Dietary fish oil normalize dyslipidemia and glucose intolerance with unchanged insulin levels in rats fed a high sucrose diet

Lombardo, Yolanda B.; Chicco, Adriana; D'Alessandro, María Eugenia; Martinelli, M; Soria, Ana; Gutman, R.

doi:10.1016/0005-2760(95)00197-2

Cited by 42 publications

(62 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Using this experimental model, Lombardo et al [87] showed that hypertriglyceridemia and glucose intolerance ensuing long-term feeding normal rats with a sucrose-rich diet could be completely reversed mediating no changes in circulating insulin levels by shifting the source of fat in the diet from corn oil (18% total energy) to fish oil (cod liver oil, 16% plus corn oil 2% total energy) during 1 or 2 months. Under similar experimental conditions, D'Alessandro et al [88] studied the effect of fish oil on triglyceride metabolism, glucose oxidation and glycogen storage during both the basal state and the euglycemic clamp in skeletal muscle.…”

Section: 122mentioning

confidence: 97%

Effects of dietary polyunsaturated n-3 fatty acids on dyslipidemia and insulin resistance in rodents and humans. A review

Lombardo

Chicco

2006

The Journal of Nutritional Biochemistry

Self Cite

321

234

View full text Add to dashboard Cite

Section: 122mentioning

confidence: 97%

Effects of dietary polyunsaturated n-3 fatty acids on dyslipidemia and insulin resistance in rodents and humans. A review

Lombardo

Chicco

2006

The Journal of Nutritional Biochemistry

Self Cite

321

234

View full text Add to dashboard Cite

“…Pyruvate dehydrogenase complex (PDHc), and glucose-6-P-dehydrogenase (G-6-PDH) activities were analyzed as previously described [21]. The triglyceride secretion rate (VLDL-Tg secretion) was evaluated in 12-h fasting rats following the procedure described by Lombardo et al [20].…”

Section: Liver Tissue Assaysmentioning

confidence: 99%

“…In this vein, it has been shown that FO prevents the onset of insulin resistance and dyslipidemia when fed to rats with high fat [2,[15][16][17] or high sucrose diets [2,18,19]. However, relatively few studies have examined the effectiveness of FO in reversing diet-induced insulin resistance [20][21][22][23]. Therefore, the rats fed a long-term sucrose-rich diet seem to be an appropriate experimental model to investigate the effect of dietary n-3 PUFAs (fish oil) to improve or reverse these metabolic abnormalities.…”

Section: Introductionmentioning

confidence: 95%

Metabolic Syndrome: Effects of n‐3 PUFAs on a Model of Dyslipidemia, Insulin Resistance and Adiposity

Lombardo

Hein

Chicco

2007

Lipids

Self Cite

112

View full text Add to dashboard Cite

Both genetic and environmental factors (e.g. nutrition, life style) contribute to the development of the plurimetabolic syndrome, which has a high prevalence in the world population. Dietary n-3 PUFAs specially those from marine oil (EPA and DHA) appear to play an important role against the adverse effects of this syndrome. The present work examined the effectiveness of fish oil (FO) in reversing or improving the dyslipidemia, insulin resistance and adiposity induced in rats by long-term feeding a sucrose-rich diet (SRD). We studied several metabolic and molecular mechanisms involved in both lipid and glucose metabolisms in different tissues (liver, skeletal muscle, fat pad) as well as insulin secretion patterns from perifused islets under the stimulation of different secretagogues. Dietary FO reverses dyslipidemia and improves insulin action and adiposity in the SRD fed rats. FO reduces adipocytes cell size and thus, the smaller adipocytes are more insulin sensitive and the release of fatty acids decreases. In muscle, FO normalizes both the oxidative and non-oxidative glucose pathways. Moreover, FO modifies the fatty acid composition of membrane phospholipids. In isolated beta cells, lipid contents and glucose oxidation return to normal. All these effects could contribute to the normalization of glucose-stimulated insulin secretion and muscle insulin insensitivity.

show abstract

“…A atividade enzimática da lipase lipoproteica tem demonstrado ser maior para os animais que recebem fontes alimentares ricas em ácidos graxos insaturados, principalmente da série ϖ3 16,22,23 . Entretanto, não foi observada diferença significativa quanto à atividade sérica desta enzima quando comparado o grupo que apresentou a maior concentração de ácido linolênico (grupo S) com os demais grupos.…”

Section: I S C U S S ã Ounclassified

Lipídeos séricos e morfologia hepática de ratos alimentados com diferentes fontes lipídicas (óleo de soja, gordura de peixe e porco, margarina e manteiga)

et al. 2011

View full text Add to dashboard Cite

OBJETIVO: Analisar as alterações lipídicas séricas e morfológicas hepáticas de ratos alimentados com diferentes fontes lipídicas (óleo de soja, gordura de peixe e porco, margarina e manteiga). MÉTODOS: Os 50 ratos Wistars utilizados no estudo foram divididos em cinco grupos, que durante 28 dias receberam dietas semissintéticas com diferentes fontes lipídicas: óleo de soja, gordura de porco, manteiga, margarina e gordura de peixe. Foram avaliados os pesos corporais, o consumo alimentar e o coeficiente de eficiência alimentar; a atividade da lipase lipoproteica; as concentrações séricas de colesterol total e de lipoproteína de alta densidade - colesterol, triacilgliceróis e albumina, bem como a histologia dos tecidos hepático e cardíaco. RESULTADOS: O tipo de fonte lipídica não influenciou o consumo alimentar, o ganho de peso, o coeficiente de eficiência alimentar dos animais, nem a atividade da lipase lipoproteica, porém promoveu alterações nas concentrações séricas de colesterol total, lipoproteína de alta densidade - colesterol, triacilgliceróis e albumina. Todos os grupos apresentaram gotículas lipídicas nas paredes coronarianas e nos capilares cardíacos, sendo caracterizada como esteatose a deposição de gordura no fígado dos animais que receberam óleo de soja, gordura de peixe, de porco e manteiga. CONCLUSÃO: A fonte lipídica que apresentou os melhores resultados foi o óleo de soja, enquanto o consumo de gordura do peixe causou efeito sérico e tecidual semelhante ao encontrado para as outras fontes lipídicas (gordura de porco, manteiga e margarina), as quais podem contribuir para o surgimento e a progressão das doenças cardiovasculares.

show abstract

Dietary fish oil normalize dyslipidemia and glucose intolerance with unchanged insulin levels in rats fed a high sucrose diet

Cited by 42 publications

References 27 publications

Effects of dietary polyunsaturated n-3 fatty acids on dyslipidemia and insulin resistance in rodents and humans. A review

Effects of dietary polyunsaturated n-3 fatty acids on dyslipidemia and insulin resistance in rodents and humans. A review

Metabolic Syndrome: Effects of n‐3 PUFAs on a Model of Dyslipidemia, Insulin Resistance and Adiposity

Lipídeos séricos e morfologia hepática de ratos alimentados com diferentes fontes lipídicas (óleo de soja, gordura de peixe e porco, margarina e manteiga)

Contact Info

Product

Resources

About