Dietary carbohydrate intake and mortality: a prospective cohort study and meta-analysis

Seidelmann, Sara B.; Claggett, Brian; Cheng, Susan; Henglin, Mir; Shah, Amil M.; Steffen, Lyn M.; Folsom, Aaron R.; Rimm, Eric B.; Willett, Walter C.; Solomon, Scott D.

doi:10.1016/s2468-2667(18)30135-x

Cited by 562 publications

(433 citation statements)

References 27 publications

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“…There are two results from the Lancet below, (Dehghan et al, 2017;Seidelmann et al, 2018). Similar conclusions have been made.…”

Section: The Influences Of Ratio Of Carbohydrate and Fat In Dietssupporting

confidence: 64%

“…From Hu et al (2018), the results stated that only fats caused adiposity of mice, intake of carbohydrate and fats were irrelevant of that. This result differs from the other two studies (Dehghan et al, 2017;Seidelmann et al, 2018). These two cohort studies aimed to investigate the association of ratio of macro-nutrients with mortality.…”

Section: The Influences Of Ratio Of Carbohydrate and Fat In Animal Momentioning

confidence: 58%

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Influences of ratio of macro-nutrients intake to human and animals: an overview

Song

Wang

Chen

et al. 2019

Food and Agricultural Immunology

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High-fat/high-carbohydrate diets have been proved to be associated with series metabolic syndromes and can lead to noncommunicable diseases. In this paper, recent cohort studies and animal experiments about the influences of macro-nutrients (carbohydrate, fat and protein) with different ratios to organisms were overviewed. The results based on meta-analysis and animal experiment were further analysed to illustrate the relationships between diet and health-related problems, such as immune and inflammatory response, insulin resistance, diabetes, obesity, cardiovascular diseases, organ damages and mortality. We expect the review will provide useful evidences for dietary guideline and revision. ARTICLE HISTORY

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“…There are two results from the Lancet below, (Dehghan et al, 2017;Seidelmann et al, 2018). Similar conclusions have been made.…”

Section: The Influences Of Ratio Of Carbohydrate and Fat In Dietssupporting

confidence: 64%

Section: The Influences Of Ratio Of Carbohydrate and Fat In Animal Momentioning

confidence: 58%

Influences of ratio of macro-nutrients intake to human and animals: an overview

Song

Wang

Chen

et al. 2019

Food and Agricultural Immunology

View full text Add to dashboard Cite

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“…Trans-fat To avoid [12,149,150] Saturated fat -<10% *, -<7% * when hypercholesterolaemia is present [12,19,149,150] Dietary cholesterol -<300 mg/day (especially when plasma cholesterol levels are elevated) -notice there is an individual variation of how dietary cholesterol may influence serum cholesterol [19,151] Total fat intake -Large range of total fat intake; <30% according to WHO guidelines -Fat intake >35% * is not recommended -Not too low (due to possible vitamin E deficiency which may advance to a reduction of HDL-C) -…”

Section: Variable Recommendation Referencementioning

confidence: 99%

Non-Systematic Review of Diet and Nutritional Risk Factors of Cardiovascular Disease in Obesity

et al. 2020

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Although cardiovascular disease and its risk factors have been widely studied and new methods of diagnosis and treatment have been developed and implemented, the morbidity and mortality levels are still rising-cardiovascular disease is responsible for more than four million deaths each year in Europe alone. Even though nutrition is classified as one of the main and changeable risk factors, the quality of the diet in the majority of people does not follow the recommendations essential for prevention of obesity and cardiovascular disease. It demonstrates the need for better nutritional education in cardiovascular disease prevention and treatment, and the need to emphasize dietary components most relevant in cardiovascular disease. In our non-systematic review, we summarize the most recent knowledge about nutritional risk and prevention in cardiovascular disease and obesity.

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“…Since zonulin is the precursor of haptoglobin (51), which was lowered after 28 weeks, a third alternative is that the increased zonulin levels represent an arrest in the pathway to develop the fully expression of haptoglobin. However, recent research has shown that low carbohydrate content (<50-55%) increases mortality compared to medium carbohydrate content usually present in Nordic diet (26,49,52). The increased zonulin levels observed after this low carbohydrate diet may be a key point in this higher mortality risk, since zonulin is supposed to be a biomarker of unhealthy conditions (4,50).…”

Section: Mechanisms Behind the Improved Anthropometry And Metabolismmentioning

confidence: 97%

An Okinawan‑based Nordic diet improves glucose and lipid metabolism in health and type 2 diabetes, in alignment with changes in the endocrine profile, whereas zonulin levels are elevated (Review)

Ohlsson

2019

Exp Ther Med

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The Okinawan-based Nordic diet has been developed to improve glucose metabolism. The aim of the present study was to summarize all anthropometric, subjective, and biochemical findings obtained following two different studies investigating this diet. The diet was administered i) as a single breakfast to healthy volunteers and ii) as a 12-week dietary intervention to patients with type 2 diabetes. The degree of satiety, sweet cravings, gastrointestinal symptoms, and health-related quality of life were estimated. Weight and blood pressures of participants were measured, and analyses including circulating levels of inflammatory and metabolic biomarkers, hormones, and short-chain fatty acids (SCFA), and microbial diversity and amount of Enterobacteriaceae in feces, were performed. A single breakfast of the diet increased satiety (P<0.001), improved glucose homeostasis (P<0.001), and lowered levels of glucose-dependent insulinotropic polypeptide (GIP) (P=0.002), compared with a standard breakfast. A 12-week intervention in type 2 diabetes increased satiety and decreased sweet cravings, at the same time as health-related quality of life and gastrointestinal symptoms were improved. There were reductions in body mass index (P<0.001), waist circumference (P<0.001), and levels of glucose (P<0.001), cholesterol (P<0.001), and triglycerides (P=0.009), in alignment with the endocrine profile. These improvements were maintained at follow-up 16 weeks later, along with lower levels of ghrelin (P=0.012), polypeptide YY (P=0.002), and visfatin (P=0.021), compared with the parameters recorded at the study start. Levels of haptoglobin, interleukin-18 and thrombocytes were lowered, whereas some other inflammatory biomarkers were unaffected and zonulin levels elevated. Gut microbiota and SCFAs levels were mainly unaffected. The mechanisms governing the anthropometric and metabolic improvements appear to be mediated through alterations in the endocrine profile, yet not in the gut microbiota.

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Dietary carbohydrate intake and mortality: a prospective cohort study and meta-analysis

Abstract: National Institutes of Health.

Cited by 562 publications

References 27 publications

Influences of ratio of macro-nutrients intake to human and animals: an overview

Influences of ratio of macro-nutrients intake to human and animals: an overview

Non-Systematic Review of Diet and Nutritional Risk Factors of Cardiovascular Disease in Obesity

An Okinawan‑based Nordic diet improves glucose and lipid metabolism in health and type 2 diabetes, in alignment with changes in the endocrine profile, whereas zonulin levels are elevated (Review)

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