in the general population with energy-adjusted folate intake below the median had a higher risk of getting a discharge diagnosis of depression during the followup period than those who had a folate intake above the median. A low dietary intake of folate may be a risk factor for severe depression (Tolmunen et al 2004). There has been some discussion in the recent literature regarding the possible relationship between peripheral levels of folate and serotonin deficiency in the CNS.…”

Section: Vitamins: Folic Acidmentioning

confidence: 99%

Consensus paper of the WFSBP Task Force on Biological Markers: Biological Markers in Depression

Mößner

Mikova

Koutsilieri

et al. 2007

The World Journal of Biological Psychiatry

226

125

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Biological markers for depression are of great interest to aid in elucidating the causes of major depression. We assess currently available biological markers to query their validity for aiding in the diagnosis of major depression. We specifically focus on neurotrophic factors, serotonergic markers, biochemical markers, immunological markers, neuroimaging, neurophysiological findings, and neuropsychological markers. We delineate the most robust biological markers of major depression. These include decreased platelet imipramine binding, decreased 5-HT1A receptor expression, increase of soluble interleukin-2 receptor and interleukin-6 in serum, decreased brain-derived neurotrophic factor in serum, hypocholesterolemia, low blood folate levels, and impaired suppression of the dexamethasone suppression test. To date, however, none of these markers are sufficiently specific to contribute to the diagnosis of major depression. Thus, with regard to new diagnostic manuals such as DSM-V and ICD-11 which are currently assessing whether biological markers may be included in diagnostic criteria, no biological markers for major depression are currently available for inclusion in the diagnostic criteria.

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“…Administration of folic acid was also shown to be associated with early recovery from depression (Fava et al, 1997;Taylor et al, 2003), suggesting a therapeutic importance of this nutrient. A protective role of folate in depression has been further supported by various epidemiologic studies, in which either dietary folate intake (Tolmunen et al, 2003(Tolmunen et al, , 2004aSanchez-Villegas et al, 2006;Murakami et al, 2008) or blood folate concentrations (Bjelland et al, 2003;Morris et al, 2003;Ramos et al, 2004;Sachdev et al, 2005;Dimopoulos et al, 2007;Kim et al, 2008) or SNPs involved in folate metabolism (Gilbody et al, 2007a) was used as the exposure index. In a recent meta-analysis of 11 studies, persons with low levels of serum, low red blood cell or low intake of folate had a 1.4 times increased risk of depressive symptom, compared with those with high folate status (Gilbody et al, 2007b).…”

Section: Introductionmentioning

confidence: 99%

Serum folate and homocysteine and depressive symptoms among Japanese men and women

et al. 2010

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Background/Objectives: Folate and homocysteine have been implicated to have a role in depression. However, results of epidemiologic studies on this issue have been inconsistent. The objective of this study was to clarify the association between serum folate and homocysteine concentrations and depressive symptoms in Japanese adults. Subjects/Methods: We analyzed cross-sectional data for 530 municipal employees (313 men and 217 women), aged 21-67 years, who participated in a health survey at the time of periodic checkup. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression (CES-D) scale. Logistic regression analysis was used to estimate odds ratios of depressive symptoms (CES-D scale scores of X16) with adjustment for potential confounding variables. Results: In total, 113 men (36.1%) and 79 women (36.4%) had depressive symptoms. A higher serum folate was associated with a decreased prevalence of depressive symptoms in men. The multivariate-adjusted odds ratios (95% confidence interval) of depressive symptoms for the lowest to highest quartiles of serum folate were 1.00 (reference), 0.53 (0.27-1.03), 0.33 (0.16-0.68) and 0.51 (0.25-1.03), respectively (trend P ¼ 0.03). Furthermore, the data suggested a positive association between serum homocysteine and depressive symptoms in men (trend P ¼ 0.06). In women, neither folate nor homocysteine was associated with depressive symptoms. Conclusions: Low serum folate may be related to an increased prevalence of depressive symptoms in Japanese men.

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Dietary Folate and the Risk of Depression in Finnish Middle-Aged Men

Cited by 127 publications

References 44 publications

The Concept of Alexithymia

The Concept of Alexithymia

Consensus paper of the WFSBP Task Force on Biological Markers: Biological Markers in Depression

Serum folate and homocysteine and depressive symptoms among Japanese men and women

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