Dietary Flax Oil During Pregnancy and Lactation Retards Disease Progression in Rat Offspring With Inherited Kidney Disease

Abstract

Dietary flax oil (FO) retards disease progression in growing or adult animal models of kidney disease. To determine whether dietary flax oil during the perinatal period would alter renal disease progression in offspring, Han-SPRD-cy rats with inherited cystic kidney disease were given diets with either 7% FO or corn oil (CO), throughout pregnancy and lactation. At 3 wk of age, offspring were then given either the same or the alternate diet for 7 wk. Rats given FO during the maternal period had 15% less renal cyst growth compared with rats given FO only in the postweaning period. Dietary FO, compared with CO, in the maternal period also resulted in 12% lower cell proliferation and 15% less oxidant injury in diseased kidneys of offspring. Including FO in both the maternal and postweaning period resulted in 29 -34% less renal interstitial fibrosis and 22-23% lower glomerular hypertrophy. Along with improved histology, these rats exhibited 13% less proteinuria and 30% lower creatinine clearance when dietary FO was given in the maternal period. The potential for dietary FO during pregnancy and lactation to positively modulate adult renal disease has significant implications for the 1 in 1000 individuals with congenital cystic kidney disease.

Efficacy of flax oil in preventing postoperative peritoneal adhesions

“…Various models have been developed for generating experimental PPA, including abrasion, local excision of the peritoneum, ischemic injury, placement of a foreign body in the peritoneal cavity (e.g., talcum powder), thermal injury, and bacterial contamination [20][21][22][23][24][25][26]. We have utilized an abrasion model, due to its ability to mimic mechanical trauma, which can occur after laparotomy.…”

“…Dietary flax oil retard kidney disease progression when initiated in early and also late stages of disease in several experimental models [23][24][25][26]. Flaxseed meal is effective in preventing colon tumor development when compared with dietary corn meal [27].…”

Trans-10,cis-12-conjugated linoleic acid worsens renal pathology and alters cyclooxygenase derived oxylipins in obesity-associated nephropathy

“…MGV was calculated by measuring the maximum diameter of each glomerular tuft using Image-Pro Plus Software 6.0 measurement tools. The diameters (μm) were converted to MGV using the following equations: mean glomerular area (MGA)=πr 2 and MGV=1.25 (MGA) 3/2 , as developed by Weibel [60] and described previously [61]. To determine glomerular fibrosis, 25 randomly selected glomeruli were examined by light microscopy using a 40× objective to examine one glomerulus per slide.…”

Evaluating the therapeutic value of omega-3 polyunsaturated fatty acid supplementation on polycystic kidney disease and co-morbidities

“…Adult (age 2 months) male Han:SPRD-cy rats in the advanced stage of ADPKD fed 16% kcal ALA-rich flaxseed oil for 4 months showed no significant effect on renal cyst volume and interstitial fibrosis compared to rats fed LNA-rich corn oil. On the other hand, Hans:SPRD-cy rats exposure to ALA by providing rat dams 16% kcal flaxseed through pregnancy and lactation resulted in offspring with less renal cyst growth, proliferation, oxidation, and increased renal function compared to offspring exposed to flaxseed oil starting at weaning [32] ( Table 1). The study results indicated that early diet intervention was beneficial for attenuating PKD development and progression.…”