Dietary Chlorella vulgaris modulates the performance, antioxidant capacity, innate immunity, and disease resistance capability of Nile tilapia fingerlings fed on plant-based diets

Abdel‐Tawwab, Mohsen; Mousa, Mamdouh A. A.; Mamoon, Ahmed; Abdelghany, Mohamed F.; Abdel-Hamid, Eman A.A.; Abdel‐Razek, Nashwa; Ali, Fawzia S.; Shady, Sherien H.; Gewida, Ahmed G. A.

doi:10.1016/j.anifeedsci.2021.115181

Cited by 20 publications

(14 citation statements)

References 61 publications

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“…Similarly, our results revealed that CV supplementation showed higher SOD, CAT, and GPX activities with significantly lower MDA values in good agreement with Abdel-Tawwab et al [ 79 ]. Phytochemicals; like tocopherols, chlorophylls, flavonoids, carotenoids, ubiquinone, and polyphenols that have antioxidant properties are extensively included in CV [ 80 ].…”

Section: Discussionsupporting

confidence: 92%

Royal Jelly and Chlorella vulgaris Mitigate Gibberellic Acid-Induced Cytogenotoxicity and Hepatotoxicity in Rats via Modulation of the PPARα/AP-1 Signaling Pathway and Suppression of Oxidative Stress and Inflammation

Khadrawy

Mohamed

Hassan

et al. 2023

Foods

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Gibberellic acid (GA3) is a well-known plant growth regulator used in several countries, but its widespread use has negative effects on both animal and human health. The current study assesses the protective effect of royal jelly (RJ) and Chlorella vulgaris (CV) on the genotoxicity and hepatic injury induced by GA3 in rats. Daily oral administration of 55 mg/kg GA3 to rats for 6 constitutive weeks induced biochemical and histopathological changes in the liver via oxidative stress and inflammation. Co-administration of 300 mg/kg RJ or 500 mg/kg CV with GA3 considerably ameliorated the serum levels of AST (aspartate aminotransferase), ALT (alanine aminotransferase), ALP (alkaline phosphatase), γGT (gamma-glutamyl transferase), total bilirubin, and albumin. Lowered malondialdehyde, tumor necrosis factor α (TNF-α), and nuclear factor κB (NF-κB) levels along with elevated SOD (superoxide dismutase), CAT (catalase), and GPx (glutathione peroxidase) enzyme activities indicated the antioxidant and anti-inflammatory properties of both RJ and CV. Also, they improved the histological structure and reduced cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expressions along with up-regulating peroxisome proliferator activated receptor α (PPARα) and down-regulating activator protein 1 (AP-1) gene expression. Additionally, chromosomal abnormalities and mitotic index were nearly normalized after treatment with RJ and CV. In conclusion, RJ and CV can protect against GA3-induced genotoxicity and liver toxicity by diminishing oxidative stress and inflammation, and modulating the PPARα/AP-1 signaling pathway.

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Section: Discussionsupporting

confidence: 92%

Royal Jelly and Chlorella vulgaris Mitigate Gibberellic Acid-Induced Cytogenotoxicity and Hepatotoxicity in Rats via Modulation of the PPARα/AP-1 Signaling Pathway and Suppression of Oxidative Stress and Inflammation

Khadrawy

Mohamed

Hassan

et al. 2023

Foods

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“…It acted as a hepatoprotective agent (Heneash et al, 2015;Akbary and Aminikhoei, 2018;Ashour et al, 2020). In previous studies with other microalgae, Mahmoud et al (2020) and Abdel-Tawwab et al (2022b) argued that the serum ALAT and ASAT levels declined significantly in the fish because of dietary Chlorella.…”

Section: Discussionmentioning

confidence: 97%

Dual effect of dietary seaweed of extract nanoparticles (GNS) with bionanocomposite cellulose acetate membranes (CA/bio-AgNps) on growth performance and health status of the Nile tilapia (Oreochromis niloticus): Specification on feed utilization, immune system, and antiparasitic action

Radwan

El-Sharkawy²,

Negm³

et al. 2022

Front. Mar. Sci.

