Dietary and familial determinants of 10-year survival among patients with gastric carcinoma

Palli, Domenico; Russo, Antonio; Saieva, Calogero; Salvini, Simonetta; Amorosi, Andrea; Decarli, Adriano

doi:10.1002/1097-0142(20000915)89:6<1205::aid-cncr3>3.0.co;2-5

Cited by 53 publications

(49 citation statements)

References 27 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, alcohol use was significantly associated with worse outcome among patients with stomach cancer in some studies (17,41). These inconsistencies in the literature might be due to the way that the alcohol-drinking behavior is assessed, for example, in only assessing the alcohol-drinking status or the alcohol-consumption amount (17,39,(42)(43)(44). In our study, alcohol consumption was assessed in terms of both alcohol-drinking status and amount.…”

Section: Discussionmentioning

confidence: 70%

See 1 more Smart Citation

Association of Smoking History with Cancer Recurrence and Survival in Stage III–IV Male Gastric Cancer Patients

Han

Kim

Choi

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Background: Smoking and drinking alcohol are major risk factors for cancer development, and we investigated their effects on gastric cancer prognosis following initial resection.Methods: Data from male patients with stage III-IV gastric adenocarcinoma who underwent surgery between 2001 and 2006 were retrospectively reviewed. Patients were followed up until 2011. Kaplan-Meier plots and Cox proportional hazards regressions were applied for survival rates.Results: Among 238 patients, 151 (63.4%) smoked and 146 (61.3%) drank alcohol. Current smokers had an increased risk of cancer recurrence or death from any cause [adjusted HR (aHR), 1.94; 95% confidence interval (CI), 1.18-3.21], cancer recurrence (aHR, 1.89; 95% CI, 1.12-3.21), and overall mortality (aHR, 2.14; 95% CI, 1.23-3.73) compared with never-smokers. Patients with a lifetime cigarette smoking of <40 and !40 pack-years had increased cancer recurrence or death from any cause (aHR, 1.72 and 2.43, respectively; 95% CI, 1.03-2.86 and 1.38-4.30, respectively), cancer recurrence (aHR, 1.63 and 2.61, respectively; 95% CI, 0.95-2.79 and 1.43-4.77, respectively), and overall mortality (aHR, 1.92 and 2.75, respectively; 95% CI, 1.09-3.38 and 1.47-5.12, respectively) compared with never-smokers. However, drinking alcohol was not associated with postsurgery survival.Conclusions: Cigarette-smoking history at the time of diagnosis, but not drinking history, is associated with cancer recurrence and poor survival after surgery in male patients with stage III-IV gastric cancer.Impact: These findings encourage physicians to advise patients with gastric cancer to stop smoking to obtain a general health benefit and likely improvement in the gastric cancer course. Cancer Epidemiol Biomarkers Prev; 22(10); 1805-12. Ó2013 AACR.

show abstract

Section: Discussionmentioning

confidence: 70%

“…Patients in the highest tertile of alcohol intake had a 40% increased risk of all-cause death (HR, 1.41; 95% CI, 1.04-1.91; ref. 17). However, in a Japanese study, current or ever-habitual drinking did not significantly increase mortality HRs (16).…”

Section: Introductionmentioning

confidence: 74%

Association of Smoking History with Cancer Recurrence and Survival in Stage III–IV Male Gastric Cancer Patients

Han

Kim

Choi

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

show abstract

“…However, this hypothesis is not supported by studies evaluating the effect of smoking on the prognosis of gastric cancer, which found no significant differences in survival according to smoking status [76,77]. The visual inspection of the funnel plots and the corresponding statistical tests for asymmetry show that negative studies are underrepresented among those conducted in males.…”

Section: Discussionmentioning

confidence: 88%

Smoking and gastric cancer: systematic review and meta-analysis of cohort studies

Ladeiras-Lopes

Pereira

Nogueira

et al. 2008

Cancer Causes Control

428

284

View full text Add to dashboard Cite

show abstract

“…[39][40][41] One of the latest reports addressing this issue demonstrated a favorable prognosis for patients with a positive family history of GC, whereas others did not. [39][40][41] These controversial results may have been affected by different strategies in selecting the study population and, mainly, by inconsistent definitions and clinical criteria for family history, precluding comparison of trustworthy results. In light of our own findings, molecular variables such as CDH1 alterations may be crucial to better define the survival of patients with family history.…”

Section: Discussionmentioning

confidence: 99%

Somatic Mutations and Deletions of the E-Cadherin Gene Predict Poor Survival of Patients With Gastric Cancer

Corso

Carvalho

Marrelli

et al. 2013

JCO

153

114

View full text Add to dashboard Cite

Purpose The prognosis of gastric cancer (GC) is poor, and the molecular pathogenesis players are vastly unknown. Surgery remains the primary option in GC treatment. The aim of this study was to investigate the impact of somatic CDH1 alterations in prognosis and survival of patients with GC. Patients and Methods A series of patients with sporadic and familial GC (diffuse and intestinal; n = 246) were analyzed for somatic CDH1 mutations, promoter hypermethylation, and loss of heterozygosity (LOH) by polymerase chain reaction sequencing. E-cadherin protein expression was determined by immunohistochemistry. Associations between molecular, clinicopathologic, and survival data were analyzed. Results CDH1 somatic alterations were found in approximately 30% of all patients with GC. Both histologic types of sporadic GC displayed LOH in 7.5%, mutations in 1.7%, and hypermethylation in 18.4% of patients. Primary tumors from hereditary diffuse GC, lacking germline CDH1 alterations, showed exclusively CDH1 promoter hypermethylation in 50% of patients. Familial intestinal GC (FIGC) tumors showed LOH in 9.4% and hypermethylation in 17.0%. CDH1 alterations did not associate with a particular pattern of E-cadherin expression. Importantly, the worst patient survival rate among all GCs analyzed was seen in patients with tumors carrying CDH1 structural alterations, preferentially those belonging to FIGC families. Conclusion CDH1 somatic alterations exist in all clinical settings and histotypes of GC and associate with different survival rates. Their screening at GC diagnosis may predict patient prognosis and is likely to improve management of patients with this disease.

show abstract

Dietary and familial determinants of 10-year survival among patients with gastric carcinoma

Cited by 53 publications

References 27 publications

Association of Smoking History with Cancer Recurrence and Survival in Stage III–IV Male Gastric Cancer Patients

Association of Smoking History with Cancer Recurrence and Survival in Stage III–IV Male Gastric Cancer Patients

Smoking and gastric cancer: systematic review and meta-analysis of cohort studies

Somatic Mutations and Deletions of the E-Cadherin Gene Predict Poor Survival of Patients With Gastric Cancer

Contact Info

Product

Resources

About