Dietary Factors in Relation to Liver Fat Content: A Cross-sectional Study

Watzinger, Cora; Nonnenmacher, Tobias; Grafetstätter, Mirja; Sowah, Solomon A; Ulrich, Cornelia M.; Kauczor, H.-U.; Kaaks, Rudolf; Schübel, Ruth; Nattenmüller, Johanna; Kühn, Tilman

doi:10.3390/nu12030825

Cited by 27 publications

(16 citation statements)

References 33 publications

(55 reference statements)

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“…The nested case-controls analysis carried out within the multiethnic cohort that involved 2959 NAFLD cases (509 with cirrhosis and 2450 without cirrhosis) and 29,292 matched controls showed that higher DASH scores were inversely associated with NAFLD risk [ 64 ]. In agreement, the DASH score was related to lower liver fat content and NAFLD in a recent cross-sectional study [ 65 ].…”

Section: Nutritional Management Of Nafldsupporting

confidence: 67%

Nutritional Approaches for the Management of Nonalcoholic Fatty Liver Disease: An Evidence-Based Review

2020

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Nonalcoholic fatty liver disease (NAFLD) is on the rise worldwide representing a public health issue. Its coexistence with obesity and other metabolic alterations is highly frequent. Therefore, current therapy interventions for NAFLD are mainly focused on progressive weight loss through modulation of overall calorie intake with or without specific macronutrient adjustments. Furthermore, other relevant nutritional interventions are built on food selection and time-restricted eating. Since every strategy might bring different results, choosing the optimal diet therapy for a patient is a complicated task, because NAFLD is a multifactorial complex disease. Importantly, some factors need to be considered, such as nutrition-based evidence in terms of hepatic morphophysiological improvements as well as adherence of the patient to the meal plan and adaptability in their cultural context. Thus, the purpose of this review is to explore and compare the subtleties and nuances of the most relevant clinical practice guidelines and the nutritional approaches for the management of NAFLD with a special attention to tangible outcomes and long-term adherence.

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Section: Nutritional Management Of Nafldsupporting

confidence: 67%

Nutritional Approaches for the Management of Nonalcoholic Fatty Liver Disease: An Evidence-Based Review

2020

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“…A recently published study by Watzinger et al evaluated the dietary factors that affect the liver fat content. They observed that a higher intake of high-fat dairy, such as sour cream in our study, is associated with non-alcoholic fatty liver disease, thus increasing the liver function tests, results that were in accordance with ours [ 20 ].…”

Section: Discussionsupporting

confidence: 92%

Eating Habits in Patients with Familial Hypercholesterolemia from North-Eastern Romania

et al. 2022

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(1) Background: Familial hypercholesterolemia (FH) is a genetic autosomal dominant disorder characterized by elevated levels of low-density lipoprotein cholesterol (LDL) that develops deposits of lipids in the arterial wall. Since it is underdiagnosed and undertreated, the disease has a high risk of premature cardiovascular disease and death. Patients are not always aware of the changes they should make in their diet. Thus, our study aimed to evaluate through a food frequency questionnaire their eating habits. (2) Methods: We included 70 patients with FH and 20 subjects in a control group that were evaluated through a physical examination and blood tests. They also completed a food frequency questionnaire. (3) Results: Throughout our study, we observed several aspects: regardless of age, patients with FH had higher carbohydrate intakes compared to the control group; from the same group, a positive correlation was observed between salami intake and the levels of glucose and glycated hemoglobin. Moreover, the sour cream preference was associated with higher liver function tests. In the control group, we observed a higher intake of pasta and fast food and fewer fruit portions. (4) Conclusions: As far as we know, this is the first study from Romania that evaluated the eating habits of patients diagnosed with FH. Our study reveals that, although patients with FH avoid junk food, they still have a high intake of carbohydrates when compared to the control group. Further research is needed in order to get a comprehensive nutritional evaluation of these patients.

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“…Furthermore, a systematic review and meta-analysis reported that DASH might be a better choice for weight management and reduction than other low-energy diets [ 159 ]. Some observational studies suggest that this diet could play a preventive role in NAFLD [ 160 , 161 ].…”

Section: Nutrition and Nafldmentioning

confidence: 99%

Overview of Non-Alcoholic Fatty Liver Disease (NAFLD) and the Role of Sugary Food Consumption and Other Dietary Components in Its Development

2021

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NAFLD is the world’s most common chronic liver disease, and its increasing prevalence parallels the global rise in diabetes and obesity. It is characterised by fat accumulation in the liver evolving to non-alcoholic steatohepatitis (NASH), an inflammatory subtype that can lead to liver fibrosis and cirrhosis. Currently, there is no effective pharmacotherapeutic treatment for NAFLD. Treatment is therefore based on lifestyle modifications including changes to diet and exercise, although it is unclear what the most effective form of intervention is. The aim of this review, then, is to discuss the role of specific nutrients and the effects of different dietary interventions on NAFLD. It is well established that an unhealthy diet rich in calories, sugars, and saturated fats and low in polyunsaturated fatty acids, fibre, and micronutrients plays a critical role in the development and progression of this disease. However, few clinical trials have evaluated the effects of nutrition interventions on NAFLD. We, therefore, summarise what is currently known about the effects of macronutrients, foods, and dietary patterns on NAFLD prevention and treatment. Most current guidelines recommend low-calorie, plant-based diets, such as the Mediterranean diet, as the most effective dietary pattern to treat NAFLD. More clinical trials are required, however, to identify the best evidence-based dietary treatment approach.

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Dietary Factors in Relation to Liver Fat Content: A Cross-sectional Study

Cited by 27 publications

References 33 publications

Nutritional Approaches for the Management of Nonalcoholic Fatty Liver Disease: An Evidence-Based Review

Nutritional Approaches for the Management of Nonalcoholic Fatty Liver Disease: An Evidence-Based Review

Eating Habits in Patients with Familial Hypercholesterolemia from North-Eastern Romania

Overview of Non-Alcoholic Fatty Liver Disease (NAFLD) and the Role of Sugary Food Consumption and Other Dietary Components in Its Development

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