Renal toxicity in patients treated with [Lu]Lu-PSMA-617 was low. There was no (sub)acute grade 3 or 4 nephrotoxicity.

Introduction The implantation of penile nodules under the foreskin is unusual in Western society. This practice is known in Slavic and Asian cultures and occasionally appears in the western world. We review the historical and medical evidence found in world literature to this date. Aim We discuss case reports and other literature on penile nodules and evaluate their medical significance. Main Outcome Measures Literature search for MEDLINE publications and additional references from non-Medline indexed publications concerning the implantation of foreign bodies under the foreskin. Methods Literature search for MEDLINE-indexed papers followed by a manual bibliographic review of cross-references. We extended the search to non-MEDLINE references using an Internet-based search engine. More information was retrieved by contacting different experts. A statistical analysis was applied to the data collected. Results There seems to be a predominance of penile bead implantation in Asian countries. The average age of a patient was 25.47 years. The average number of beads implanted was 2.71. There is a higher risk of becoming a sexually transmitted disease. Conclusions The prevalence of complications seems to be low. The incidence and severity of early or delayed complications are unknown but are probably underreported. Complications associated with this procedure should be known, especially partner complications. These nodules will possibly be encountered more often in western countries.

IntroductionMicroRNAs play an important role in many human malignancies; so far, their expression remains to be studied in upper urinary tract urothelial cancer (UUTUC).Materials and MethodsThe expression of eleven microRNAs (miR-10a, miR-21, miR-96, miR-135, miR-141, miR-182, miR-200b, miR-205, miR-429, miR-520b, miR-1244) formerly shown to be upregulated in urothelial bladder cancer were studied in corresponding normal and cancerous tissue samples of patients undergoing nephroureterectomy for UUTUC. Upregulated microRNAs were then measured in serum samples of patients with UUTUC and patients with non-malignant urological diseases to evaluate their potential as non-invasive biomarkers for UUTUC.ResultsMicroRNA expression allowed differentiation of normal and cancerous tissue: miR-21, miR-96, miR-135, miR-141, miR-182, miR-205, miR-429 and miR-520b were significantly overexpressed. Furthermore, miR-205 was upregulated in poorly differentiated UUTUC. The analysis of circulating RNA in serum demonstrated an increase of miR-141 in patients with UUTUC; receiver operator characteristic analysis demonstrated an area under the curve of 0.726 for miR-141 as a diagnostic biomarker. Furthermore, we observed lower levels of miR-10a and miR-135 in UUTUC patients.ConclusionsMicroRNA expression is altered in UUTUC. The analysis of circulating miR-141 may be useful to identify patients with UUTUC.

Urolithiasis has many causes and can be treated in many different ways. An extensive metabolic work-up is often necessary for secondary prevention. The various treatment options must be considered for their suitability in each individual patient. Robust data are now available on surgical and interventional methods, but there are as yet no high-quality trials of secondary prevention. Further research should concentrate on the etiology and pathogenesis of urolithiasis.