Total antioxidant capacity of plasma in asymptomatic carrier state of<i>Neisseria meningitidis</i>

Uberos, J.; Molina-Carballo, Antonio; Galdo-Muñoz, G.; Muñóz-Hoyos, Antonio

doi:10.1017/s0950268806007539

Cited by 13 publications

(6 citation statements)

References 18 publications

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“…Furthermore, at high temperatures, oxidative stress increases, and antioxidants become scarce. Cellular oxidative stress is associated with impairment of host immunity, and immune responsiveness has been found to correlate with levels of antioxidants in plasma in carriers of N meningitidis , particularly in children less than 3 years of age 31, 32…”

Section: Discussionmentioning

confidence: 99%

Airborne dust and high temperatures are risk factors for invasive bacterial disease

Jusot

Neill

Waters

et al. 2017

Journal of Allergy and Clinical Immunology

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BackgroundThe Sahel region of West Africa has the highest bacterial meningitis attack and case fatality rate in the world. The effect of climatic factors on patterns of invasive respiratory bacterial disease is not well documented.ObjectiveWe aimed to assess the link between climatic factors and occurrence of invasive respiratory bacterial disease in a Sahel region of Niger.MethodsWe conducted daily disease surveillance and climatic monitoring over an 8-year period between January 1, 2003, and December 31, 2010, in Niamey, Niger, to determine risk factors for bacterial meningitis and invasive bacterial disease. We investigated the mechanistic effects of these factors on Streptococcus pneumoniae infection in mice.ResultsHigh temperatures and low visibility (resulting from high concentrations of airborne dust) were identified as significant risk factors for bacterial meningitis. Dust inhalation or exposure to high temperatures promoted progression of stable asymptomatic pneumococcal nasopharyngeal carriage to pneumonia and invasive disease. Dust exposure significantly reduced phagocyte-mediated bacterial killing, and exposure to high temperatures increased release of the key pneumococcal toxin pneumolysin through increased bacterial autolysis.ConclusionOur findings show that climatic factors can have a substantial influence on infectious disease patterns, altering density of pneumococcal nasopharyngeal carriage, reducing phagocytic killing, and resulting in increased inflammation and tissue damage and consequent invasiveness. Climatic surveillance should be used to forecast invasive bacterial disease epidemics, and simple control measures to reduce particulate inhalation might reduce the incidence of invasive bacterial disease in regions of the world exposed to high temperatures and increased airborne dust.

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Section: Discussionmentioning

confidence: 99%

Airborne dust and high temperatures are risk factors for invasive bacterial disease

Jusot

Neill

Waters

et al. 2017

Journal of Allergy and Clinical Immunology

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“…Serum TACs (measured by TRAP) of sepsis patients are higher than those of healthy controls and correlated with clinical score [ 21 ]. Plasma TAC (measured by the corcin bleaching method) of asymptomatic carrier of Neisseria meningtidis was lower than those of healthy control children [ 22 ]. Serum TAC (ABTS· + decolorization method) of hypertension patients was lower than controls [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Efficient Assay for Total Antioxidant Capacity in Human Plasma Using a 96-Well Microplate

Kambayashi

Bình

Asakura

et al. 2009

J. Clin. Biochem. Nutr.

115

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SummaryIn the present study, we tried to establish an efficient assay for total antioxidant capacity (TAC) in human plasma using a 96-well microplate. TAC was assessed using lag time by antioxidants against the myoglobin-induced oxidation of 2,2'-azino-di(3-ethylbenzthiazoline-6-sulfonic acid (ABTS) with hydrogen peroxide, and expressed as Trolox equivalent. The linearity of the calibration curve with Trolox was maintained with the Trolox concentration range from 2.5 µM to 25 µM (R 2 = 0.997). The assay was applied to the measurement of TAC in healthy human plasma. Coefficient of variation in intraday assay was 2.4%. Difference was not observed in interday assay. Plasma TAC of men ((569 ± 41) µM Trolox equivalent; n = 6) was higher than that of women ((430 ± 28) µM Trolox equivalent; n = 4). After the vegetable juice was drunk for 1 week, the increase in plasma TAC was observed in almost all the volunteers. In summary, we developed the efficient assay for plasma TAC using a 96-well microplate.

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“…14,15 In this sense, an increase in the TAC of saliva could produce modifications in the adherence of Streptococcus to the den tal plaque and lead to greater cariogenic activity. Several authors 16 have reported greater activity in prooxidant molecules such as nitric oxide (NO) in the saliva of subjects with dental caries.…”

Section: Discussionmentioning

confidence: 99%

Influence of the antioxidant content of saliva on dental caries in an at-risk community

et al. 2008

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• The amount of caries in deciduous teeth is in direct proportion to the observed antioxidant capacity of saliva.• The total antioxidant capacity of saliva is greater among children that have caries.• The presencce of caries in deciduous teeth is associated with caries in permanent teeth. I N B R I E F RESEARCHObjective This study aims to evaluate the relationship between the total antioxidant capacity of saliva and the presence of dental caries in deciduous and permanent teeth, in a group of Saharan children. Methods The dental examination was carried out in accordance with the recommendations of the World Health Organization (WHO). The total antioxidant capacity of the saliva was determined by colorimetry. Results The total antioxidant capacity (TAC) of the saliva of patients with caries in deciduous teeth was 2.89 1/IC50 greater than among those without. We observed a statistically signifi cant linear regression between the number of deciduous teeth affected by caries and the total antioxidant capacity of the saliva: y = 0.24 + 0.53 × TAC saliva (t = 2.93; p = 0.004) (95% CI of b: 0.018-0.088). Conclusions Our results show that the amount of caries in deciduous teeth is in direct proportion to the observed TAC of saliva, and that the presence of caries in deciduous teeth is associated with caries in permanent teeth.

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Total antioxidant capacity of plasma in asymptomatic carrier state ofNeisseria meningitidis

Cited by 13 publications

References 18 publications

Airborne dust and high temperatures are risk factors for invasive bacterial disease

Airborne dust and high temperatures are risk factors for invasive bacterial disease

Efficient Assay for Total Antioxidant Capacity in Human Plasma Using a 96-Well Microplate

Influence of the antioxidant content of saliva on dental caries in an at-risk community

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