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Seaweed draws a lot of attention for its vital role in aquaculture as it contains beneficial biological compounds that undoubtedly might help in the development of this field. The current study sheds light on the potential efficiency of dietary supplements of Grateloupia acuminata and G. doryphore (Halymeniaceae) nanoparticles (GNS) at different levels with bionanocomposite cellulose acetate membranes (CA/bio-AgNps) on improved growth performance, digestive enzyme activity, immunity, antioxidative, resistance against infectious pathogens, and characterization of water quality treated with CA/bio-AgNps that is used in rearing Nile tilapia (Oreochromis niloticus). Four concentrations (0.1, 0.25, 0.5, and 1.0 ml/L) of GNS extract were tested as potential anti-bacterial and for the efficacy of being parasitic. Fish with an average weight (24.46 ± 0. 50 g) were apportioned into six experimental groups (T0, T1, T2, T3, T4, and T5) represented as 0.0%, 0.0%, 0.1%, 0.25%, 0.5%, and 1.0% GNS in diets with CA/bio-AgNps, respectively. Injection of fish with Aeromonas hydrophila was performed at the end of the trial. Chemical and bacteriological water indices significantly showed improvement after being treated with CA/bio-AgNps than the control group. Growth, carcass composition, digestive enzyme, and hematological and biochemical indices were significantly noticed positive (p< 0.05), especially T4 and T5, than the control group. In parallel, a significant improvement was noticed in serum lysozyme, total immunoglobulin, complement C3, antioxidative enzyme, and the relative expression of hepatic and inflammatory genes with an increased level of GNS (p< 0.05) are upregulated than the control group. Remarkably, GNS-supplemented diets and extracts provided positive efficacy against A. hydrophila with a decreased percentage of fish mortality, besides efficacy on antibacterial strains and Cichlidogyrus tilapiae, respectively. To sum up, the seaweed extract with CA/bio-AgNps resulted in better growth performance of fish, antipathogenic effect, and health status. Furthermore, CA/bio-AgNps were vital in improving water characteristics. They should be studied and applied more in the future.

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“…For instance, supplemented Koi carp ( C. carpio ) with C. vulgaris had higher values of blood parameters (Hb, Ht, RBCs and WBCs), levels of IgM, lysozyme and C4 complement activities in serum, showing that 5% of dietary supplementation was the optimum dose 50 . Also, C. vulgaris was administered to Nile tilapia fish with doses of 2.5 g up to 20 g kg −1 of feed for 70 days, promoting development, serum activity of SOD, CAT, GPx, lysozyme, RB and bactericidal capacity against Aeromonas hydrophila , Pseudomonas fluorescens and Vibrio anguillarum 56 . Another species used to test its immunostimulatory capacity was C. sorokiniana , where Chen et al 57 supplemented rainbow trout fish with the microalgae at 5% and 10% for 90 days.…”

Section: Immunomodulatory Effects Of Dietary Microalgae In Fishmentioning

confidence: 99%

Microalgae with immunomodulatory effects on fish

Bahi

Ramos‐Vega

Angulo

et al. 2023

Reviews in Aquaculture

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In recent decades, microalgal biotechnology has become one of the most valuable sources of functional feed additives. Many microalgae, such as Chlorella sp., Tetraselmis sp., Navicula sp., Phaeodactylum tricornutum, Porphyridium cruentum, Nannochloropsis gaditana, Dunaliella salina, Lobosphaera sp. and Schizochytrium sp., have been considered valuable in fish species as they enhance immunostimulant abilities, resistance against infectious diseases and tolerance to environmental stress. For instance, immunological parameters (i.e., respiratory burst activity, phagocytic capacity and IgM production) and immune‐related gene expression (i.e., proinflammatory cytokines) in fish have been manly analysed, demonstrating modulation upon microalgal administration. Moreover, disease resistance to microbial pathogen challenges has also been evidenced in several studies. In this context, the present literature review aims to assemble and reveal published research about the immunostimulant properties of some microalgae and their compounds in the immune systems of farmed fish species, whether model or new, with a high potential for aquaculture. Overall, it remains unclear how microalgae or their bioactive compounds may induce or modulate signals in the immune systems of fish species; however, the inclusion of different microalgal species in fish feed has improved the immune response and increased survival to stress conditions and infectious challenges.

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Dietary Chlorella vulgaris modulates the performance, antioxidant capacity, innate immunity, and disease resistance capability of Nile tilapia fingerlings fed on plant-based diets

Cited by 20 publications

References 61 publications

Royal Jelly and Chlorella vulgaris Mitigate Gibberellic Acid-Induced Cytogenotoxicity and Hepatotoxicity in Rats via Modulation of the PPARα/AP-1 Signaling Pathway and Suppression of Oxidative Stress and Inflammation

Royal Jelly and Chlorella vulgaris Mitigate Gibberellic Acid-Induced Cytogenotoxicity and Hepatotoxicity in Rats via Modulation of the PPARα/AP-1 Signaling Pathway and Suppression of Oxidative Stress and Inflammation

Dual effect of dietary seaweed of extract nanoparticles (GNS) with bionanocomposite cellulose acetate membranes (CA/bio-AgNps) on growth performance and health status of the Nile tilapia (Oreochromis niloticus): Specification on feed utilization, immune system, and antiparasitic action

Microalgae with immunomodulatory effects on fish

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