Dietary amino acids and incidence of hypertension: A principle component analysis approach

Teymoori, Farshad; Asghari, Golaleh; Mirmiran, Parvin; Azizi, Fereidoun

doi:10.1038/s41598-017-17047-0

Cited by 45 publications

(41 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…www.nature.com/scientificreports www.nature.com/scientificreports/ signature found in women could be at least partially linked to this difference in BMI. Elevated concentrations of branched amino acids are known to promote endothelial dysfunction, inflammation, and oxidative stress 57 and may promote hypertension 58 . Insulin resistance could contribute to hypertension through altered NO release 59 .…”

Section: Discussionmentioning

confidence: 99%

Sexual Dimorphism of Metabolomic Profile in Arterial Hypertension

Goïta

Barca

Keïta

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Metabolomic studies have demonstrated the existence of biological signatures in blood of patients with arterial hypertension, but no study has hitherto reported the sexual dimorphism of these signatures. We compared the plasma metabolomic profiles of 28 individuals (13 women and 15 men) with essential arterial hypertension with those of a healthy control group (18 women and 18 men), using targeted metabolomics. Among the 188 metabolites explored, 152 were accurately measured. Supervised OPLS-DA (orthogonal partial least squares-discriminant analysis) showed good predictive performance for hypertension in both sexes (Q 2 cum = 0.59 in women and 0.60 in men) with low risk of overfitting (pvalue-CV ANOVA = 0.004 in women and men). Seventy-five and 65 discriminant metabolites with a VIP (variable importance for the projection) greater than 1 were evidenced in women and men, respectively. Both sexes showed a considerable increase in phosphatidylcholines, a decrease in C16:0 with an increase in C28:1 lysophosphatidylcholines, an increase in sphingomyelins, as well as an increase of symmetric dimethylarginine (SDMA), acetyl-ornithine and hydroxyproline. Twenty-nine metabolites, involved in phospholipidic and cardiac remodeling, arginine/nitric oxide pathway and antihypertensive and insulin resistance mechanisms, discriminated the metabolic sexual dimorphism of hypertension. Our results highlight the importance of sexual dimorphism in arterial hypertension.

show abstract

Section: Discussionmentioning

confidence: 99%

Sexual Dimorphism of Metabolomic Profile in Arterial Hypertension

Goïta

Barca

Keïta

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Trained interviewers collected information on age, sex, medical history, medication use, and smoking habits using pretested questionnaires. The participant's weight, height, waist circumference (WC), were measured based on standard protocols as previously described [21]. Body mass index (BMI) was calculated as weight (Kg) divided by height squared (m 2 ).…”

Section: Clinical and Biological Measurementsmentioning

confidence: 99%

“…Blood samples were centrifuged within 30 to 45 min of collection. Details of the biochemical analyses and measurements including triglycerides (TGs), Serum total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C), fasting blood sugar (FBS), and blood pressure (BP) have been reported previously [18,20,21].…”

Section: Clinical and Biological Measurementsmentioning

confidence: 99%

“…Furthermore, mechanisms which regulate serum glucose and BP are highly sensitive, and maintain their levels in a normal range [22], in comparison to weight which is easily influenced by dietary energy and fat intakes. Although the association of single nutrient such as sodium, calcium, potassium, magnesium [23], and amino acids [21,24] with BP, and simple sugars, fructose, etc. [25] with FBS has been proved previously; but when the association of whole nutrients with FBS and BP were evaluated, the interaction of useful, inactive and potentially harmful nutrients is inevitable and their effects may be neutralized by each other.…”

