Dietary antioxidants, non-enzymatic antioxidant capacity and the risk of osteoarthritis in the Swedish National March Cohort

Veen, L. van; Hantikainen, Essi; Bellocco, Rino; Ye, Weimin; Serafini, Mauro; Ponzano, Marta; Grotta, Alessandra; Lagerros, Ylva Trolle

doi:10.1007/s00394-020-02239-8

Cited by 14 publications

(16 citation statements)

References 42 publications

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“…While many studies in animal models and humans generally point to vitamin C supplementation as an efficacious treatment in the prevention of OA, other studies have concluded that excess vitamin C intake may lead to detrimental effects within the body, including increased inflammation and even increased progression of OA. 40,41,43,44,46,50,51,[53][54][55]60 The second is that there does seem to be a general consensus around an optimal dosage for the substances to have a maximal effect. 44,46 Based on our and other published studies, we hypothesize that several important factors have not fully been considered in data collection and analysis, possibly resulting in the discrepancies seen in several of the data sets.…”

Section: Discussion and Suggestions For Future Researchmentioning

confidence: 99%

“…51 While the multiple studies mentioned above have provided data illustrating vitamin C's chondroprotective ability, several other studies published in the literature have reached the opposite conclusion. 53,55,60 No association between vitamin C intake and risk of developing OA was noted in the large prospective cohort study conducted by Veen et al in 2020. 60 Furthermore, Chaganti et al performed a nested case-control study that examined the correlation between knee OA with circulating serum vitamin C and E levels.…”

Section: Vitamin C Supplementation In Osteoarthritic Patientsmentioning

confidence: 99%

“…53,55,60 No association between vitamin C intake and risk of developing OA was noted in the large prospective cohort study conducted by Veen et al in 2020. 60 Furthermore, Chaganti et al performed a nested case-control study that examined the correlation between knee OA with circulating serum vitamin C and E levels. Participants were divided into tertiles based upon serum vitamin C levels through blood assays.…”

Section: Vitamin C Supplementation In Osteoarthritic Patientsmentioning

confidence: 99%

“…While many studies in animal models and humans generally point to vitamin C supplementation as an efficacious treatment in the prevention of OA, other studies have concluded that excess vitamin C intake may lead to detrimental effects within the body, including increased inflammation and even increased progression of OA. 40 , 41 , 43 , 44 , 46 , 50 , 51 , 53 – 55 , 60 The second is that there does seem to be a general consensus around an optimal dosage for the substances to have a maximal effect. 44 , 46 …”

Section: Human Clinical Studiesmentioning

confidence: 99%

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Vitamin C supplementation for the treatment of osteoarthritis: perspectives on the past, present, and future

Dunlap

Patterson

Kumar

et al. 2021

Therapeutic Advances in Chronic Disease

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According to the US Centers for Disease Control and Prevention (CDC), an estimated 14% of adults in the United States have either been diagnosed with osteoarthritis (OA) or have symptoms suggestive of the disease. The CDC also points out that the incidence of OA has been gradually increasing over the past 30 years. What is more worrisome is that this trend is going to accelerate due to the aging demographics of the United States and the increasing prevalence of obesity seen in the country. The need for better preventive treatments and efficacious therapeutics are direly needed to combat this public health crisis. Among the possible treatments being hypothesized, antioxidant supplementation has become one of the most widely studied over the past decade due to its ability to attenuate reactive oxygen species (ROS) formation within chondrocytes, a critical step in the pathogenesis of this disease. Vitamin C has emerged as among the most promising of the antioxidant group, with many animal and human studies having been conducted in recent years. Although many of the studies have shown encouraging results in terms of preventing OA, others have reached opposite conclusions, thus making the data controversial. However, after reviewing several of these studies, we hypothesize that certain parameters may not have been properly considered during data collection. In the end, more randomized placebo-controlled trials in humans are desperately needed in order to fully understand whether vitamin C therapy is efficacious in treating and/or preventing OA.

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Section: Discussion and Suggestions For Future Researchmentioning

confidence: 99%

Section: Vitamin C Supplementation In Osteoarthritic Patientsmentioning

confidence: 99%

Section: Vitamin C Supplementation In Osteoarthritic Patientsmentioning

confidence: 99%

“…While many studies in animal models and humans generally point to vitamin C supplementation as an efficacious treatment in the prevention of OA, other studies have concluded that excess vitamin C intake may lead to detrimental effects within the body, including increased inflammation and even increased progression of OA. 40 , 41 , 43 , 44 , 46 , 50 , 51 , 53 – 55 , 60 The second is that there does seem to be a general consensus around an optimal dosage for the substances to have a maximal effect. 44 , 46 …”

Section: Human Clinical Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Vitamin C supplementation for the treatment of osteoarthritis: perspectives on the past, present, and future

Dunlap

Patterson

Kumar

et al. 2021

Therapeutic Advances in Chronic Disease

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“…A study with 35 osteoarthritis patients showed a negative association between serum vitamin E levels and osteoarthritis pain scores [14]. The Swedish National March Cohort study found that the risk of osteoarthritis increased with higher dietary vitamin E intake level [15]. A cross-sectional study conducted in Changsha City, Hunan, China, found no significant association between dietary vitamin E and the prevalence of osteoarthritis [16].…”

Section: Introductionmentioning

confidence: 99%

Serum Vitamin E is Associated with Osteoarthritis among Korean Older Adults

Park¹,

Kim²,

Hana³

et al. 2022

Cent. Asian j. Med. Sci.

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Objectives:We aimed to examine the cross-sectional association between serum vitamin E level and osteoarthritis in Korean older adults. Methods: Data from the Korea National Health and Nutrition Examination Survey 2016 -2018 were used. Overall, 978 participants aged ≥ 65 years were included in the study. Demographic, lifestyle, and health data were obtained through interviews or self-reported questionnaires. Patients with osteoarthritis were defined if they had responded "yes" to any of these three questions related to diagnosis, current condition, and treatment. Multivariate logistic regression analysis was performed to assess the association between serum vitamin E level and osteoarthritis. Results: After multivariate adjustment, a higher level of vitamin E was found to be associated with a higher prevalence of osteoarthritis (Odds ratio: 2.27, 95 % Confidence Interval: 1.19 -4.34, p for trend = 0.037). Conclusion: A higher level of serum vitamin E was associated with increased osteoarthritis prevalence in older Koreans. Further prospective or clinical studies are needed to verify the causality.

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A standardized nutraceutical supplement contributes to pain relief, improves quality of life and regulates inflammation in knee osteoarthritis patients; A randomized clinical trial

Valsamidou,

Amerikanou,

Tzavara

et al. 2023

Heliyon

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Dietary antioxidants, non-enzymatic antioxidant capacity and the risk of osteoarthritis in the Swedish National March Cohort

Cited by 14 publications

References 42 publications

Vitamin C supplementation for the treatment of osteoarthritis: perspectives on the past, present, and future

Vitamin C supplementation for the treatment of osteoarthritis: perspectives on the past, present, and future

Serum Vitamin E is Associated with Osteoarthritis among Korean Older Adults

A standardized nutraceutical supplement contributes to pain relief, improves quality of life and regulates inflammation in knee osteoarthritis patients; A randomized clinical trial

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