A standardized nutraceutical supplement contributes to pain relief, improves quality of life and regulates inflammation in knee osteoarthritis patients; A randomized clinical trial

Valsamidou, Evdokia; Amerikanou, Charalampia; Tzavara, Chara; Skarpas, George; Mariolis-Sapsakos, Theodoros D.; Zoumpoulakis, Panagiotis; Kaliora, Andriana C.

doi:10.1016/j.heliyon.2023.e20143

Cited by 2 publications

(1 citation statement)

References 58 publications

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“…Larger studies with longer follow-ups are needed to reduce the existing uncertainties. Since capsaicin has mainly pain-relieving property, and the treatment of OA often requires an anti-inflammatory agent (Maqbool et al, 2021), a combination of capsaicin with other phytopharmaceuticals such as curcumin or resveratrol might be worth investigating (Buhrmann et al, 2021;Csaki et al, 2009;Valsamidou et al, 2023). Cost-effectiveness of topical capsaicin compared with, for example, NSAIDs also remains to the determined.…”

Section: Implications For Researchmentioning

confidence: 99%

Efficacy and safety of topical capsaicin in the treatment of osteoarthritis pain: A systematic review and meta‐analysis

Tshering,

Posadzki,

Kongkaew

2024

Phytotherapy Research

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Osteoarthritis (OA) affects hundreds of millions of people worldwide. The objective was to critically appraise the efficacy and safety of topical capsaicin in reducing pain in OA. MEDLINE (PubMed) and Embase (Ebsco) were searched from inceptions until February 2023. The eligibility criteria included randomized controlled trials (RCTs), evaluating topical capsaicin in OA patients. Standard Cochrane methods were used to extract data and to appraise eligible studies. Eight double‐blind RCTs involving 498 patients were included. Five trials (62.5%) were at an overall low risk of bias, and three (37.5%) were at a high risk of bias. Meta‐analysis showed that, in various OA patients, compared with placebo, topical capsaicin (0.0125%–5%) may reduce pain severity measured with visual analog scale (standardized mean difference = −0.84, 95% confidence intervals [CIs] = −1.48 to −0.19, p = 0.01; eight studies). However, topical capsaicin may increase burning sensation at the application site (risk ratio = 5.56, 95% CI = 1.75–17.69, p = 0.004, numbers needed to harm = 3; five studies) when compared with placebo. Limitations include short study durations, small sample sizes, high heterogeneity, and overall low‐to‐very‐low certainty of the evidence. Topical capsaicin may reduce OA pain at follow‐ups of up to 3 months. Larger trials, potentially evaluating capsaicin in combination with phytopharmaceuticals having anti‐inflammatory effects, with longer follow‐ups might be needed to reduce the existing uncertainties. Topical capsaicin might be recommended for short‐term management of pain in OA patients intolerant to nonsteroidal anti‐inflammatory drugs.

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Section: Implications For Researchmentioning

confidence: 99%

Efficacy and safety of topical capsaicin in the treatment of osteoarthritis pain: A systematic review and meta‐analysis

Tshering,

Posadzki,

Kongkaew

2024

Phytotherapy Research

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Exploring the In Vitro Protective Effects of Green-Lipped Mussel (GLM) Oil Extract against Biomarkers of Glucose Metabolism and Inflammation in Chondrocyte Cells

Lessa,

Ebrahimi,

Guan

et al. 2023

Nutraceuticals

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Chondrocyte behavior is critical in osteoarthritis (OA) progression and cartilage deterioration. Recent studies have shown that green-lipped mussel (GLM) oil extracts obtained through solvent extraction can regulate cytokine secretion in cell lines, potentially reducing inflammation and immune cell activation. This study investigates the effects of these extracts on human chondrocyte cell lines to understand their impact on osteoarthritis development. Chondrocyte cultures exposed to osteoarthritis-related inflammatory factors were treated with various concentrations of GLM oil. The results revealed that mussel oils, particularly a commercial mussel powder extract (SOLV.COM), enhance glucose uptake and protect chondrocyte cells. SOLV.COM effectively manages the release of inflammatory markers like interleukin-6 (IL-6) and matrix metalloproteinases-3 (MMP-3), showing increased deoxyglucose uptake. This study highlights the significant influence of extract choice on managing interleukin-6 (IL-6) secretion and cellular activation pathways, demonstrating the potential of SOLV.COM in managing osteoarthritis by controlling reactive oxygen production, regulating glucose metabolism, and inflammatory markers.

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A standardized nutraceutical supplement contributes to pain relief, improves quality of life and regulates inflammation in knee osteoarthritis patients; A randomized clinical trial

Cited by 2 publications

References 58 publications

Efficacy and safety of topical capsaicin in the treatment of osteoarthritis pain: A systematic review and meta‐analysis

Efficacy and safety of topical capsaicin in the treatment of osteoarthritis pain: A systematic review and meta‐analysis

Exploring the In Vitro Protective Effects of Green-Lipped Mussel (GLM) Oil Extract against Biomarkers of Glucose Metabolism and Inflammation in Chondrocyte Cells

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