Dietary fats promote inflammation in Wistar rats as well as induce proliferation, invasion of SKOV3 ovarian cancer cells

Saeidi, Jafar; Motaghipur, Reza; Sepehrian, Atefe; Mohtashami, Mahnaz; Nia, Fatemeh Forooghi; Gharehbaghian, Ahmad

doi:10.1111/jfbc.13177

Cited by 5 publications

(5 citation statements)

References 70 publications

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“…A diet high in oil, fat, and salt is also undesirable. A study on animals subjected to a high-fat diet reported the diet may promote the development of ovarian cancer by disrupting the levels of inflammatory factors ( 39 ). Therefore, poor diet and health habits are crucial risk factors for the occurrence of cancer.…”

Section: Gynecologic Malignancies and Gmmentioning

confidence: 99%

Gut Microbes in Gynecologic Cancers: Causes or Biomarkers and Therapeutic Potential

et al. 2022

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The human intestine is home to a variety of microorganisms. In healthy populations, the intestinal flora shares a degree of similarity and stability, and they have a role in the metabolism, immunological response, and physiological function of key organs. With the rapid advent of high-throughput sequencing in recent years, several researchers have found that dysbiosis of the human gut microflora potentially cause physical problems and gynecological malignancies among postmenopausal women. Besides, dysbiosis hinders tumor treatment. Nonetheless, the importance of maintaining homeostatic gut microbiota and the effective use of probiotics in the treatment of gynecological malignancies should not be disregarded. Moreover, intestinal flora regulation and the involvement of probiotics as well as associated biologically active substances in gynecological malignancies could be an adjuvant treatment modality related to surgery and chemoradiotherapy in the future. Herein, this article aims to review the potential relationship between gut microorganisms and postmenopausal status as well as gynecologic malignancies; then the relationship between gut microbes and early screening as well as therapeutic aspects. Also, we describe the role of probiotics in the prevention, treatment, and prognosis of gynecologic malignancies.

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Section: Gynecologic Malignancies and Gmmentioning

confidence: 99%

Gut Microbes in Gynecologic Cancers: Causes or Biomarkers and Therapeutic Potential

et al. 2022

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“…Several potential mechanisms underlie this relationship, including metabolic alterations, immune microenvironment modulation, and chronic low‐grade inflammation due to obesity. Diet also contributes to inflammation as a high‐fat diet has been shown to enhance ovarian cancer progression and upregulate inflammatory markers IL‐6, IL‐1β, and TNFα 135 . Estrogen‐mediated signaling via ERα also links obesity to ovarian cancer as ovaries are both the primary producers and targets of estrone (E1) and estradiol (E2).…”

Section: Methodsmentioning

confidence: 99%

“…Diet also contributes to inflammation as a high‐fat diet has been shown to enhance ovarian cancer progression and upregulate inflammatory markers IL‐6, IL‐1β, and TNFα. 135 Estrogen‐mediated signaling via ERα also links obesity to ovarian cancer as ovaries are both the primary producers and targets of estrone (E1) and estradiol (E2). ERα activation enhances downstream upregulation of proteins involved in cell proliferation, motility, and invasion.…”

Section: Methodsmentioning

confidence: 99%

The impact of obesity and adipokines on breast and gynecologic malignancies

Tewari

Vargas

Reizes

2022

Annals of the New York Academy of Sciences

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The link between obesity and multiple disease comorbidities is well established. In 2003, Calle and colleagues presented the relationship between obesity and several cancer types, including breast, ovarian, and endometrial malignancies. Nearly, 20% of cancer‐related deaths in females can be accounted for by obesity. Identifying obesity as a risk factor for cancer led to a focus on the role of fat‐secreted cytokines, known as adipokines, on carcinogenesis and tumor progression. Early studies indicated that the adipokine leptin increases cell proliferation, invasion, and inhibition of apoptosis in multiple cancer types. As a greater appreciation of the obesity–cancer link has amassed, we now know that additional adipokines can impact tumorigenesis. A deeper understanding of the adipokine‐activated signaling in cancer may identify new treatment strategies irrespective of obesity. Moreover, adipokines may serve as disease biomarkers, harnessing the potential of obesity‐associated factors to serve as indicators of treatment response and disease prognosis. As studies investigating obesity and women's cancers continue to expand, it has become evident that breast, ovarian, and uterine cancers are distinctly impacted by adipokines. While complex, these distinct interactions may provide insight into cancer progression in these organs and new opportunities for targeted therapies. This review aims to organize and present the literature from the last 5 years investigating the mechanisms and implications of adipokine signaling in breast, endometrial, and ovarian cancers with a special focus on leptin and adiponectin.

