Dietary accumulation of tetrabromobisphenol A and its effects on the scallop Chlamys farreri

Hu, Fengxiao; Pan, Luqing; Xiu, Meng; Liu, Dong

doi:10.1016/j.cbpc.2014.08.002

Cited by 14 publications

(8 citation statements)

References 71 publications

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“…Significant increased activity of GST may serve as the likely explanation for the fast metabolism and excretion of TBBPA. We also noticed that the changes of GST activity did not depend on the trend of phase I metabolism, supporting the notion that TBBPA, with phenolic hydroxyl groups, could be directly metabolized by conjugative phase II enzyme systems such as GST and UDP-glucoronyl transferases (Pflugmacher, Schröder, and Sandermann 2000;Hu et al 2015) Previous studies suggested that TBBPA might induce oxidative stress in fishes (Ronisz et al 2004;Kling and Förlin 2009) and coontail (Sun, Guo, Yu, Wang, Wu, and Xue 2008a, b) and cause oxidative damage in liver of Carassius auratus (Shi et al 2005). In the present study, SOD activity was significantly induced in both tissues of Chlamys farreri exposed to TBBPA.…”

Section: Discussionsupporting

confidence: 53%

Exposure of Chlamys farreri to tetrabromobisphenol A: accumulation and multibiomarker responses

Pan

Xiu

et al. 2015

Environ Sci Pollut Res

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Tetrabromobisphenol A (TBBPA) is currently the most widely used brominated flame retardant (BFR). To date, the toxic effects of TBBPA remains poorly understood in aquatic organisms, especially in bivalves. The objective of this experiment was to examine bioaccumulation and multibiomarker responses in the scallop Chlamys farreri exposed to TBBPA under laboratory conditions. The results showed that TBBPA was rapidly accumulated in and then eliminated from the gill and digestive gland of the scallops. TBBPA exposure invoked alterations in the detoxification system and induced oxidant stress and biomacromolecule damages in the gill and digestive gland of C. farreri. Additionally, glutathione-S-transferase (GST) activity, lipid peroxidation (LPO) level, cytochrome b5 (Cyt b5) content, and DNA strand break had good correlations with TBBPA accumulation levels in the gill and digestive gland of C. farreri. Summarizing, these results enabled us to hypothesize several toxic mechanisms of TBBPA and select potential biomarkers for TBBPA pollution monitoring.

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Section: Discussionsupporting

confidence: 53%

Exposure of Chlamys farreri to tetrabromobisphenol A: accumulation and multibiomarker responses

Pan

Xiu

et al. 2015

Environ Sci Pollut Res

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“…Our BAFs estimated in the fish species were comparable to those (400-39800) calculated in three fish species from a river in a highly industrialized area in South China (He et al 2013), but were much higher than that (0.62) calculated in fish from English lakes (Harrad et al 2009), and those (0.53-0.84) in healthy scallops from the Yellow Sea, China (Hu et al 2015). The speciesspecific accumulation of TBBP-A and the site-specific environmental TBBP-A concentrations among these studies may account for the observed differences in BAF for TBBP-A.…”

Section: Bioaccumulation Potential and Species-specific Accumulationsupporting

confidence: 68%

“…Conclusively, TBBP-A levels detected in organisms from e-waste sites are at the higher end of the reported concentration ranges, suggesting that e-waste sites are one of the Bworst-case scenarios^of TBBP-A. The elevated TBBP-A concentrations in the aquatic species from the e-waste site is of concern, because TBBP-A has been demonstrated to be toxic to aquatic organisms (Kuiper et al 2007;Hu et al 2015). An understanding of TBBP-A influences on these species, especially the two aquatic invertebrates, deserves further study.…”

Section: Tbbp-a Levelsmentioning

confidence: 97%

“…Such exposure scenarios challenge the risk assessment of TBBP-A conducted by the European Union (European Chemicals Bureau 2008). The high bioaccumulation potentials for TBBP-A in the aquatic invertebrates from the worst-case scenarios is of concern, because TBBP-A has been demonstrated to be toxic to these animals (Sverdrup et al 2006;Hu et al 2015). An advanced understanding of mechanisms responsible for aquatic invertebrates bioaccumulation of TBBP-A is needed.…”