Section: Nutrient Patterns and Prospective Changes In Bp And Fbsmentioning

confidence: 99%

See 1 more Smart Citation

Nutrient patterns and cardiometabolic risk factors among Iranian adults: Tehran lipid and glucose study

et al. 2020

Self Cite

View full text Add to dashboard Cite

Background: The present study aimed to assess the relation between nutrient patterns and changes in adult anthropometric and cardiometabolic factors. Methods: This study was conducted on 1637 adults participating in the Tehran Lipid and Glucose Study (2005-2008), who were free of cardiovascular diseases and cancer and had completed dietary data. They were followed to the next survey (2008-2011). Dietary intakes were collected and nutrient patterns were obtained. Three year changes in anthropometric and cardiometabolic factors were measured. Results: Five nutrient patterns were extracted. The first pattern was characterized by "plant protein, thiamine, niacin, and minerals including phosphorus, zinc, copper, magnesium, manganese, and selenium". Animal protein, lactose, vitamin D, riboflavine, pantothenic acid, vitamin B12, calcium, phosphorus, and zinc" were loaded in the second pattern. The third and fourth patterns were characterized by "vitamin K, fiber, calcium, iron, manganese, and potassium", and "high correlation with starch, thiamine and folate, and negative correlation with mono and poly unsaturated fatty acids and vitamin E", respectively. The fifth pattern was high in Fructose, vitamins A, C, pyridoxine, and potassium. There was no association between nutrient patterns and 3-year changes in blood pressure and fasting blood glucose; whereas, per each quartile increment of the fifth pattern adjusted for potential confounders, triglyceride change was decreased [β = − 3.66, 95% CI (− 6.57, − 0.57); P for trend = 0.014]. Conclusion: Present study indicates that nutrient patterns may have an association with cardiometabolic factors, particularly a pattern rich in fructose, vitamins A, C, pyridoxine, and potassium which decreases triglyceride level.

show abstract

“…With the acceleration of industrialization, urbanization, and aging, the epidemic of chronic diseases has become the leading health threat in China, characterized by “a large number of patients, high medical costs, long course and high demand for services,” as highlighted by international institutions such as the World Bank and World Health Organization (WHO) . Of the cardiovascular diseases, hypertension has the highest incidence, representing a greater fatal risk factor owing to being a chronic noncommunicable disease . At present, there are more than 200 million patients with hypertension in China accounting for 80% of all chronic diseases diagnosed .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a community‐based hypertension self‐management model with general practitioners

Zhang

Liu

Sheng³

et al. 2019

Health Planning & Management

View full text Add to dashboard Cite

Summary Background Preventive interventions of hypertension and health care activities are often performed in the community and at home. Studies have shown that self‐management plays an indispensable role in the management of chronic diseases. This study aimed to explore an innovative community‐based hypertension self‐management model and to evaluate its effects. Methods The study involved qualitative and quantitative research methods. A community‐based hypertension self‐management model was developed using consultation with experts and qualitative interviews. The intervention was executed in the communities of Pudong New Area in Shanghai, China. We enrolled 1080 patients with hypertension in the intervention group and 588 similar patients in the control group. A questionnaire was administered before and after the intervention to collect information on patients' health status, self‐management skills, and disease management abilities. Analyses were conducted to evaluate changes in the health‐related outcomes. Results There was a significant difference in general health and health literacy after the intervention for the intervention patients group (P < .05). Furthermore, the proportion of health literacy was higher in the intervention group than in the control group (71.6% vs 59.6%). The significant differences were demonstrated in the comparison of the disease management ability data between the intervention and control group, especially in drug compliance, physical activity, regulate diet, and smoking. In addition, there is other evidence of the successful applicability and effectiveness of the community‐based hypertension self‐management program in 2007‐2013, such as self‐management teams formation and blood pressure control rate. Conclusions The community‐based self‐management hypertension model, which involved the participation of general practitioners, is suitable for the management of hypertension disease in Pudong of Shanghai and could provide a reference for its large‐scale promotion and application.

show abstract

Dietary amino acids and incidence of hypertension: A principle component analysis approach

Cited by 45 publications

References 34 publications

Sexual Dimorphism of Metabolomic Profile in Arterial Hypertension

Sexual Dimorphism of Metabolomic Profile in Arterial Hypertension

Nutrient patterns and cardiometabolic risk factors among Iranian adults: Tehran lipid and glucose study

Evaluation of a community‐based hypertension self‐management model with general practitioners

Contact Info

Product

Resources

About