Dietary boron as a physiological regulator of the normal inflammatory response: A review and current research progress

Hunt, Curtiss D.; Idso, Joseph P.

doi:10.1002/(sici)1520-670x(1999)12:3<221::aid-jtra6>3.0.co;2-x

Cited by 145 publications

(99 citation statements)

References 36 publications

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“…On the contrary, it has been shown that pretreatment with boron (as borax) could replenish the depleted level of GSH, with a concomitant decrease in LPO (Pawa and Ali 2006). This finding corroborates the recently reported evidence that boron itself is not an antioxidant, but is thought to strengthen the antioxidant defense system of the tissue (Hunt and Idso 1999).…”

Section: Discussionsupporting

confidence: 88%

“…Boron deficiency and supplementation exert measurable biological effects in human and animal tissues (in osteoporosis, arthritis, plasma lipid profiles and brain function) (Devirian and Volpe 2003). Boric acid (BA) and Borax (BX) are able to strengthen the tissue antioxidant defenses (Hunt and Idso 1999;Pawa and Ali 2006). Boron compounds also show no potential for genotoxicity in cultured mammalian cells (Turkez et al , 2010aGeyikoglu and Turkez 2008;Turkez 2008).…”

Section: Introductionmentioning

confidence: 99%

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In vitro studies on chemoprotective effect of borax against aflatoxin B1-induced genetic damage in human lymphocytes

et al. 2012

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A common dietary contaminant, aflatoxin B1 (AFB1), has been shown to be a potent mutagen and carcinogen in humans and many animal species. Since the eradication of AFB1 contamination in agricultural products has been rare, the use of natural or synthetic free radical scavengers could be a potential chemopreventive strategy. Boron compounds like borax (BX) and boric acid are the major components of industry and their antioxidant role has recently been reported. In the present report, we evaluated the capability of BX to inhibit the rate of micronucleus (MN) and sister chromatid exchange (SCE) formations induced by AFB1. There were significant increases (P \ 0.05) in both SCE and MN frequencies of cultures treated with AFB1 (3.12 ppm) as compared to controls. However, co-application of BX (1, 2 and 5 ppm) and AFB1 resulted in decreases of SCE and MN rates as compared to the group treated with AFB1 alone. Borax gave 30-50 % protection against AFB1 induced SCEs and MNs. In conclusion, the support of borax was especially useful in aflatoxintoxicated blood tissue. Thus, the risk on target tissues of AFB1 could be reduced and ensured early recovery from its toxicity.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

In vitro studies on chemoprotective effect of borax against aflatoxin B1-induced genetic damage in human lymphocytes

et al. 2012

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“…Endogenous H 2 O 2 is converted to H 2 O by catalase (Svistunenko 2005). The CAT activity protects lipids and proteins against peroxide radicals in erythrocyte membranes (Hunt and Idso 1999). The rising of activities of antioxidant enzymes after BA administration indicates that this action of BA may be mediated via a nuclear BA receptor with a subsequent action on gene expression.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, it is used as a pesticide and food preservative against plant fungicides (Turkoglu 2007). BA having antimicrobial activity (De Seta et al 2009), is able to strengthen the tissue antioxidant defenses via a yet unidentified mechanism that may involve changes in oxidative metabolism (Hunt and Idso 1999;Pawa and Ali 2006). BA also shows minimal potential for genotoxicity in bacteria and cultured mammalian cells (Moore and Expert Scientific Comittee 1997).…”

Section: Introductionmentioning

confidence: 99%

Boric acid: a potential chemoprotective agent against aflatoxin b1 toxicity in human blood

Türkez

Geyikoğlu

2010

Cytotechnology

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Aflatoxin B 1 is the most potent pulmonary and hepatic carcinogen. Since the eradication of Aflatoxin B 1 contamination in agricultural products has been difficult, the use of natural or synthetic free radical scavengers could be a potential chemopreventive strategy. Boric acid is the major component of industry and its antioxidant role has recently been reported. The present study assessed, for the first time, the effectiveness of boric acid following exposure to Aflatoxin B 1 on human whole blood cultures. The biochemical characterizations of glutathione and some enzymes have been carried out in erythrocytes. Alterations in malondialdehyde level were determined as an index of oxidative stress. The sister-chromatid exchange and micronucleus tests were performed to assess DNA damages in lymphocytes. Aflatoxin B 1 treatment significantly reduced the activities of antioxidants by increasing malondialdehyde level (30.53 and 51.43%) of blood, whereas, the boric acid led to an increased resistance of DNA to oxidative damage induced by Aflatoxin B 1 in comparison with control values (P \ 0.05). In conclusion, the support of boric acid was especially useful in Aflatoxin-toxicated blood. Thus the risk on tissue targeting of Aflatoxin B 1 could be reduced ensuring early recovery from its toxicity.

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“…Boron is present in body tissues and fluids mostly as boric acid, B(OH) 3 (Hunt, 1998). Serine proteases are reversibly inhibited by simple and substituted boric acid compounds (Hunt and Idso, 1999). Barranco and Eckhert (2004) and Gallardo-Williams et al (2003) reported that boric acid inhibits human prostate cancer cell proliferation.…”

Section: Introductionmentioning

confidence: 99%

Effects of dietary boron on cervical cytopathology and on micronucleus frequency in exfoliated buccal cells

Korkmaz

Uzgören

Bakırdere

et al. 2007

Environmental Toxicology

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Recent evidence indicates that boron and borates may have anticarcinogenic properties. In this study, we have investigated the incidence of adverse cytological findings in cervical smears and the micronucleus (MN) frequency in women living in boron-rich and boron-poor regions. Cervical smears were prepared from 1059 women with low socioeconomic status; 472 of the women lived in relatively boronrich rural areas, while 587 lived in relatively boron-poor regions. The average and standard deviation values for the age of the women screened with the cervical Pap smear test were 41.55 6 8.38. The mean dietary intake of boron was 8.41 mg/day for women from the boron-rich regions, and 1.26 mg/day for women living in the boron-poor regions (P < 0.0001). Women from the boron-rich regions had no cytopathological indications of cervical cancer, while there were cytopathological findings for 15 women from the boronpoor areas ( 2 ¼ 10.473, P < 0.05). Sixty women, 30 from each region, were chosen for evaluating MN frequencies in exfoliated buccal cells. MN frequencies for women from the boron-rich and boron-poor regions were not significantly different (t ¼ À0.294, P > 0.05). Also, there were no significant correlations between age and MN frequency for women from both the boron-rich (r ¼ 0.133, P ¼ 0.48, P > 0.05) and boron-poor (r ¼ À0.033, P ¼ 0.861, P > 0.05) regions. The results suggest that ingestion of boron in the drinking water decreases the incidence of cervical cancer-related histopathological findings. There was no correlation between the pathological findings from the cervical smears and buccal cell MN frequency suggesting that the two study populations were exposed equally to gentotoxic agents. Nonetheless, cervical cancer-related histopathological findings should be validated by other researchers. # 2007 Wiley Periodicals, Inc. Environ Toxicol 22: 17-25, 2007.

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Dietary boron as a physiological regulator of the normal inflammatory response: A review and current research progress

Cited by 145 publications

References 36 publications

In vitro studies on chemoprotective effect of borax against aflatoxin B1-induced genetic damage in human lymphocytes

In vitro studies on chemoprotective effect of borax against aflatoxin B1-induced genetic damage in human lymphocytes

Boric acid: a potential chemoprotective agent against aflatoxin b1 toxicity in human blood

Effects of dietary boron on cervical cytopathology and on micronucleus frequency in exfoliated buccal cells

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