Dietary Carbohydrates Impair Healthspan and Promote Mortality

Ravichandran, Meenakshi; Grandl, Gerald; Ristow, Michael

doi:10.1016/j.cmet.2017.09.011

Cited by 15 publications

(11 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Together with other evidences, including numerous animal studies, a serious demand for strategies on how to counteract carbohydrate overload is indicated. Different approaches, including pharmacological interventions [27] as well as public health and food regulation policies, are increasingly discussed in the literature [28]. The careful evaluation of multiplicity of factors must be in place in order to determine the optimal nutritional pattern for health preservation and the prevention of age-related diseases.…”

Section: The Epidemiological Evidence Of Glucose Overload In Human Pomentioning

confidence: 99%

Glucose as a Major Antioxidant: When, What for and Why It Fails?

et al. 2020

View full text Add to dashboard Cite

A human organism depends on stable glucose blood levels in order to maintain its metabolic needs. Glucose is considered to be the most important energy source, and glycolysis is postulated as a backbone pathway. However, when the glucose supply is limited, ketone bodies and amino acids can be used to produce enough ATP. In contrast, for the functioning of the pentose phosphate pathway (PPP) glucose is essential and cannot be substituted by other metabolites. The PPP generates and maintains the levels of nicotinamide adenine dinucleotide phosphate (NADPH) needed for the reduction in oxidized glutathione and protein thiols, the synthesis of lipids and DNA as well as for xenobiotic detoxification, regulatory redox signaling and counteracting infections. The flux of glucose into a PPP—particularly under extreme oxidative and toxic challenges—is critical for survival, whereas the glycolytic pathway is primarily activated when glucose is abundant, and there is lack of NADP+ that is required for the activation of glucose-6 phosphate dehydrogenase. An important role of glycogen stores in resistance to oxidative challenges is discussed. Current evidences explain the disruptive metabolic effects and detrimental health consequences of chronic nutritional carbohydrate overload, and provide new insights into the positive metabolic effects of intermittent fasting, caloric restriction, exercise, and ketogenic diet through modulation of redox homeostasis.

show abstract

Section: The Epidemiological Evidence Of Glucose Overload In Human Pomentioning

confidence: 99%

Glucose as a Major Antioxidant: When, What for and Why It Fails?

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In a recent study, named PURE, Ravichandran's group showed that in a pool of over 135,000 patients from 18 countries nutritive carbohydrates increase human mortality, whereas dietary fat reduces it, thus leading to the novel concept of requesting a fundamental change of current nutritional guidelines. Concurrently, experimental evidence from animal models provided synergizing mechanistic concepts and pharmacological options to mimic low-carb or KDs [51]. Back in 2012, Okuda investigated whether the improvement in hyperglycemia by dietary control influenced hyperglycemia-induced pathologies in tissues of juvenile obese mice.…”

Section: Use Of Ketogenic Diet In Diabetes Type IImentioning

confidence: 99%

The Ketogenic Diet and its Clinical Applications in Type I and II Diabetes

Pilla¹

2018

Int J Diabetes Clin Res

View full text Add to dashboard Cite

show abstract

“…Even though carbohydrates became more available, any possible overload would rather not take place considering high physical activity of most of the people at that time. Thus, gradual increase in basic food availability and elimination of physical work created a massive nutritional carbohydrate overload at the organism's level causing respective health consequences [24]. Consistent with this, recently a metabolic core model was used to evaluate how increased glycolytic utilization of glucose together with glutamine-dependent lactate production promotes cancer growth [30].…”

Section: The Evidence Of Pandemic Glucose Toxicity In Human Populatiomentioning

confidence: 99%

“…A recent large-scale epidemiological cohort study pointed out that high carbohydrate consumption is a major factor for all-cause mortality, while total fat and different types of fat were not associated with increased mortality. Thus, authors question current dietary guidelines suggesting an urgent need for their reconsideration [24]. Together with other evidence, including numerous animal studies, a serious demand for strategies of how to counteract carbohydrate overload is indicated.…”

Section: The Evidence Of Pandemic Glucose Toxicity In Human Populatiomentioning

confidence: 99%

Glucose as a Major Antioxidant: When, What for and Why It Fails?

Cherkas¹,

Holota²,

Mdzinarashvili³

et al. 2019

Preprint

View full text Add to dashboard Cite

A human organism depends on stable glucose blood levels in order to maintain the metabolic needs. Glucose is considered as the most important energy source and glycolysis is postulated as a backbone pathway. However, when glucose supply is limited, ketone bodies and amino acids can be used to produce enough ATP. In contrast, for the functioning of pentose phosphate pathway (PPP) glucose is essential and cannot be substituted for by other metabolites. PPP generates and maintains levels of NADPH needed for reduction of oxidized glutathione and protein thiols, synthesis of lipids and DNA as well as for xenobiotics detoxification, regulatory redox signaling and counteracting infections. Flux of glucose into a PPP, particularly under extreme oxidative and toxic challenges is critical for survival, whereas the glycolytic pathway is primarily activated when glucose is abundant, and there is lack of NADP+ that is required for activation of glucose-6 phosphate dehydrogenase. An important role of glycogen stores in resistance to oxidative challenges is discussed. Current evidence explains disruptive metabolic effects and detrimental health consequences of chronic nutritional carbohydrate overload and provides new insights into positive metabolic effects of intermittent fasting, caloric restriction, exercise, and ketogenic diet through modulation of redox homeostasis.

show abstract

Dietary Carbohydrates Impair Healthspan and Promote Mortality

Cited by 15 publications

References 12 publications

Glucose as a Major Antioxidant: When, What for and Why It Fails?

Glucose as a Major Antioxidant: When, What for and Why It Fails?

The Ketogenic Diet and its Clinical Applications in Type I and II Diabetes

Glucose as a Major Antioxidant: When, What for and Why It Fails?

Contact Info

Product

Resources

About