Dietary bioactive compounds as modulators of mitochondrial function

Vasquez-Reyes, Sarai; Velázquez-Villegas, Laura A.; Vargas‐Castillo, Ariana; Noriega, Lilia G.; Torres, Nimbe; Tovar, Armando R.

doi:10.1016/j.jnutbio.2021.108768

Cited by 20 publications

(15 citation statements)

References 166 publications

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“…Phenolic compounds have a high antioxidant potential, acting as inhibitors of free radicals and metal ion chelating, slowing and preventing oxidative stress. They are composed of one or more aromatic rings with one or more hydroxyl and can be classified according to groups attached to their structure in flavonoids and nonflavonoids can be classified according to groups attached to their structure in flavonoids and nonflavonoids (Patra et al, 2021; Vásquez‐Reyes et al, 2021).…”

Section: Bioactive Compoundsmentioning

confidence: 99%

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Extraction and encapsulation of bioactive compounds: A review

Peixoto

Aranha

Nardino

et al. 2022

J Food Process Engineering

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The purposes of this article are to address the different bioactive compounds present in plant matrices, emphasizing the importance in choosing the extraction method in the yield and quality of extracted compounds, using techniques to determine antioxidant activity. As well as to expose the main mathematical models used in the kinetic study for process optimization and the influence of encapsulation on the conservation of bioactive compounds. Bioactive compounds are chemical molecules that have medicinal properties, acting in the prevention of diseases. The wide variety of bioactive compounds present in plants determines their characteristics, and the different combinations of these phytochemicals confer the particularities of each matrix. The extraction of compounds is extremely important, due to their industrial applications, being widely used in the production of food, supplements, cosmetics, and medicines, as ingredients or additives of these products. It was observed that new technologies are able to improve extraction efficiency obtaining higher yields and antioxidant activity than conventional methods. To obtain the extraction mechanism, aiming at optimizing time, several empirical kinetic models are used. The employability of mathematical models helps in the kinetic extraction profile, verifying the extraction profile of antioxidant compounds. Among these models, Hyperbolic was the one that best adapted to the studies performed. Then, for the preservation of the bioactive compounds obtained in the extraction process, encapsulation is carried out. This process prevents the degradation of compounds caused by external conditions such as light, heat, humidity, and increase in desirable properties, decreasing the evaporation of trapped active agents.

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Section: Bioactive Compoundsmentioning

confidence: 99%

“…Among the nonflavonoids are coumarins, stilbenes, tannins, and phenolic acids. Phenolic acids have complex structures and are divided into hydroxybenzoic acid and hydroxycinnamic acid derivatives (Banwo et al, 2021; Vásquez‐Reyes et al, 2021).…”

Section: Bioactive Compoundsmentioning

confidence: 99%

Extraction and encapsulation of bioactive compounds: A review

Peixoto

Aranha

Nardino

et al. 2022

J Food Process Engineering

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“…The gut microbiome is a key player in energy and metabolic homeostasis in humans and has dynamic effects that are still being appreciated. One aspect of the microbiome’s contribution to human health and well-being is its interaction with dietary intake, leading to physiological effects such as the alteration of the chemical structure of ingested food components and the modulation of human metabolism in the body ( 1 ). Dietary intake can also change the compositions and/or metabolic activities of the microbiome ( 1 – 3 ).…”

Section: Commentarymentioning

confidence: 99%

“…One aspect of the microbiome’s contribution to human health and well-being is its interaction with dietary intake, leading to physiological effects such as the alteration of the chemical structure of ingested food components and the modulation of human metabolism in the body ( 1 ). Dietary intake can also change the compositions and/or metabolic activities of the microbiome ( 1 – 3 ). How these effects might be involved in the actions of ingested nutritional compositions is a topic of heightened interest.…”

Section: Commentarymentioning

confidence: 99%

Metabolic Disease, NAD Metabolism, Nicotinamide Riboside, and the Gut Microbiome: Connecting the Dots from the Gut to Physiology

Sauve

2022

mSystems

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“…Emerging evidence shows dietary bioactive compounds modulate gut health, intestinal barrier function [ 9 , 10 ], and mitochondrial activity, representing a novel option to modulate energy expenditure and energetic metabolism in cells and tissues [ 5 , 11 ]. Gingerol-enriched-ginger (GEG) with antioxidant and anti-inflammatory properties has been reported to improve glucose metabolism and enhance insulin sensitivity in diabetic animals [ 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Ginger Root Extract Improves GI Health in Diabetic Rats by Improving Intestinal Integrity and Mitochondrial Function

Wang

Santos²,

Dufour³

et al. 2022

Nutrients

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Background Emerging research suggests hyperglycemia can increase intestinal permeability. Ginger and its bioactive compounds have been reported to benefit diabetic animals due to their anti-inflammatory and antioxidant properties. In this study, we revealed the beneficial effect of gingerol-enriched ginger (GEG) on intestinal health (i.e., barrier function, mitochondrial function, and anti-inflammation) in diabetic rats. Methods Thirty-three male Sprague Dawley rats were assigned to three groups: low-fat diet (control group), high-fat-diet (HFD) + streptozotocin (single low dose 35 mg/kg body weight (BW) after 2 weeks of HFD feeding) (DM group), and HFD + streptozotocin + 0.75% GEG in diet (GEG group) for 42 days. Glucose tolerance tests (GTT) and insulin tolerance tests (ITT) were conducted at baseline and prior to sample collection. Total pancreatic insulin content was determined by ELISA. Total RNA of intestinal tissues was extracted for mRNA expression using qRT-PCR. Results Compared to the DM group, the GEG group had improved glucose tolerance and increased pancreatic insulin content. Compared to those without GEG (DM group), GEG supplementation (GEG group) increased the gene expression of tight junction (Claudin-3) and antioxidant capacity (SOD1), while it decreased the gene expression for mitochondrial fusion (MFN1), fission (FIS1), biogenesis (PGC-1α, TFAM), mitophagy (LC3B, P62, PINK1), and inflammation (NF-κB). Conclusions Ginger root extract improved glucose homeostasis in diabetic rats, in part, via improving intestinal integrity and mitochondrial dysfunction of GI health.

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Dietary bioactive compounds as modulators of mitochondrial function

Cited by 20 publications

References 166 publications

Extraction and encapsulation of bioactive compounds: A review

Extraction and encapsulation of bioactive compounds: A review

Metabolic Disease, NAD Metabolism, Nicotinamide Riboside, and the Gut Microbiome: Connecting the Dots from the Gut to Physiology

Ginger Root Extract Improves GI Health in Diabetic Rats by Improving Intestinal Integrity and Mitochondrial Function

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