Serum folate and homocysteine and depressive symptoms among Japanese men and women

Nanri, Akiko; Mizoue, Tetsuya; Matsushita, Yushu; Sasaki, Satoshi; Ohta, Masanori; Sato, Masao; Mishima, Nozomu

doi:10.1038/ejcn.2009.143

Cited by 43 publications

(40 citation statements)

References 33 publications

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“…France (Astorg, et al, 2008), Greece (Dimopoulos, et al, 2007), Japan (Murakami, et al, 2008;Nanri, Mizoue, et al, 2010) Norway (Bjelland, et al, 2003), Singapore (Ng, Niti, Zaw, & Kua, 2009), Spain (Sanchez-Villegas, Doreste, et al, 2009Sanchez-Villegas, et al, 2006), and Australia before 2009 (Almeida, et al, 2010;Sachdev et al, 2005). Fortification of flour with folic acid may have attenuated the effect of folate, which corroborates the aforementioned hypothesis that lower vitamin status may be more strongly associated with depression compared to higher vitamin status due to mandatory fortification.…”

Section: Discussionmentioning

confidence: 99%

Nutritional predictors of depression in a cohort of community-dwelling elderly Canadians: NuAge cohort

GougeonLaura¹

2014

Appl. Physiol. Nutr. Metab.

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Depression is associated with decreased quality of life and high mortality risk at all ages and, despite having lower prevalence in community-dwelling seniors compared to other stages of the life span or institutionalized elderly, it negatively affects seniors' health outcomes. Most evidence linking late-life depression, defined as first onset after 65 years of age, with dietary factors comes from cross-sectional studies, which cannot provide information on whether declines in diet were a consequence of depression-the reverse causality hypothesis. The Quebec Longitudinal Study on Nutrition and Aging (NuAge) provides an ideal setting to explore such a relationship among a healthy, community-dwelling elderly population. Diet is hypothesized to be a factor associated with depression. Some longitudinal evidence from studies with middle-aged adults suggests that dietary patterns such as the Mediterranean or patterns deemed "healthy" are protective against depression, while "western" and "unhealthy" patterns are risk factors for the disease. B-vitamins are important cofactors in neurotransmitter synthesis and in the enzymes of the one-carbon metabolism, which has been hypothesized to have an aetiological role in depression through its neurotoxic derivates, such as homocysteine. Nonetheless, it is still largely unknown how depression affects nutrient intake in the elderly population, raising the question of the directionality of the association. Therefore, ii the three objectives of this thesis were to explore the longitudinal associations of i) dietary patterns and macronutrient intake and of ii) B6, B12 and folate intakes with the incidence of depression in late life; and iii) to investigate whether depression significantly affects short-term nutrient intakes (reverse causality effect) in comparison to intakes among non-depressed seniors.Data for this study have been obtained from the NuAge cohort, a 4-y longitudinal study of 1,793 community-dwelling men and women aged 68 to 82 years at baseline. The main outcome is incidence of depression as defined by scores in the 30-item Geriatric Depression Scale ≥11 and or antidepressant medication use over the three years of follow-up. Participants were free of depression at the study's baseline through the exclusion of those with GDS scores ≥11 or antidepressant use at the time of the recruitment. Individuals with invalid or missing dietary information were also excluded. Dietary patterns were created through principal component analysis on amount (grams) of food items consumed in each of the 32 predefined food categories. Sex-specific tertiles of intake were created from the mean of three non-consecutive 24h-recalls. Multiple logistic regression models were adjusted for several demographic, health, and social confounders. For the study of the reverse causality hypothesis, we conducted a case-control nested within the NuAge cohort. Participants free of iii depression at baseline who developed depression at some point of follow-up were matched by age group and sex with...

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Section: Discussionmentioning

confidence: 99%

Nutritional predictors of depression in a cohort of community-dwelling elderly Canadians: NuAge cohort

GougeonLaura¹

2014

Appl. Physiol. Nutr. Metab.

