2012
DOI: 10.2164/jandrol.111.015578
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Diet, Obesity, and Prostate Health: Are We Missing the Link?

Abstract: Prostate problems, such as benign prostatic hyperplasia, prostatic intra-epithelial neoplasia, prostatitis, and prostate cancer have been recognized as problems largely related to androgens and genetic factors. They affect a large fraction of the elderly population, contributing significantly to morbidity and mortality. Estrogen has also now been recognized as one of the important regulators of prostate growth. Diet, general health, and obesity were disregarded as the causative or complicating factors until ve… Show more

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Cited by 36 publications
(28 citation statements)
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“…Increased mortality and aggressiveness of PCa have been associated with obesity [38]. In 2007, the SNP rs9930506 in the fat mass and obesity-associated (FTO) gene region was associated with BMI and risk of obesity [9].…”
Section: Introductionmentioning
confidence: 99%
“…Increased mortality and aggressiveness of PCa have been associated with obesity [38]. In 2007, the SNP rs9930506 in the fat mass and obesity-associated (FTO) gene region was associated with BMI and risk of obesity [9].…”
Section: Introductionmentioning
confidence: 99%
“…Globally, benign prostatic hyperplasia affects about 210 million males (Vos et al, 2012). Although BPH is predominantly attributed to aging, genetic factors and hormonal disturbances (Nicholson and Ricke, 2011), a possible role of obesity, diet and life style is also under investigation (Tewari et al, 2012;Goluch-Koniuszy et al, 2013). Similarly the significance of chronic inflammation in pathogenesis of BPH has recently emerged (Fibbi et al, 2010) and emphasized by recent publications (Vral et al, 2012;Bostanci et al, 2013;of cancer death (Brawley, 2012a).…”
Section: Introductionmentioning
confidence: 99%
“…A deeper research into the factors that differ significantly across these continents may answer the questions regarding its incidence and causative factors. The foremost risk factors that may underlie these regional/ethnic differences could be endocrine variations, genetic polymorphisms (ZeiglerJohnson et al, 2002) altered hormonal status (Garfinkel, 1986), socioeconomic status (Nomura and Kolonel, 1991) and obesity and diet (Stephen and Brady, 2005;Girling et al, 2007) Diet, disturbed glucose metabolism, and metabolic syndrome are extremely interesting factors for in depth exploration in relation to the risk of prostate cancer (Long et al, 2012;McGrowder et al, 2012;Tewari et al, 2012;Ozbek et al, 2014, Pandeya et al 2014 In an earlier study, we presented that body mass index and waist to hip ratio were significantly higher in prostate cancer in 1 , Singh Rajender 2 *…”
Section: Introductionmentioning
confidence: 99%