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“…Uncoated and Ch-AgNPs were evaluated for their antiproliferative activity on HT29 colorectal cancer cell line by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) (MTT) assay (Saeidi et al, 2020). Cells were seeded at a density of 1x10 4 cells/well in 96-well plates and were cultured in DMEM medium supplemented with 10% FBS and 1% pen-strept solution at 37°C in 5% CO2.…”

Section: Determining Antiproliferative Activity Of Nps and Ch-agnpsmentioning

confidence: 99%

Green Synthesis of Chitosan-Coated Silver Nanoparticles (Ch-AgNPs): Harnessing Nature for Sustainable and Safe Nanomaterial Production

Kara,

Özçelik

2024

Osmaniye Korkut Ata Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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The production of silver nanoparticles (AgNPs) using green synthesis methods promotes the use of environmentally friendly materials and facilitates a more sustainable production process by reducing environmental impact. In addition, combining the metal nanoparticles with biopolymers are getting important to enhance the safety profiles of formulations to determine the biological activities. With this concept, AgNPs were synthesized by green synthesis method from Betula spp. tree branches as reported previously by us and in current study, synthesized AgNPs were coated by one of biopolymer. Herein, Chitosan was used as capping and stabilizing agent. Characterization of the biosynthesized silver nanoparticles (AgNPs) and Chitosan coated silver nanoparticles (Ch-AgNPs) were evaluated with various techniques. Through this analysis, it was elucidated that the phenolic compounds present in Betula extract and Chitosan played dual roles as both reducing and capping agents, facilitating the formation of Ch-AgNPs. Particular size analysis by dynamic light scattering (DLS) and scanning electron microscopy (SEM) indicated that the Ch-AgNPs ranged from 49 to 118 nm in size, with a narrow size distribution. X-Ray Differentiation (XRD) patterns confirmed the high crystallinity of the resulting particles. Fourier transform infrared (FTIR) analysis further supported these findings, revealing the involvement of phenolic compound extracts in both the formation and stabilization of AgNPs. Additionally, FTIR confirmed the surface modification of AgNPs by chitosan. The efficiency of surface modified Ch-AgNPs was compared with uncoated AgNPs for their antimicrobial activity, antiproliferative efficiency and biocompatibility. Cell culture studies demonstrated that AgNPs were less toxic to L929 cells while maintaining effective cytotoxicity against HT-29 cells. Moreover, surface modification with chitosan enhanced the toxicity of AgNPs against HT-29 cells Furthermore, the first synthesized and evaluated Ch-AgNPs with this study from Betula extract, exhibited potent antimicrobial activity against both Gram-positive and Gram-negative bacteria. Our findings indicate that novel synthesized Ch-AgNPs formula may present a biocompatible and safety approach for further anticancer and antimicrobial studies.

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Dietary fats promote inflammation in Wistar rats as well as induce proliferation, invasion of SKOV3 ovarian cancer cells

Cited by 5 publications

References 70 publications

Gut Microbes in Gynecologic Cancers: Causes or Biomarkers and Therapeutic Potential

Gut Microbes in Gynecologic Cancers: Causes or Biomarkers and Therapeutic Potential

The impact of obesity and adipokines on breast and gynecologic malignancies

Green Synthesis of Chitosan-Coated Silver Nanoparticles (Ch-AgNPs): Harnessing Nature for Sustainable and Safe Nanomaterial Production

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