Dietary antioxidants and behavioral enrichment enhance neutrophil phagocytosis in geriatric Beagles

Hall, Jean A.; Picton, Rebecca A.; Finneran, Phyllis S.; Bird, Karyn E.; Skinner, Monica M.; Jewell, Dennis E.; Zicker, Steven C.

doi:10.1016/j.vetimm.2006.03.019

Cited by 15 publications

(14 citation statements)

References 36 publications

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“…Thus, it is not surprising that a deficit of plasma antioxidants should impair the rapid, effective elimination of N. meningitidis from the nasopharynx. In line with our observations, other authors [13,14], have demonstrated in animal models an increase of the phagocytic activity of leukocytes associated with a diet enriched in antioxidants. A positive association between irritants, such as tobacco smoke or repeated pharyngeal infections, and asymptomatic carriage of N. meningitidis has also been reported [15], but the reasons for this are unclear, but doubtless involve the effectiveness of mucociliary clearance mechanisms and the phagocytic capacity of polymorphonuclear cells or increase of oxidative local stress.…”

supporting

confidence: 93%

Total antioxidant capacity of plasma in asymptomatic carrier state ofNeisseria meningitidis

et al. 2006

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Reduction of the antioxidant capacity of plasma has been linked with the impairment of an effective immune response and so we hypothesized that the carriage rate of Neisseria meningitidis in asymptomatic subjects might correlate with the levels of antioxidants in plasma. To this end we took pharyngeal swabs from 339 children in Marquesado Basic Health Zone, Granada, Spain and in addition determined the total antioxidant capacity (TAC) in plasma samples from these subjects. The overall prevalence of N. meningitidis carriage was 5.9% (mean age 7.1 years) with rates of 10.3% in children aged 3 < or =years, 3.9% between 4 and 7 years and 2.4% in older subjects. Plasma TAC for the < or =3-year-olds was 0.13 for carriers and 1.10 for non-carrier controls (P=0.04), 0.13 for carriers aged 4-7 years (controls 0.63) and 0.28 for carriers aged >7 years (controls 0.52). We analysed the association between TAC in plasma (<0.37 - 2 S.D.) and the carrier state of N. meningitidis. In the carrier state, the odds ratio for this association (TAC in plasma <0.25) was 8.44 (95% CI 1.5-48.9). These findings may suggest a reduced immune response in the host favourable to nasopharyngeal persistence of meningococci.

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supporting

confidence: 93%

Total antioxidant capacity of plasma in asymptomatic carrier state ofNeisseria meningitidis

et al. 2006

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“…Nutrition can aid in aging through changing the mRNA and immune system functions and may have a direct effect on influencing kidney health. It has been shown that dietary antioxidants, coupled with behavioral enrichment, enhance immune function as shown by neutrophil phagocytosis in older beagles [65]. In that intervention the dietary ingredients included were a milieu of antioxidants (Vitamins E, C, and alpha lipoic acid), combined with flavonoids and carotenoids from vegetables, as well as the mitochondrial cofactor L-carnitine.…”

Section: Immune Systemmentioning

confidence: 99%

The Benefit of Anti-Inflammatory and Renal-Protective Dietary Ingredients on the Biological Processes of Aging in the Kidney

Panickar

Jewell

2018

Biology

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One of the significant organ systems which decline in aging is the kidney. While the causes of age-associated decline in renal function are likely multifactorial, oxidative stress and inflammation are hypothesized to play important roles in the structural and functional changes of the kidney. During aging there is a general decline in the glomerular filtration rate (GFR), a primary measurement used to assess kidney function. Inflammation and oxidative stress have been hypothesized to have a significant detrimental effect on renal function in aging and this may be attenuated by renal protective dietary ingredients. These dietary ingredients may affect renal function directly or through a microbiome-mediated secondary product. Likewise, structural changes including renal tubular atrophy, interstitial fibrosis, and glomerulosclerosis have all been described in aging. Such detrimental changes may benefit from dietary ingredients that may delay or attenuate the occurrence of such changes. This review will describe the physiology and pathophysiology of aging in renal function with an emphasis on dogs and cats that develop a decline in kidney function naturally. In addition, the varying biomarkers of health and renal dysfunction will be discussed. Finally, we will evaluate the aid in the management of this normal decline through dietary intervention in animal models.

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“…The cell suspension was then immediately analyzed with flow cytometry. 22,23 Monochlorobimane Assay of GSH Monochlorobimane (mBCl) e is a nonfluorescent molecule that easily crosses cell membranes and forms a conjugation product with intracellular GSH. This conjugation product (mBCl-GSH) is fluorescent; therefore, the subsequent increase in fluorescence detected by flow cytometry represents the concentration of intracellular GSH.…”

Section: Neutrophil Phagocytosis Assaymentioning

confidence: 99%

Neutrophil Function in Septic Dogs

Webb¹,

McCord²,

Dow³

2007

Veterinary Internal Medicne

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Background: Leukocytes appear to enter a hypo-inflammatory state in human patients with a severe bacterial infection, whereas, in swine, intra-abdominal sepsis produces an initial increase and subsequent decrease in neutrophil Fc receptormediated phagocytosis.Hypothesis: Impaired neutrophil function (hypo-inflammatory state) develops in dogs with sepsis. Animals: Thirteen adult client-owned dogs that developed clinical signs consistent with sepsis were assessed for evidence of neutrophil dysfunction. These results were compared with those of 12 healthy dogs.Methods: Flow cytometry combined with the appropriate fluorescent markers allowed for quantification of the phagolysosomal oxidative burst after Fc receptor-mediated phagocytosis of immune complexes, neutrophil phagocytosis of opsonized Escherichia coli, and the intracellular concentration of reduced glutathione as a measure of oxidative stress.Results: The phagolysosomal oxidative burst after Fc receptor-mediated phagocytosis was significantly lower in neutrophils from septic dogs (mean fluorescence intensity 6 standard deviation; 118 6 13 and 165 6 27 for septic and control dogs, respectively, p 5 0.001), although the phagocytosis of opsonized E coli was significantly increased (155 6 74 and 77 6 44 for septic and control dogs, respectively, p 5 0.004). Intracellular reduced glutathione was not significantly different in neutrophils from septic and healthy control dogs.Conclusions: An important component of neutrophil function is decreased in septic dogs. The diminished oxidative burst after Fc receptor-mediated phagocytosis in neutrophils from septic dogs could hinder the ability of the innate immune system to clear bacterial infections or it might help protect these patients from the systemic consequences of infection.

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Dietary antioxidants and behavioral enrichment enhance neutrophil phagocytosis in geriatric Beagles

Cited by 15 publications

References 36 publications

Total antioxidant capacity of plasma in asymptomatic carrier state ofNeisseria meningitidis

Total antioxidant capacity of plasma in asymptomatic carrier state ofNeisseria meningitidis

The Benefit of Anti-Inflammatory and Renal-Protective Dietary Ingredients on the Biological Processes of Aging in the Kidney

Neutrophil Function in Septic Dogs

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