“…This is true both for patients with a first stone event and for those with recurrent urolithiasis. The recurrence rate is significantly reduced by targeted treatment (10-15% vs. 50-80%) (39,40).…”
Section: Ammonium Uratementioning
confidence: 99%
“…If the basic diagnostic measures confirm a stone patient's classification as uncomplicated, this metabolic screening need not be carried out. General urinary stone metaphylaxis with regular follow-ups is sufficient (6,36,37,39).…”
Urolithiasis has many causes and can be treated in many different ways. An extensive metabolic work-up is often necessary for secondary prevention. The various treatment options must be considered for their suitability in each individual patient. Robust data are now available on surgical and interventional methods, but there are as yet no high-quality trials of secondary prevention. Further research should concentrate on the etiology and pathogenesis of urolithiasis.
“…This is true both for patients with a first stone event and for those with recurrent urolithiasis. The recurrence rate is significantly reduced by targeted treatment (10-15% vs. 50-80%) (39,40).…”
Section: Ammonium Uratementioning
confidence: 99%
“…If the basic diagnostic measures confirm a stone patient's classification as uncomplicated, this metabolic screening need not be carried out. General urinary stone metaphylaxis with regular follow-ups is sufficient (6,36,37,39).…”
Urolithiasis has many causes and can be treated in many different ways. An extensive metabolic work-up is often necessary for secondary prevention. The various treatment options must be considered for their suitability in each individual patient. Robust data are now available on surgical and interventional methods, but there are as yet no high-quality trials of secondary prevention. Further research should concentrate on the etiology and pathogenesis of urolithiasis.
“…A usual Western diet may promote cystine stone formation, as methionine is contained in substantial quantities in meat, sausages, fish, eggs, and dairy products [ 9 ]. Cystine stone patients are therefore advised to maintain a balanced mixed diet with moderate animal protein content [ 9 , 18 ]. A vegetarian diet theoretically may further reduce urinary cystine excretion and increase cystine solubility by increasing urine pH.…”
Despite the importance of dietary management of cystinuria, data on the contribution of diet to urinary risk factors for cystine stone formation are limited. Studies on the physiological effects of diet on urinary cystine and cysteine excretion are lacking. Accordingly, 10 healthy men received three standardized diets for a period of five days each and collected daily 24 h urine. The Western-type diet (WD; 95 g/day protein) corresponded to usual dietary habits, whereas the mixed diet (MD; 65 g/day protein) and lacto-ovo-vegetarian diet (VD; 65 g/day protein) were calculated according to dietary reference intakes. With intake of the VD, urinary cystine and cysteine excretion decreased by 22 and 15%, respectively, compared to the WD, although the differences were not statistically significant. Urine pH was significantly highest on the VD. Regression analysis showed that urinary phosphate was significantly associated with cystine excretion, while urinary sulfate was a predictor of cysteine excretion. Neither urinary cystine nor cysteine excretion was affected by dietary sodium intake. A lacto-ovo-vegetarian diet is particularly suitable for the dietary treatment of cystinuria, since the additional alkali load may reduce the amount of required alkalizing agents.
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