Dietary Flaxseed Meal is More Protective Than Soy Protein Concentrate Against Hypertriglyceridemia and Steatosis of the Liver in an Animal Model of Obesity

Abstract

The marked hypotriglyceridemic and hypocholesterolemic effects of flaxseed meal may have important therapeutic implications in patients with hypertriglyceridemia and hypercholesterolemia and deserve further study in humans with these disorders. Flaxseed meal supplementation may provide a new therapeutic strategy to reduce hypertriglyceridemia and fatty liver.

Efeito da linhaça (Linum usitatissimum L.) sob diferentes formas de preparo na resposta biológica em ratos

“…Bhathena et al 32 avaliaram o consumo de farinha de linhaça e proteína de soja em ratos obesos, constatando maior redução de triglicerídios séricos nos animais alimentados com a linhaça em relação aos que receberam soja. No presente estudo, os valores de triglicerídios dos grupos alimentados com linhaça crua e óleo de linhaça foram menores quando comparados aos grupos LA e P, embora a diferença só tenha sido estatisticamente significante em relação ao grupo P. Portanto, observa-se que em todos os grupos que receberam linhaça houve uma tendência de redução do triglicerídio sérico.…”

“…O colesterol total foi menor em todos os tratamentos com linhaça em relação ao controle. O decréscimo do colesterol plasmá-tico pela administração do óleo de linhaça é relacionado com a diminuição do colesterol livre e do esterificado, e também com a n-6:n-3 32 . O efeito hipocolesterolêmico da linhaça tem importantes implicações terapêuticas em pacientes dislipidêmicos, sendo que estudos em humanos têm mostrado que o consumo de 40 a 50g/dia reduz o colesterol sérico entre 5% e 9% 32,34 .…”

Microangiopathy and visual deficits characterize the retinopathy of a spontaneously hypertensive rat model with type 2 diabetes and metabolic syndrome

“…We therefore set out to address this point in an experimental setting by investigating the retina in the obese and spontaneously hypertensive corpulent (SHR/N-cp) rat model. 12 This model combines obesity, type 2 diabetes, hypertension and hyperlipidemia 13 and exhibits a wide range of target organ damage; atherosclerosis, 12 hepatic steatosis, 14 pancreatic islet cell hyperplasia, 15 cardiomyopathy 16 and nephropathy 17,18 have been described in SHR/ N-cp. Furthermore, this model demonstrates an important feature of the metabolic syndrome, that is, insulin resistance, 19 which has also gained importance with regard to the pathogenesis of retinopathy, particularly retinal neovascularization.…”

Omega 3, 6, 9 Enhanced Goat Meat (Omega-Chevon) from Flaxseed and Canola Fed Meat Goats

“…Much attention has been given to flax consumption as being beneficial for the management of blood pressure, CVD, diabetes, and immune function (Adlercreutz, 2007;Barre, Mizier-Barre, Griscti, & Hafez, 2008;Basch et al, 2007;Bhardwaj, Hamama, Narina, & Parry, 2012;Bhathena et al, 2003;Farran et al, 2008;Fritsche & Cassity, 1992;Hillyer, Sandiford, Gray, & Woodward, 2006;Lessard, Gagnon, & Petit, 2003;Leyva et al, 2011;Mandaşescu et al, 2005;Park, H. J., Park, J. S., Hayek, Reinhart, & Chew, 2011;Saini, Harjai, Mohan, Punia, & Chhibber, 2010;Thies et al, 2001;Wallace, Miles, & Calder, 2003). Past research indicates that products, such as eggs (Antruejo et al, 2011;Raes et al, 2002;Schumann, Squires, Leeson, & Hunter, 2003;Yalç in & Unal, 2010) and beef (Juá rez et al, 2011;Kronberg, Scholljegerdes, Lepper, & Berg, 2011;Nassu et al, 2011;Quinn et al, 2008;Scholljegerdes & Kronberg, 2010), from animals fed flax have increased levels of omega-3 fatty acids.…”

“…particularly in cardiovasucular disease (CVD), obesity and immunity (Adlercreutz, 2007;Bhathena et al, 2003;Nelson, Stevens, & Hickey, 2007). Flax contains about 20% alpha linolenic acid, an essential omega-3 fatty acid, a precursor for Eicosapentaenoic Acid (EPA), which is a precursor for eicosanoids, hormone-like compounds involved in the immune response (Cathcart, Lysaght, & Pidgeon, 2011;Hogenkamp et al, 2011;Kapoor & Huang, 2006).…”