Dietary antioxidant capacity and concentration of adiponectin in apparently healthy adults: the ATTICA study

Abstract

Background/Objectives: This study aimed at evaluating the relationship of adiponectin concentration with total dietary antioxidant capacity in free-living, apparently healthy adults from the ATTICA study. Subjects/Methods: A random subsample from the ATTICA study, consisting of 310 men (40±11 years) and 222 women (38 ± 12 years), was selected. Adiponectin, along with other inflammatory markers, was measured in fasting participants. Dietary habits were evaluated using a food frequency questionnaire and the dietary antioxidant capacity was based on published values of Italian foods measured by three different assays: ferric-reducing antioxidant power (FRAP), total radical-trapping antioxidant parameters (TRAP) and trolox-equivalent antioxidant capacity (TEAC). Results: Positive associations were observed between dietary antioxidant capacity and adiponectin concentration, as assessed with FRAP (b±s.e. ¼ 0.012±0.005, P ¼ 0.018 per 1 mmol Fe (II)/day), TRAP (b±s.e. ¼ 0.030±0.013, P ¼ 0.017 per 1 mmol trolox equivalent/day) and TEAC (b ± s.e. ¼ 0.025 ± 0.012, P ¼ 0.042, per 1 mmol trolox equivalent/day) in multiadjusted analysis. Moreover, a negative relation of dietary antioxidant indices with inflammatory markers was revealed. Conclusions: Diets with high antioxidant capacity are related to increased adiponectin levels. An adiponectin-mediated route through which antioxidant-rich foods exert beneficial effects against inflammation and cardiovascular diseases can be thus hypothesized.

Circulating Lp-PLA2 activity correlates with oxidative stress and cytokines in overweight/obese postmenopausal women not using hormone replacement therapy

“…Indeed, Lp-PLA 2 is positively associated with an increased ischemic stroke incidence among hormone replacement therapy (HRT) nonusers in postmenopausal women, in a fashion that is independent of traditional cardiovascular risk factors (Hatoum et al 2010;Detopoulou et al 2009;Koenig et al 2004;Persson et al 2007;Iribarren et al 2005;Ballantyne et al 2005;Yang et al 2006;Khuseyinova et al 2004;Wassertheil-Smoller et al 2008). However, others have failed to observe a correlation between Lp-PLA 2 activity and inflammation.…”

“…Many studies have associated lipoprotein-associated phospholipase A 2 (Lp-PLA 2 ) with circulating triglyceride, LDL cholesterol, and HDL cholesterol levels, body mass index (BMI), age, sex, postmenopausal hormone use, and smoking (Oei et al 2005;Brilakis et al 2005;Hatoum et al 2010;Detopoulou et al 2009;Koenig et al 2004;Persson et al 2007;Iribarren et al 2005;Ballantyne et al 2005;Yang et al 2006;Khuseyinova et al 2004). Lp-PLA 2 catalyzes oxidized LDL (ox-LDL) hydrolysis, w h i c h p r o d u c e s i n f l a m m a t o r y m e d i a t o r s , lysophosphatidylcholine (LysoPC), and oxidized fatty acid (MacPhee et al 1999).…”

Total dietary antioxidant capacity and lung function in an Italian population: a favorable role in premenopausal/never smoker women

“…Nutrient data for specific foods were obtained from the food composition database for epidemiological studies in Italy (Salvini et al, 1998) integrated with the TAC values of a number of foods representative of the average Italian diet, such as fruits, vegetables, oils, beverages, spices, dried fruits, sweets, cereals, pulses and nuts (Pellegrini et al, 2003(Pellegrini et al, , 2006. The TAC database has been widely validated in the Italian population (Brighenti et al, 2005;Valtueña et al, 2008;Del Rio et al, 2011) as well in Spanish (Agudo et al, 2007) and Greek populations (Detopoulou et al, 2010;Psaltopoulou et al, 2011).…”

Association of Hypoadiponectinemia with Hypoglutathionemia in NAFLD Subjects with and without Type 2 Diabetes

“…While pioglitazone treatment increases adiponectin levels and is critical to reverse insulin resistance and improve liver histology in NASH patients [49], adiponectin expression was also shown induced by vitamin E via a peroxisome proliferatoractivated receptor gamma-dependent mechanism [50]. Very recently, Detopoulou et al [51] have reported a positive association between diets with high antioxidant capacity and adiponectin levels which emphasize an adiponectin-mediated route through which antioxidant-rich foods are expected to exert beneficial effects. Therefore, in addition to the insulin-sensitizing and anti-inflammatory activity, our study exposes the antioxidant activity of adiponectin.…”