Dietary fiber intake and head and neck cancer risk: A pooled analysis in the International Head and Neck Cancer Epidemiology consortium

Kawakita, Daisuke; Lee, Yuan Chin Amy; Turati, Federica; Parpinel, Maria; Decarli, Adriano; Serraino, Diego; Matsuo, Keitaro; Olshan, Andrew F.; Zevallos, José P.; Winn, Deborah M.; Moysich, Kirsten B.; Zhang, Zuo‐Feng; Morgenstern, Hal; Levi, Fabio; Kelsey, Karl T.; McClean, Michael D.; Bosetti, Cristina; Garavello, Werner; Schantz, Stimson P.; Gao, Yu; Boffetta, Paolo; Chuang, Shu Chun; Hashibe, Mia; Ferraroni, Monica; Vecchia, Carlo La; Edefonti, Valeria

doi:10.1002/ijc.30886

Cited by 30 publications

(27 citation statements)

References 58 publications

(155 reference statements)

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“…Head and neck squamous cell carcinoma (HNSCC) is the seventh most common cancer type worldwide, with >500,000 new cases of HNSCC diagnosed worldwide every year. Approximately 60% of HNSCC are diagnosed at an advanced stage, and the prognosis is poor, despite the numerous forms of treatment available (1,2). In recent decades, the 5-year survival rate has improved (3).…”

Section: Introductionmentioning

confidence: 99%

PD‑L1 promotes head and neck squamous cell carcinoma cell growth through mTOR signaling

Zheng

Chen

et al. 2019

Oncol Rep

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Programmed death-ligand 1 (PD-L1), an immune co-stimulatory molecule, is expressed on various cancer cells and the surface of immune cells. Its overexpression on tumor cells suppresses the immune response to promote tumor cell immune escape. The present study demonstrated that PD-L1 was critical in head and neck squamous cell carcinoma (HNSCC) carcinogenesis. Immunohistochemical analysis of HNSCC tissue microarrays revealed that PD-L1 was overexpressed in tumor tissue, and its expression increased as tumor malignancy progressed (from grade I to IV). Subsequently, the expression of PD-L1 was knocked down or overexpressed in the HNSCC cell lines Cal-27 and Fadu. It was demonstrated that PD-L1 significantly induced HNSCC cell proliferation and colony forming ability. Cell proliferation was also promoted in Cal-27 cell xenograft BALB/c nude mice. In addition, it was determined by western blotting that the PD-L1-mediated increase in HNSCC cell proliferation may have been associated with the activation of mammalian target of rapamycin (mTOR) signaling pathway. Furthermore, mTOR inhibitor (rapamycin) prevented the increase in proliferation. Based on these results, it was concluded that PD-L1 promoted cell proliferation of HNSCC cells through mTOR signaling, and blocking PD-L1 may be conducive in HNSCC therapy.

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Section: Introductionmentioning

confidence: 99%

PD‑L1 promotes head and neck squamous cell carcinoma cell growth through mTOR signaling

Zheng

Chen

et al. 2019

Oncol Rep

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“…However, the prevalence of alcohol consumption among U.S. adults has not decreased substantially in recent years ( 60 ). Decreased dietary fiber intake also might be associated with risk for laryngeal cancer, particularly among women ( 61 – 63 ).…”

Section: Discussionmentioning

confidence: 99%

Surveillance for Cancers Associated with Tobacco Use — United States, 2010–2014

Gallaway

Henley

Steele

et al. 2018

MMWR Surveill. Summ.

