Dietary chickpeas reverse visceral adiposity, dyslipidaemia and insulin resistance in rats induced by a chronic high-fat diet

Yang, Ying; Zhou, Libin; Gu, Yuanjun; Zhang, Hongjie; Tang, Junling; Li, Fengying; Shang, Wenbin; Jiang, Boren; Yue, Xiaohua; Chen, Ming-Dao

doi:10.1017/s0007114507750870

Cited by 65 publications

(73 citation statements)

References 38 publications

(42 reference statements)

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“…LPL is a key enzyme involved in metabolism and transport of lipid (Wang and Eckel 2009). Several reports have shown that reduction of adipose deposition is caused by decreasing LPL mRNA expression levels (Naaz et al 2003;Yang et al 2007). DGAT1 is the enzyme which catalyzes the final step in the TG synthesis pathway and considered to play key regulatory role in TG synthesis (Chen and Farese 2000).…”

Section: Discussionmentioning

confidence: 99%

Effects of Korean white ginseng extracts on obesity in high-fat diet-induced obese mice

et al. 2010

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The present study examined the antiobesity effect and mechanism of action of Korean white ginseng extracts (KGE) using high-fat diet (HFD)-induced obese mice. Mice were fed a low-fat diet (LFD), HFD or HFD containing 0.8 and 1.6% (w/ w) KGE diet (HFD ? 0.8KGE and HFD ? 1.6KGE) for 8 weeks. We also examined the effects of KGE on plasma triglyceride (TG) elevation in mice administrated with oral lipid emulsion. Body weight gain and white adipose tissue (WAT) weight were significantly decreased in the HFD ? 1.6KGE group, compared with the HFD group. The plasma TG levels were also significantly reduced in both HFD ? 0.8KGE and HFD ? 1.6KGE groups, while leptin levels were significantly decreased in only the HFD ? 1.6KGE group, compared with the HFD group. The HFD ? 1.6KGE group showed significantly lower mRNA levels of lipogenesis-related genes, including peroxisome proliferator-activated receptorc2 (PPARc2), sterol regulatory element binding protein-1c (SREBP-1c), lipoprotein lipase (LPL), fatty acid synthase (FAS) and diacylglycerol acyltransferase 1 (DGAT1), compared with the HFD group. In addition, a dose of 1000 mg/kg KGE inhibited the elevation of plasma TG levels compared with mice given the lipid emulsion alone. These results suggest that the anti-obesity effects of KGE may be elicited by regulating expression of lipogenesis-related genes in WAT and by delaying intestinal fat absorption.

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Section: Discussionmentioning

confidence: 99%

Effects of Korean white ginseng extracts on obesity in high-fat diet-induced obese mice

et al. 2010

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“…Cross-sectional analysis of NHANES 2003–2010 did not show any cross-sectional association with fasting insulin or glucose levels in those who reported consuming chickpea/hummus intake vs. non-consumers [12]. Yang et al showed that chickpeas significantly improve insulin resistance and prevent post-prandial hyperglycemia and hyperinsulinemia induced by a chronic high-fat diet in rats [29]. Likewise, emerging epidemiological evidence shows that pulse consumption is associated with a decreased risk for type-2 diabetes [30,31].…”

Section: Health Outcomes Associated With Consumption Of Chickpeas mentioning

confidence: 99%

The Nutritional Value and Health Benefits of Chickpeas and Hummus

Wallace

Murray

Zelman³

2016

Nutrients

177

101

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The 2015–2020 Dietary Guidelines for Americans advocate for increasing vegetable intake and replacing energy-dense foods with those that are nutrient-dense. Most Americans do not eat enough vegetables, and particularly legumes, each day, despite their well-established benefits for health. Traditional hummus is a nutrient-dense dip or spread made from cooked, mashed chickpeas, blended with tahini, olive oil, lemon juice, and spices. Consumers of chickpeas and/or hummus have been shown to have higher nutrient intakes of dietary fiber, polyunsaturated fatty acids, vitamin A, vitamin E, vitamin C, folate, magnesium, potassium, and iron as compared to non-consumers. Hummus consumers have also been shown to have higher Healthy Eating Index 2005 (HEI-2005) scores. This may be, in part, due to hummus’ higher Naturally Nutrient Rich (NNR) score as compared to other dips and spreads. Emerging research suggests that chickpeas and hummus may play a beneficial role in weight management and glucose and insulin regulation, as well as have a positive impact on some markers of cardiovascular disease (CVD). Raw or cooked chickpeas and hummus also contain dietary bioactives such as phytic acid, sterols, tannins, carotenoids, and other polyphenols such as isoflavones, whose benefits may extend beyond basic nutrition requirements of humans. With chickpeas as its primary ingredient, hummus—and especially when paired with vegetables and/or whole grains—is a nutritious way for Americans to obtain their recommended servings of legumes. This manuscript reviews the nutritional value and health benefits of chickpeas and hummus and explores how these foods may help improve the nutrient profiles of meals.

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“…Beneficial effects on fat distribution by pulse consumption are supported by previous studies in animals and humans [22–24]. A suggested mechanism is the oestrogen effect of the phyto-estrogens in pulses [25] which is expected to be greater in women than men.…”

Section: Discussionmentioning

confidence: 62%

High consumption of pulses is associated with lower risk of abnormal glucose metabolism in women in Mauritius

et al. 2014

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Aims To investigate if consumption of pulses was associated with a reduced risk of developing abnormal glucose metabolism, increases in body weight and increases in waist circumference in a multi-ethnic cohort in Mauritius. Methods Population-based surveys were performed in Mauritius in 1992 and in 1998. Pulse consumption was estimated from a food frequency questionnaire in 1992 and outcomes were measured in 1998. At both time points, anthropometry was undertaken and an oral glucose tolerance test was performed. Results Mauritian women with the highest consumption of pulses (highest tertile) had a reduced risk of developing abnormal glucose metabolism [odds ratio 0.52; 95% CI 0.27, 0.99) compared with those with the lowest consumption, and also after multivariable adjustments. In women, a high consumption of pulses was associated with a smaller increase in BMI. Conclusions High consumption of pulses was associated with a reduced risk of abnormal glucose metabolism and a smaller increase in BMI in Mauritian women. Promotion of pulse consumption could be an important dietary intervention for the prevention of Type 2 diabetes and obesity in Mauritius and should be examined in other populations and in clinical trials.

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Dietary chickpeas reverse visceral adiposity, dyslipidaemia and insulin resistance in rats induced by a chronic high-fat diet

Cited by 65 publications

References 38 publications

Effects of Korean white ginseng extracts on obesity in high-fat diet-induced obese mice

Effects of Korean white ginseng extracts on obesity in high-fat diet-induced obese mice

The Nutritional Value and Health Benefits of Chickpeas and Hummus

High consumption of pulses is associated with lower risk of abnormal glucose metabolism in women in Mauritius

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