Effect of diacylglycerol on the development of impaired glucose tolerance in sucrose‐fed rats

Meguro, Shu; Osaki, Noriko; Matsuo, Noboru; Tokimitsu, Ichiro

doi:10.1007/s11745-006-5105-7

Cited by 12 publications

(10 citation statements)

References 55 publications

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“…Thus, although glucose intolerance and IR developed in the BATless mice between 5 and 10 weeks of the TAG-WTD, this diet effect was absent in the BATless mice consuming DAG-WTD for the same period. Our data are consistent with those in previous studies with Otsuka Long-Evans Tokushima Fatty rats [14] and sucrose-fed Wistar rat [15]. The absence of WTD-induced IR in BATless mice consuming the DAG-WTD was associated with a reduction in hepatic expression of PEPCK.…”

Section: Discussionsupporting

confidence: 93%

“…Some of the most striking effects of DAG oil diets in humans have been on postprandial lipid metabolism [10,11]. Similar benefits of a DAG-enriched diet have been observed in rodents [14,15]. By contrast, in the present study, we did not observe differences in either fasting levels of TG or FA or in postprandial responses during the TAG-FTTs between the DAG-WTD and TAG-WTD groups of BATless mice.…”

Section: Discussionsupporting

confidence: 63%

“…It has also been reported that DAG ameliorates glucose intolerance or prevents the development of impaired glucose tolerance in Otsuka Long-Evans Tokushima Fatty rats [14] and sucrose-fed Wistar rat [15], respectively. These studies suggest that the ingestion of DAG oil not only prevents the accumulation of body fat but also suppresses the development of abnormal carbohydrate metabolism.…”

Section: Introductionmentioning

confidence: 92%

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Dietary 1,3-diacylglycerol protects against diet-induced obesity and insulin resistance

2007

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 63%

Section: Introductionmentioning

confidence: 92%

See 1 more Smart Citation

Dietary 1,3-diacylglycerol protects against diet-induced obesity and insulin resistance

2007

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“…Meguro et al evaluated the DAG effect on insulin response in rats using a high-fat (DAG or TAG oil) and high-sucrose-containing diet. They found that DAG oil decreased plasma postprandial insulin concentrations compared to TAG oil [32]. Several researchers also reported that DAG possesses a suppressive effect on postprandial insulin, possibly resulting in increased insulin sensitivity [12, 33].…”

Section: Discussionmentioning

confidence: 99%

Metabolic and Hormonal Alterations with Diacylglycerol and Low Glycemic Index Starch during Canine Weight Loss

Mitsuhashi

Nagaoka

Bigley

et al. 2012

ISRN Veterinary Science

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Obesity increases insulin resistance and disregulation of glucose homeostasis. This study investigated low glycemic index starch (LGIS)/diacylglycerol (DAG) diet on plasma insulin and circulating incretin hormones during canine weight loss. Obese Beagle dogs were fed one of four starch/oil combination diets (LGIS/DAG; LGIS/triacylglycerol (TAG); high glycemic index starch (HGIS)/DAG; and HGIS/TAG) for 9 weeks during the weight loss period. At weeks 1 and 8, fasting plasma insulin, glucose, nonesterified fatty acid (NEFA), glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1) were determined. Weight loss did not affect fasting insulin, glucose, and NEFA, but fasting GIP increased and GLP-1 decreased. LGIS affected postprandial insulin at both times and glucose was similar to insulin, except 60 min postprandially with DAG at week 8. NEFA lowering was less with the LGIS diets initially but not thereafter. At 60 min postprandially on week 8, GIP was significantly elevated by DAG, while GLP-1 was increased only with the HD diet. LGIS suppressed insulin and glucose responses up to 180 min postprandially at both sample times. DAG increased incretin hormones as did the DAG/HGIS combination but only at week 8. This latter finding appeared to be related to the glucose response but not to insulin at 60 min.

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“…It is also reported that DAG significantly increases plasma serotonin, which is mostly present in the intestine and mediates thermogenesis, supporting the involvement of DAG in postprandial increases in energy expenditure. Furthermore, DAG ingestion prevents the high-sucrose-diet-induced development of impaired glucose tolerance compared with TAG oil ingestion in male Wistar rats [100]. Upregulated mRNA expressions associated with FFA transport (FFA translocase and FFA binding protein), b-oxidation (acyl-CoA oxidase and medium-chain acyl-CoA dehydrogenase) and thermogenesis (uncoupling protein-2) in the small intestine by DAG may explain in part mechanisms for increased postprandial energy expenditure [101].…”

Section: Diacylglycerol In Metabolic Syndrome and Neurological Disordersmentioning

confidence: 94%

Metabolic syndrome as a risk factor for neurological disorders

Farooqui

Panza

et al. 2011

Cell. Mol. Life Sci.

169

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The metabolic syndrome is a cluster of common pathologies: abdominal obesity linked to an excess of visceral fat, insulin resistance, dyslipidemia and hypertension. At the molecular level, metabolic syndrome is accompanied not only by dysregulation in the expression of adipokines (cytokines and chemokines), but also by alterations in levels of leptin, a peptide hormone released by white adipose tissue. These changes modulate immune response and inflammation that lead to alterations in the hypothalamic 'bodyweight/appetite/satiety set point,' resulting in the initiation and development of metabolic syndrome. Metabolic syndrome is a risk factor for neurological disorders such as stroke, depression and Alzheimer's disease. The molecular mechanism underlying the mirror relationship between metabolic syndrome and neurological disorders is not fully understood. However, it is becoming increasingly evident that all cellular and biochemical alterations observed in metabolic syndrome like impairment of endothelial cell function, abnormality in essential fatty acid metabolism and alterations in lipid mediators along with abnormal insulin/leptin signaling may represent a pathological bridge between metabolic syndrome and neurological disorders such as stroke, Alzheimer's disease and depression. The purpose of this review is not only to describe the involvement of brain in the pathogenesis of metabolic syndrome, but also to link the pathogenesis of metabolic syndrome with neurochemical changes in stroke, Alzheimer's disease and depression to a wider audience of neuroscientists with the hope that this discussion will initiate more studies on the relationship between metabolic syndrome and neurological disorders.

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Effect of diacylglycerol on the development of impaired glucose tolerance in sucrose‐fed rats

Cited by 12 publications

References 55 publications

Dietary 1,3-diacylglycerol protects against diet-induced obesity and insulin resistance

Dietary 1,3-diacylglycerol protects against diet-induced obesity and insulin resistance

Metabolic and Hormonal Alterations with Diacylglycerol and Low Glycemic Index Starch during Canine Weight Loss

Metabolic syndrome as a risk factor for neurological disorders

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