2017
DOI: 10.1016/j.foodchem.2017.05.104
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Dietary acrylamide: What happens during digestion

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Cited by 55 publications
(38 citation statements)
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“…In the body, detoxification of ACR will be achieved by enzymatic and nonenzymatic conjugation with GSH, which is the main route for detoxification in humans and experimental animals. Besides, metabolization of ACR via CYP2E1, minor route for detoxification, causes generation of a reactive epoxy compound, glycidamide, directly involved in mutagenic and carcinogenic effects of ACR, and also reactive oxygen species (ROS) (Wie et al, 2015, Sassano et al, 2017.…”
Section: Discussionmentioning
confidence: 99%
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“…In the body, detoxification of ACR will be achieved by enzymatic and nonenzymatic conjugation with GSH, which is the main route for detoxification in humans and experimental animals. Besides, metabolization of ACR via CYP2E1, minor route for detoxification, causes generation of a reactive epoxy compound, glycidamide, directly involved in mutagenic and carcinogenic effects of ACR, and also reactive oxygen species (ROS) (Wie et al, 2015, Sassano et al, 2017.…”
Section: Discussionmentioning
confidence: 99%
“…ACR does not occur naturally in diets but however, can be generated from food components during heat treatment as a result of Maillard reaction condensation of the carbonyl group of reducing sugars with the nucleophilic amino group of the amino acids (especially asparagine and lysine residues) (Lambert et al, 2018). Generation of ACR by this reaction mainly depends on the food cooking and processing conditions, especially temperature (above 120-150 C) (Sassano et al, 2017;Lambert et al, 2018). ACR is a well-known neurotoxic agent in both humans and experimental animals which can show dose-and time-dependent deleterious effects, mainly degeneration, on central and peripheral nervous systems (Kopanska et al, 2018;Lopachin, 2004).…”
Section: Introductionmentioning
confidence: 99%
“…Se requiere una temperatura superior a 120 °C para generar acrilamida; esto ocurre, con frecuencia, en alimentos ricos en carbohidratos sometidos a fritura, asado u horneo. La mayor preocupación sobre la ingesta de acrilamida proviene de los cereales procesados (como galletas, pan o cereales para el desayuno), café y tubérculos fritos (papa y yuca) [39]. En Colombia se ha suscitado un creciente interés por controlar la formación de acrilamidas durante la elaboración de panela, producto típico nacional [40].…”
Section: Reacción De Maillardunclassified
“…Como alternativa a las freidoras convencionales, las freidoras de aire se han introducido recientemente en el país, debido a su capacidad para producir alimentos crujientes más saludables (bajos en grasa). De hecho, un estudio reciente mostró reducciones en la formación de acrilamida de hasta el 90% en las papas fritas deshidratadas con aire, en comparación con la operación convencional con aceite [39].…”
Section: Reacción De Maillardunclassified
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