Histopathologic Characterization of Prostate Diseases in Madinah, Saudi Arabia

Albasri, Abdulkader M.; El-Siddig, Abeer Abdalla; Hussainy, Akbar Shah; Mahrous, Mervat; Alhosaini, Abdulaziz Abdullah; Alhujaily, Ahmed Safar

doi:10.7314/apjcp.2014.15.10.4175

Cited by 27 publications

(32 citation statements)

References 28 publications

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“…Gleason score of 8 or more was seen in 20.6% of patients in our study, similarly 16.8% in Spanish data. Most common Gleason score was 6 as in the study done in a rural area of North Western Greece (Grivas et al, 2012) while it was reported as 7 in Saudi Arabia (Albasri et al, 2014) and Pakistan (Arshad et al, 2013). We found significant positive correlation between serum PSA level and Gleason score in accordance with the findings of the studies done in a rural area of North Western Greece (Grivas et al 2012) and Saudi Arabia ( (Albasri et al, 2014).…”

Section: Discussionsupporting

confidence: 88%

Prostate Cancer Incidence in Turkey: An Epidemiological Study

Zorlu¹,

Divrik²,

Yörükoğlu³

2014

Asian Pacific Journal of Cancer Prevention

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Background: This study aimed to determine the incidence of prostate cancer in Turkey in a population-based sample, and to determine clinical and pathological characteristics of the cases. Materials and Methods: All newly diagnosed prostate cancer patients were included in this national, multi-centered, prospective and noninterventional epidemiological registry study conducted in 12 cities representing the 12 regions of Turkey from July 2008 to June 2009. The population-based sample comprised 4,150 patients with a recent prostate cancer diagnosis. Results: Age-adjusted prostate cancer incidence rate was 35 cases per 100,000 in Turkey. At the time of diagnosis, median age was 68, median PSA level was 10.0 ng/mL. Digital rectal examination was abnormal in 36.2% of 3,218 tested cases. Most patients had urologic complaints. The main diagnostic method was transrectal ultrasound guided biopsy (87.8%). Gleason score was ≤6 in 49.1%, 7 in 27.8% and >7 in 20.6% of the cases. There was a statistically significant positive correlation between serum PSA level and Gleason score (p=0.000). The majority of patients (54.4%) had clinical stage T1c. Conclusions: This is the first population-based national data of incidence with the histopathological characteristics of prostate cancer in Turkey. Prostate cancer remains an important public health concern in Turkey with continual increase in the incidence and significant burden on healthcare resources.

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Section: Discussionsupporting

confidence: 88%

Prostate Cancer Incidence in Turkey: An Epidemiological Study

Zorlu¹,

Divrik²,

Yörükoğlu³

2014

Asian Pacific Journal of Cancer Prevention

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“…This is presently the norm in Sub-Saharan Africa [21,22]. The peak age incidence is, however, similar to that documented by Albasri et al [23] and Obiorah et al [24].…”

Section: Discussionsupporting

confidence: 80%

Assessment of the value of the different variants of abnormal digital rectal examination finding in predicting carcinoma of the prostate: a preliminary report of a two-center study

Irekpita

Achor²,

Alili

2020

Afr J Urol

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Background: Digital rectal examination is a veritable tool for the clinical diagnosis and screening for carcinoma of the prostate. This study aims to assess the value of the different variables which constitute abnormal digital rectal examination (DRE) findings. Results: Following ethical approval, one hundred and thirty-one men met the inclusion criteria and were enrolled in the study. The peak incidence of abnormal DRE finding was in the 8th decade of life, while the PPV was 66.5%. Of the total, 44 (33.5%) were nodular hyperplasia, 12 (9.2%) were prostate intra-epithelia neoplasia, while 75 (57.3%) were adenocarcinoma. With a positive predictive value (PPV) of 73.3%, a hard nodular feel was the only abnormal DRE finding that independently and significantly predicted the risk of prostatic adenocarcinoma. A suspicious nodule and obliterated median groove had PPV of 23.1% and lobar asymmetry, 0%. There was a statistically significant correlation (P = 0.005) between DRE findings and histology, between PSA and histology (P = 0.000) and between the size of the prostate and PSA value (P = 0.021). The mean size of the prostate was 101.2 g, standard deviation 92.11783, maximum 648 g and minimum 13.6 g. Conclusion: Most of the variants of abnormal DRE findings do not sufficiently predict the risk of adenocarcinoma on their own. They need to be in combination with other DRE findings or a raised PSA to significantly predict adenocarcinoma.

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“…The demographic profile,clinical details, bone scan results of the patient population of our study matches numerous studies conducted in relation to prostatic carcinoma. [6][7][8][9][10][11][12][13][14][15][16][17] The mean pretreatment PSA levels in various studies was different with a wide range.A study by Alpeshpuri et al [18] found a low value, of about 20.33ng/ml while a study by Albasri et al [19] reported serum PSA as high as 363.4ng/ml in CaP.In our study mean PSA level in prostate carcinoma was 128ng/ml. We had one case below the cutoffsPSA value.…”

Section: Discussioncontrasting

confidence: 41%