Dietary fats and coronary heart disease pathogenesis

Renaud, S.; Lanzmann‐Petithory, Dominique

doi:10.1007/s11883-002-0045-z

Cited by 25 publications

(10 citation statements)

References 48 publications

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“…According to our results, ALA treatment prolonged both indices in mice, consistent with the results from previously report [23]. Furthermore, ALA isolated from the seeds can greatly enhance the survival rate of mice suffering from collagen/adrenaline-induced thrombosis and decrease the mass of thrombus formed during A-V bypass.…”

Section: Discussionsupporting

confidence: 93%

Anti-thrombotic effects of α-linolenic acid isolated from Zanthoxylum bungeanum Maxim seeds

Yang

Cao

Zhou

et al. 2014

BMC Complement Altern Med

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BackgroundThe current study was to evaluate the anti-thrombotic effect of alpha-linolenic acid (ALA) which was isolated and purified from Jiaomu in vivo.MethodsThe seeds were crushed and subsequently subjected to saponification, acid hydrolysis, gradient freezing, urea inclusion and complexation of silver nitrate to obtain the unsaturated fatty acids. The chemical characteristics of isolated ALA were validated by 1HNMR, 13CNMR and mass spectrometry, and then the anti-thrombotic effect of ALA and its mixture with linoleic acid (1:1) were evaluated in the following experiments.ResultsThe alpha-linolenic acid was isolated and purified from Jiaomu through our newly established methods. ALA and its mixture with linoleic acid can prolong the hemorrhage and coagulation time as well as enhanced the survival rate of mice subjected to collagen-adrenaline induced thrombosis. In addition, the thrombosis on A-V bypass and platelet aggregation of rats will be reduced after treated with ALA or its mixture, and the expression level of Akt and PI3K protein decreased 26% and 31%, respectively.ConclusionsWe designed and optimized a very simple and high-yield procedure to isolate ALA and linoleic acid mixture from seeds of Zanthoxylum bungeanum Maxim and demonstrated that such mixture can obtain a good anti-thrombotic effect through the modulation of PI3K/Akt signaling.

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Section: Discussionsupporting

confidence: 93%

Anti-thrombotic effects of α-linolenic acid isolated from Zanthoxylum bungeanum Maxim seeds

Yang

Cao

Zhou

et al. 2014

BMC Complement Altern Med

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“…Saturated fatty acids raise total-and low density lipoproteincholesterol (LDL-C) (Renaud and Lanzmann-Petithory, 2002;Hu et al, 2001;Ascherio, 2002;Lichtenstein et al, 1998), although the potency of individual fatty acid varies. Myristic acid (C14:0), palmitic acid (C16:0), and lauric acid (C12:0) are thought to be responsible for the hypercholesterolaemic effect of SFA, with stearic acid (C18:0) considered to be relatively neutral.…”

Section: Impact On Blood Cholesterolmentioning

confidence: 99%

Impact of Oil used by the Frying Industry on Population Fat Intake

Minihane

Harland

2007

Critical Reviews in Food Science and Nutrition

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Chronic multifactorial diet related diseases are the major causes of death and illness worldwide. The amount and composition of fat in the diet is an important determinant of the pathobiology of many of these conditions. In the current review the associations between dietary fat and disease risk will be considered. Mean population fat intakes will be compared with dietary recommendations aimed at reducing the population burden of disease and the main sources of fat in the adult and childhood diet will be given. An assessment will be made of the principal vegetable oil sources used in the manufacture of processed foods, in particular fried foods, with particular reference to the rheological and nutritional justification for their use. The impact of the more widespread use of alternative oil sources with improved fatty acid profiles, on the fat composition of fried foods and the overall diet will be presented, demonstrating that such apparently focussed approaches could potentially result in a significant impact on population fat intake and potentially overall chronic disease burden.

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“…Diet can modulate the haemostatic equilibrium. Diets rich in fish, (especially blue fish) has an antiaggregant effect, mainly due to its content of n-3 fatty acids, which interferes with platelets metabolism (Renaud & Lanzmann-Petithory, 2002;Seo et al, 2005). Furthermore, the direct effect of n-3 fatty acids reducing cardiovascular events and cardiovascular mortality has been proved both in epidemiological studies and clinical trials, although some recent studies failed to find such advantages (Filion et al, 2010;Harris et al, 2008;Lavie et al, 2009;Mente et al, 2009;Riediger et al, 2009).…”

Section: Mediterranean Diet and Hemostasismentioning

confidence: 99%