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“…The study procedure has been described in greater details elsewhere (Murakami et al, 2008;Nanri et al, 2010). In brief, the survey was conducted in July and November 2006 among employees working in two municipal offices in northeastern Kyushu, Japan.…”

Section: Study Subjects and Proceduresmentioning

confidence: 99%

Association between serum ferritin concentrations and depressive symptoms in Japanese municipal employees

Nanri

Poudel‐Tandukar

et al. 2011

Psychiatry Research

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a b s t r a c tKeywords: Depressive symptoms, Serum ferritin, Body iron store, General population, JapaneseIt remains unclear whether levels of body iron store are related to milder forms of depression, which are more common among apparently healthy people. We examined the association between serum ferritin concentrations and depressive symptoms among 312 men and 216 women working in two municipal offices in Japan. Depressive symptoms were assessed by using the Center for Epidemiologic Studies Depression (CES-D) scale. In men, increased prevalence of depressive symptoms (defined by using a cutoff value of ≥ 19) was significantly associated with decreased levels of serum ferritin. In age-and study-site-adjusted models, ORs (95% CIs) for depressive symptoms for men in first, second, third, and fourth quartiles of serum ferritin concentrations were 2.83 (1.01-7.94), 1.74 (0.87-3.49), 1.33 (0.71-2.47), and 1.00 (reference), respectively (p for trend = 0.02). In multivariate-adjusted model, ORs (95% CIs) in first, second, third, and fourth quartiles of serum ferritin concentrations were 2.88 (0.93-8.91), 1.91 (0.90-4.05), 1.28 (0.66-2.49), and 1.00 (reference), respectively (p for trend = 0.03). No significant association was detected in women. Our finding that men with lower levels of serum ferritin concentrations had a higher prevalence of depressive symptoms suggests that adverse psychological effects may be implicated in iron deficiency among middle-age Japanese workers.

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“…Previously, the effect of PS on diet (5)(6)(7)(8) and the effect of drinking on diet (10)(11)(12) were investigated separately. In the present study, we fi rst reported the interaction between self-reported PS levels and drinking status in relation to diet.…”

Section: Discussionmentioning

confidence: 99%

“…However, there are few studies of the effect of drinking on diet in Japanese subjects. The effect of PS on diet (5)(6)(7)(8) and the effect of drinking on diet (10)(11)(12) are well documented, but little is known about the combined effect of PS and drinking on diet. Our objective was to investigate interactions between PS levels and drinking status in relation to dietary intake of food and nutrients in a large-scale cross-sectional study of middle-aged Japanese men and women.…”

Section: Interactions Between Psychological Stress and Drinking Statumentioning

confidence: 99%

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Interactions between Psychological Stress and Drinking Status in Relation to Diet among Middle-Aged Men and Women: A Large-Scale Cross-Sectional Study in Japan

Endoh

Kuriki

Kasezawa³

et al. 2015

J Nutr Sci Vitaminol

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SummaryThe aim of this study was to investigate the interaction between psychological stress (PS) and drinking status in relation to diet among middle-aged Japanese men and women in a large-scale cross-sectional study. The study population included 5,587 middleaged Japanese men and 2,718 middle-aged Japanese women who underwent annual health checkups. The subjects were divided into 2 groups (non-drinkers and drinkers) and classifi ed as having low, moderate, or high self-reported PS levels. Energy-adjusted food and nutrient consumption was assessed with a validated food frequency questionnaire. Using a general linear model, food and nutrient consumption was estimated for each self-reported PS level in the 2 groups (non-drinkers and drinkers) and the interactions between self-reported PS levels and drinking status were calculated. In men, pork and beef; squid, octopus, shrimp, and clams; eggs; mushrooms; Japanese-style sweets; ice cream; bread; Chinese noodles; coffee; and soda as foods and protein, animal protein, fat, animal fat, carbohydrate, monounsaturated fatty acid, polyunsaturated fatty acid (PUFA), n-3 PUFA, n-6 PUFA, cholesterol, vitamin D, vitamin B2, vitamin B6, vitamin B12, niacin, pantothenic acid, magnesium, phosphorus, and zinc as nutrients signifi cantly interacted with self-reported PS levels and drinking status (p for interaction Ͻ0.05 for all). No specifi c interactions were found in women. These fi ndings suggest interactions between PS levels and drinking status with consumption of some foods and nutrients, especially macronutrient intake, in men but not in women.

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Serum folate and homocysteine and depressive symptoms among Japanese men and women

Cited by 43 publications

References 33 publications

Nutritional predictors of depression in a cohort of community-dwelling elderly Canadians: NuAge cohort

Nutritional predictors of depression in a cohort of community-dwelling elderly Canadians: NuAge cohort

Association between serum ferritin concentrations and depressive symptoms in Japanese municipal employees

Interactions between Psychological Stress and Drinking Status in Relation to Diet among Middle-Aged Men and Women: A Large-Scale Cross-Sectional Study in Japan

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