Section: Bioaccumulation Potential and Species-specific Accumulationmentioning

confidence: 99%

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Aquatic bioaccumulation and trophic transfer of tetrabromobisphenol-A flame retardant introduced from a typical e-waste recycling site

Lin

Zhi

et al. 2016

Environ Sci Pollut Res

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A b s t r a c t W h i l e t h e f l a m e r e t a r d a n t c h e m i c a l , tetrabromobisphenol-A (TBBP-A), has been frequently detected in the environment, knowledge regarding its speciesspecific bioaccumulation and trophic transfer is limited, especially in the highly contaminated sites. In this study, the components of an aquatic food web, including two invertebrates, two prey fish, and one predator fish, collected from a natural pond at an electronic waste (e-waste) recycling site in South China were analyzed for TBBP-A, using liquid chromatography-tandem mass spectrometry. The aquatic species had TBBP-A concentrations ranging from 350 to 1970 pg/g wet weight, with higher concentrations in the invertebrates relative to the fish species. Field-determined bioaccumulation factors of TBBP-A in the two aquatic invertebrates were nearly or greater than 5000, suggesting that TBBP-A is highly bioaccumulative in the two species. The lipid-normalized concentrations of TBBP-A in the aquatic species were negatively correlated with the trophic levels determined from stable nitrogen isotope (δ 15 N) (r = −0.82, p = 0.09), indicating that this compound experienced trophic dilution in the current food web.

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“…HPLC-DAD, a practical method for determining polar compounds, has also been proposed as a supplementary method for determining TBBPA/S and their derivatives [21][22][23], such as TBBPA-BDBPE and TBBPA-BAE in soil [9] and biological samples [7,23,24], TBBPA in food [25], water [26] and biological samples [21,22]. But it often suffers from the interfering substances due to its identification mainly depending on the retention time of target compounds [9].…”

Section: Introductionmentioning

confidence: 99%

Thin-layer chromatography coupled with high performance liquid chromatography for determining tetrabromobisphenol A/S and their derivatives in soils

Liu

Shen

Tian

et al. 2017

Journal of Chromatography A

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As brominated flame retardants (BFRs), tetrabromobisphenol A/S (TBBPA/S) and their derivatives have raised wide concerns owing to their widely usage, distributions and adverse effects on human health, thus monitoring these BFRs was urgently needed. In this study, a rapid and cost-effective method based on thin-layer chromatography (TLC) sample pre-treatment coupled with high performance liquid chromatography-diode array detector (HPLC-DAD) (UV=214nm) was developed for determining TBBPA/S and their derivatives in soils, including TBBPA, TBBPA bis(allyl ether) (TBBPA-BAE), TBBPA bis(2,3-dibromopropyl ether) (TBBPA-BDBPE), TBBPS bis(allyl ether) (TBBPS-BAE) and TBBPS bis(2,3-dibromopropyl ether) (TBBPS-BDBPE). The method detection limits (MDLs) and the method quantification limits (MQLs) for these BFRs ranged from 0.023 to 0.087μggdw and 0.076-0.29μggdw, respectively. The recoveries were 41-108% and both RSD of repeatability and intermediate precision were less than 11%. The developed method presented good performance for analyzing natural soil samples collected from BFRs industrial park, suggesting its great application potential for monitoring environmental TBBPA/S and their derivatives.

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Dietary accumulation of tetrabromobisphenol A and its effects on the scallop Chlamys farreri

Cited by 14 publications

References 71 publications

Exposure of Chlamys farreri to tetrabromobisphenol A: accumulation and multibiomarker responses

Exposure of Chlamys farreri to tetrabromobisphenol A: accumulation and multibiomarker responses

Aquatic bioaccumulation and trophic transfer of tetrabromobisphenol-A flame retardant introduced from a typical e-waste recycling site

Thin-layer chromatography coupled with high performance liquid chromatography for determining tetrabromobisphenol A/S and their derivatives in soils

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