Dietary Diacyiglycerol-Rich Oil Stimulation of Glucose Intolerance in Genetically Obese Rats

Sugimoto, Takumi; Fukuda, Hiroo; Kimura, Tomoe; Iritani, Nobuko

doi:10.3177/jnsv.49.139

Cited by 11 publications

(5 citation statements)

References 28 publications

(21 reference statements)

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“…Sugimoto et al reported the possibility that the replacement of ordinary oil in the diet with DAG oil induced an impaired glucose tolerance in normal rats and Wistar fatty rats that were fed a high-sucrose diet for 12 and 5 wk, respectively (50,51). The findings herein were not consistent with the results reported by Sugimoto et al, and the reason for the discrepancy is not clear.…”

Section: Discussioncontrasting

confidence: 91%

Effect of diacylglycerol on the development of impaired glucose tolerance in sucrose‐fed rats

Meguro

Osaki

Matsuo

et al. 2006

Lipids

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The effects of DAG oil and TAG oil on impaired glucose tolerance in rats that were fed a diet containing high levels of sucrose were compared. Male Wistar rats (8 wk old and 32 wk old) were fed either high-sucrose (57.5% sucrose w/w) or control diets containing either 10% (w/w) DAG or TAG oil with a similar FA composition for 48 wk in 8-wk-old rats and for 24 wk in 32-wk-old rats. Plasma lipids, the size of the islets of Langerhans, and insulin, glucose, and adipocytokine levels were measured. An oral glucose tolerance test (OGTT) was carried out during the study period. For rats in both age groups that were fed a high-sucrose diet, the DAG oil group had lower plasma glucose and insulin response in an OGTT, and lower homeostasis model assessment-R levels, than the TAG oil group. Furthermore, in 8-wk-old rats that were fed a high-sucrose diet, the DAG oil group accumulated less visceral fat and showed suppressed decreases [corrected] of plasma adiponectin and [corrected] increases of plasma insulin, leptin, and the size of islet of Langerhans compared with the TAG oil group. No difference in the OGTT was found between the DAG and TAG oil groups in either age group of rats fed a control diet. In conclusion, these results suggest that DAG oil ingestion prevents the high-sucrose-diet-induced development of impaired glucose tolerance compared with TAG oil ingestion.

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Section: Discussioncontrasting

confidence: 91%

Effect of diacylglycerol on the development of impaired glucose tolerance in sucrose‐fed rats

Meguro

Osaki

Matsuo

et al. 2006

Lipids

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“…The results are summarized in Table 4. A decrease in serum TG has been observed in some studies (24, 25, 26), whereas in others, TG concentrations remained unchanged (12, 17, 27). Many studies in rats have tested the effects of DAG on blood lipid concentrations and investigated the mechanisms by which DAG may affect lipemia.…”

Section: Dag Actions On Blood Lipidsmentioning

confidence: 95%

“…In that study, body weight gain, epididymal white adipose tissue, perirenal white adipose tissue, and interscapular brown adipose tissue weight were found to be lower by 43%, 52%, 85%, and 81%, respectively, than in the animals fed the high TAG oil diet (9). Conversely, it was shown that body weight and abdominal fat weight did not differ in rats consuming either 10% DAG (53.8% 1, 3‐DAG) or TAG (12, 17). Beneficial effects on body weight were observed with a 30% and 15% DAG oil diet, but not with a 10% DAG oil diet.…”

Section: Dag and Body Compositionmentioning

confidence: 96%

“…In rats fed 1.7% or 5.7% DAG for 30 or 77 weeks, no beneficial impact was observed on blood lipid concentrations (27). Supplementation with 10% DAG (53.8% 1, 3‐DAG) for 5 to 12 weeks also failed to decrease plasma TG concentrations in lean and obese rats (12, 17). Another study did not show any beneficial effect of DAG on plasma TG at a dose of 30% (28).…”