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Problem/ConditionTobacco use is the leading preventable cause of cancer, contributing to at least 12 types of cancer, including acute myeloid leukemia (AML) and cancers of the oral cavity and pharynx; esophagus; stomach; colon and rectum; liver; pancreas; larynx; lung, bronchus, and trachea; kidney and renal pelvis; urinary bladder; and cervix. This report provides a comprehensive assessment of recent tobacco-associated cancer incidence for each cancer type by sex, age, race/ethnicity, metropolitan county classification, tumor characteristics, U.S. census region, and state. These data are important for initiation, monitoring, and evaluation of tobacco prevention and control measures.Period Covered2010–2014.Description of SystemCancer incidence data from CDC’s National Program of Cancer Registries and the National Cancer Institute’s Surveillance, Epidemiology, and End Results program were used to calculate average annual age-adjusted incidence rates for 2010–2014 and trends in annual age-adjusted incidence rates for 2010–2014. These cancer incidence data cover approximately 99% of the U.S. population. This report provides age-adjusted cancer incidence rates for each of the 12 cancer types known to be causally associated with tobacco use, including liver and colorectal cancer, which were deemed to be causally associated with tobacco use by the U.S. Surgeon General in 2014. Findings are reported by demographic and geographic characteristics, percentage distributions for tumor characteristics, and trends in cancer incidence by sex.ResultsDuring 2010–2014, approximately 3.3 million new tobacco-associated cancer cases were reported in the United States, approximately 667,000 per year. Age-adjusted incidence rates ranged from 4.2 AML cases per 100,000 persons to 61.3 lung cancer cases per 100,000 persons. By cancer type, incidence rates were higher among men than women (excluding cervical cancer), higher among non-Hispanics than Hispanics (for all cancers except stomach, liver, kidney, and cervical), higher among persons in nonmetropolitan counties than those in metropolitan counties (for all cancers except stomach, liver, pancreatic, and AML), and lower in the West than in other U.S. census regions (all except stomach, liver, bladder, and AML). Compared with other racial/ethnic groups, certain cancer rates were highest among whites (oral cavity and pharyngeal, esophageal, bladder, and AML), blacks (colon and rectal, pancreatic, laryngeal, lung and bronchial, cervical, and kidney), and Asians/Pacific Islanders (stomach and liver). During 2010–2014, the rate of all tobacco-associated cancers combined decreased 1.2% per year, influenced largely by decreases in cancers of the larynx (3.0%), lung (2.2%), colon and rectum (2.1%), and bladder (1.3%).InterpretationAlthough tobacco-associated cancer incidence decreased overall during 2010–2014, the incidence remains high in several states and subgroups, including among men, whites, blacks, non-Hispanics, and persons in nonmetropolitan counties. These disproportionately high rat...

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“…The researchers acknowledged the inconsistency and called for further investigation. Kawakita et al reported an inverse relationship between fiber intake and oropharyngeal and laryngeal cancers in ten pooled case-control INHANCE studies [74]. Despite the results, considerable heterogeneity among study designs was a limitation.…”

Section: Primary Prevention Of Cancer: Dietary Fiber and Other Complementioning

confidence: 99%

Carbohydrate Nutrition and the Risk of Cancer

et al. 2019

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Purpose of Review This review summarizes a selection of epidemiologic research assessing the associations between carbohydrate intake and cancer incidence and survival. Evidence for plausible biological mechanisms is also considered. Recent Findings The mechanistic paradigm explaining the relationship between carbohydrates and cancer risk has been contested by numerous observational studies. Summary Carbohydrates have conventionally been ascribed a deleterious role in the field of cancer research due to previous preclinical findings. A breadth of studies suggests that complex carbohydrate intake is inversely associated with risk of a number of cancer types. Data from studies assessing simple carbohydrates and cancer risk are mixed. Furthermore, recommendations for subsequent studies are framed.

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Dietary fiber intake and head and neck cancer risk: A pooled analysis in the International Head and Neck Cancer Epidemiology consortium

Cited by 30 publications

References 58 publications

PD‑L1 promotes head and neck squamous cell carcinoma cell growth through mTOR signaling

PD‑L1 promotes head and neck squamous cell carcinoma cell growth through mTOR signaling

Surveillance for Cancers Associated with Tobacco Use — United States, 2010–2014

Carbohydrate Nutrition and the Risk of Cancer

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