Dietary arginine supplementation enhances the growth performance and immune status of broiler chickens

Xu, Yuanqing; Guo, Yiwei; Shi, Binlin; Yan, Sumei; Guo, Xiaoyu

doi:10.1016/j.livsci.2018.01.001

Cited by 33 publications

(46 citation statements)

References 40 publications

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“…The previous studies found that growth and feed efficiency of chickens fed a diet containing either 1.32% or 1.11% ARG supplement increased to reach plateau levels with increasing the concentration of ARG in protein level of 23% or 17.9% diets (Hurwitz, Sklan, Talpaz, & Plavnik, ). As well as, the BW was significantly decreased in broiler chickens supplemented ARG exceeding 1.35% on day 21 (Xu, Guo, Shi, Yan, & Guo, ). Other research has demonstrated that excess intake of ARG reduced in growth rate of fish fed higher levels of ARG (Ahmed & Khan, ).…”

Section: Discussionmentioning

confidence: 99%

Dietaryl‐arginine supplementation influences growth performance and B‐cell secretion of immunoglobulin in broiler chickens

Tan

et al. 2019

Animal Physiology Nutrition

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Our previous study has shown that high levels of l‐arginine (ARG) have reduced serum and mucosal antibody concentrations. In order to provide a better understanding in the application of ARG supplementation in the poultry industry, the study was conducted to investigate the effect of high levels of ARG on performance and B‐cell secretion of immunoglobulin M (IgM) and IgG development in broiler chickens. A total of 192 1‐day‐old male Arbor Acres Plus broilers were randomly allocated into 4 groups (8 replicates per group, 6 birds per replicate) fed diets containing one of four ARG concentrations (analysed): 9.8, 14.7, 19.1 and 23.4 g/kg respectively. Growth performance was measured based on body weight gain (BWG), feed intake (FI) and feed conversion ratio (FCR). Increasing ARG quadratically increased (p < 0.05) BWG and FI with reaching plateau at 14.7 g/kg, while linearly decreased (p < 0.05) FCR, indicating that maximal performance required ARG no more than 14.7 g/kg in diets. Serum IgG and IgM concentrations were linearly reduced (p < 0.05) with increasing ARG. Chickens fed 19.1 g/kg or 23.4 g/kg ARG had lower (p < 0.05) serum IgG or IgM than chickens fed 9.8 g/kg ARG. As for the mRNA expression of bursal IgG and IgM, they were significantly downregulated with increasing ARG (p < 0.05). Chickens on ARG (>19.1 g/kg) had a lower (p < 0.05) IgG and IgM mRNA expression than chickens fed 9.8 g/kg. Activator of transcription 3 (STAT3) mRNA expression was linearly reduced with increasing ARG (p < 0.05), the transcriptional repressor B‐cell lymphoma 6 (BCL6) mRNA expression was quadratically (p < 0.05) responded, and these cytokines had the lowest expression at 19.1 g/kg. ARG supplementation (>14.7 g/kg) did not significantly improve the growth performance, while it may have a potential negative regulatory effect on B‐cell‐mediated humoral immunity in chickens associated with suppression of the STAT3 expression associated with the JAK/STAT3 pathway.

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Section: Discussionmentioning

confidence: 99%

Dietaryl‐arginine supplementation influences growth performance and B‐cell secretion of immunoglobulin in broiler chickens

Tan

et al. 2019

Animal Physiology Nutrition

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“…2-Polyamines, which are synthesized from arginine by ornithine decarboxylase, increase lymphocyte proliferation (Khajali & Wideman, 2010). 3-Arginine increases serum IGF-I concentration, which further can improve immune cell proliferation (Ebrahimi et al, 2017;Xu et al, 2018). However, it seems that in ovo injection of arginine in the present study did not have a prolonged effect on the immune system of broiler chickens.…”

Section: Discussionmentioning

confidence: 60%

“…Tangara et al (2010) reported higher body weight of ducks at 0 and 7 days post-hatch with in ovo injection of 1.2 ml solution of 0.11% arginine. Moreover, feeding high levels of arginine during the rearing period increased daily weight gain and feed conversion ratio (Ebrahimi et al, 2014;Xu et al, 2018). Moreover, feeding high levels of arginine during the rearing period increased daily weight gain and feed conversion ratio (Ebrahimi et al, 2014;Xu et al, 2018).…”

Section: Discussionmentioning

confidence: 98%

“…It seems that improving effect of in ovo injection of arginine on feed conversion ratio may be mediated through the stimulatory role of arginine on insulin, GH and IGF-I secretion, as well as the biosynthesis of polyamines and nitric oxide; so, arginine increases protein synthesis, but decreases protein degradation through the mentioned mechanisms (Jahanian, 2009;Khajali & Wideman, 2010;Xu et al, 2018). It was indicated that in ovo injection of arginine (0.06 ml of 1% arginine solution) increased serum inducible nitric oxide synthase (iNOS) activity and nitric oxide (NO) concentration (Gao et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…NO is important in cardiovascular tone and immune system (Jahanian, 2009). Activated macrophages also produce NO to induce cell cytotoxicity (Xu et al, 2018). 2-Polyamines, which are synthesized from arginine by ornithine decarboxylase, increase lymphocyte proliferation (Khajali & Wideman, 2010).…”

Section: Discussionmentioning

confidence: 99%

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The impact of in ovo injection of l‐arginine on hatchability, immune system and caecum microflora of broiler chickens

Omidi

Ebrahimi

Janmohammadi

et al. 2019

Animal Physiology Nutrition

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The present article was conducted to evaluate the effect of in ovo injection of arginine on hatchability, immune system and caecum microflora of broiler chickens. For this reason, 300 fertile eggs were used in a completely randomized design with three experimental treatments. The experimental groups included: 1%–0.5% l‐arginine (100 eggs), 2%–1% l‐arginine (100 eggs), 3‐ control [included both sham control (injection of distilled water; 50 eggs) and control (no injection; 50 eggs)], which were injected on d 14 of incubation. After hatching, chicks of each experimental group (0.5% l‐arginine, 1% l‐arginine, and control groups) were randomly divided into four equal groups (as replicates) and reared for 30 days. Weight and feeding of chickens were recorded. Next, blood samples of chickens were collected on day 30 to evaluate antibody titre. Also, chickens were slaughtered on 24 and 30 days of the experiment to evaluate immune system organs and caecum microflora. Based on the results, in ovo injection of l‐arginine had no significant effect on hatchability, body weight, antibody titre, spleen, bursa of Fabricius and thymus weight (p > .05). On the other hand, treatments significantly affected feed intake and feed conversion ratio (p < .05). As a novel finding, in ovo injection of l‐arginine increased caecal Lactobacillus (p < .01), while decreasing Coliform and Escherichia Coli bacteria (p < .01). However, treatments did not influence caecal Enterococcus (p > .05). The overall results indicated that in ovo injection of 0.5% l‐arginine had a better improving effect on caecal microflora and then considered as a recommended level of the present experiment.

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Conductometric sensor with calixarene-based chemosensitive element for the arginine detection

et al. 2018

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Dietary arginine supplementation enhances the growth performance and immune status of broiler chickens

Cited by 33 publications

References 40 publications

Dietaryl‐arginine supplementation influences growth performance and B‐cell secretion of immunoglobulin in broiler chickens

Dietaryl‐arginine supplementation influences growth performance and B‐cell secretion of immunoglobulin in broiler chickens

The impact of in ovo injection of l‐arginine on hatchability, immune system and caecum microflora of broiler chickens

Conductometric sensor with calixarene-based chemosensitive element for the arginine detection

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