Section: Dag Actions On Blood Lipidsmentioning

confidence: 97%

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Diacylglycerol: Efficacy and Mechanism of Action of an Anti‐Obesity Agent

et al. 2005

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Obesity is at the forefront of global health issues and directly contributes to many chronic illnesses. Several dietary components show promise in the treatment of obesity, one of which is oil rich in diacylglycerols (DAGs). Present objectives are to examine scientific knowledge concerning DAG to assess evidence supporting the effects on substrate oxidation rates, body weight and fat mass, and blood lipids, and to assess safety, as well as elucidate potential mechanisms of action. DAG can be synthesized by an enzymatic process to produce mainly 1,3-isoform DAG. This 1,3-DAG oil is believed to have the ability to increase beta-oxidation, to enhance body weight loss, to suppress body fat accumulation, and to lower serum triacylglycerol levels postprandially. While certain animal and human studies indicate that consumption of 1,3-DAG has positive physiological effects, others report no effect. The mechanisms of action of DAG are suggested to decrease the resynthesis of chylomicrons as well as shunting them directly to the liver through the portal vein, where they are oxidized. This increased fat oxidation may influence control of food intake by increasing satiety. Further study into the precise mechanism is required to understand its effects. Safety studies show no risks in consuming a diet rich in DAG oil. Overall, consumption of oils with higher amounts of DAG, specifically 1,3-DAG, may be useful in the battle against obesity.

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“…Several human studies have shown that DAG, compared with the corresponding TAG, suppresses postprandial hypertriacylglycerolemia (1,2) and reduces body fat mass as a long-term effect (3,4). Antiobese effects of DAG oil have been demonstrated in obese model mice (5,6) and rats (7,8) although there are some arguments on its efficacy in Wistar rats (9,10). Murase et al (5) proposed that the feeding of DAG caused an increase in β-oxidation in the liver of rats.…”

mentioning

confidence: 96%

Comparison of the lymphatic transport of radiolabeled 1,3‐dioleoylglycerol and trioleoylglycerol in rats

Yanagita

Ikeda

Wang

et al. 2004

Lipids

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It has been reported that, compared with TAG, DAG suppresses postprandial hypertriacylglycerolemia and reduces visceral fat levels in experimental animals and humans. To clarify the mechanism responsible for these beneficial effects, we compared the lymphatic transport of 1,3-DAG, a major isomer of DAG, and TAG in rats. Male SD rats, after insertion of a cannula into the thoracic duct, were given 1,3-di[1-14C]oleoylglycerol or tri[1-14C]oleoylglycerol via a stomach tube. The 24-h recovery of the radioactivity from 1,3-di[14C]oleoylglycerol in the lymph was slightly but significantly lower than that from tri[14C]oleoylglycerol (81.3+/-1.0 vs. 86.5+/-1.2%, respectively). However, in the first 1-h interval after administration, the recovery of radioactivity from 1,3-dioleoylglycerol was almost half of that from trioleoylglycerol (17.5+/-2.0 vs. 31.1+/-1.4%). The amount of TAG and phospholipids secreted into the lymph was significantly lower 1 h after the administration of 1,3-dioleoylglycerol compared with that after the administration of trioleoylglycerol. More than 90% of the radioactivity recovered in the lymph in the first 3 h was distributed in the TAG fraction for both 1,3-dioleoylglycerol and trioleoylglycerol. These results suggest that slower lymphatic transport of 1,3-DAG compared with TAG could be a factor in the suppression of postprandial hypertriacylglycerolemia. The possibility that the slower lymphatic transport of DAG contributes to the anti-obesity action observed in the feeding of 1,3-DAG cannot be excluded.

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Dietary Diacyiglycerol-Rich Oil Stimulation of Glucose Intolerance in Genetically Obese Rats

Cited by 11 publications

References 28 publications

Effect of diacylglycerol on the development of impaired glucose tolerance in sucrose‐fed rats

Effect of diacylglycerol on the development of impaired glucose tolerance in sucrose‐fed rats

Diacylglycerol: Efficacy and Mechanism of Action of an Anti‐Obesity Agent

Comparison of the lymphatic transport of radiolabeled 1,3‐dioleoylglycerol and trioleoylglycerol in rats

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