Diet-microbiome interactions in cancer treatment: Opportunities and challenges for precision nutrition in cancer

Greathouse, K. Leigh; Wyatt, Madhur; Johnson, Abigail; Toy, Eugene P.; Khan, Joetta; Dunn, Kelly E.; Clegg, Deborah J.; Reddy, Sireesha

doi:10.1016/j.neo.2022.100800

Cited by 23 publications

(16 citation statements)

References 107 publications

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“…Malnutrition is common among patients diagnosed with cancer and treatments for cancer can exacerbate poor nutritional status [ 124 ]. Consequently, there is growing interest in understanding how personalised/precision nutrition approaches can be used to improve the resilience and health of cancer patients and to enhance the efficacy of conventional cancer treatments [ 125 ]. In a recent RCT, CRC patients post diagnosis were randomised to 2000 IU/day vitamin D or placebo for 12 months [ 126 ].…”

Section: Translation Of Nutrigenomic Research For Personalised and Pr...mentioning

confidence: 99%

Translation of nutrigenomic research for personalised and precision nutrition for cancer prevention and for cancer survivors

Malcomson

Mathers

2023

Redox Biology

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Section: Translation Of Nutrigenomic Research For Personalised and Pr...mentioning

confidence: 99%

Translation of nutrigenomic research for personalised and precision nutrition for cancer prevention and for cancer survivors

Malcomson

Mathers

2023

Redox Biology

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“…Nonetheless, significant prevention, diagnosis, and treatment advancements are expected to substantial increase survival rates. Many cases of cancer could be prevented by adopting a healthful lifestyle which includes a healthy dietary pattern [1][2][3]. While historically there have been insufficient effective treatments such as radiotherapy, chemotherapy, or local therapies in oncology patients, the therapy paradigm has been revolutionised in the last decade by the introduction of systemic therapies and lately with next-generation targeted therapies [4,5].…”

Section: Health Backgroundmentioning

confidence: 99%

Nutrition and Cancer Care – American and European Context

Keaver

Abreu

2023

Komp Nutr Diet

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The Oncology Care Model (OCM) is a US Centers for Medicare & Medicaid Services (CMS) specialty model implemented in 2016, to provide higher quality, more highly coordinated oncology care at the same or lower costs. Under the OCM, oncology clinics enter into payment arrangements that include financial and performance accountability for patients receiving chemotherapy treatment. In addition, OCM clinics commit to providing enhanced services to Medicare beneficiaries, including care coordination, navigation, and following national treatment guidelines. Nutrition is a component of best-practice cancer care, yet it may not be addressed by OCM providers even though up to 80% of patients with cancer develop malnutrition and poor nutrition has a profound impact on cancer treatment and survivorship. Only about half of US ambulatory oncology settings screen for malnutrition, registered dietitian nutritionists (RDNs) are not routinely employed by oncology clinics, and the medical nutrition therapy they provide is often not reimbursed. Thus, adequate nutrition care in US oncology clinics remains a gap area. Some oncology clinics are addressing this gap through implementation of nutrition-focused quality improvement programs (QIPs) but many are not. What is needed is a change of perspective. This paper outlines how and why quality nutrition care is integral to the OCM and can benefit patient health and provider outcomes.

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“…Clinical studies have also shown alterations in faecal microbiota composition in patients with a range of primary tumour types [32 ▪ ,33]. In addition to contribution to the development of cachexia, the microbiome can impact drug metabolism and response to anticancer treatments [34].…”

Section: Cachexia As a Multisystem Disordermentioning

confidence: 99%

Cancer cachexia – adopting a systems wide approach

Sayers

Skipworth

Laird

2023

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of reviewCancer cachexia results in the death of approximately 2 million people worldwide annually. Despite the impact of this devastating condition, there is limited therapy and no standard of care. Although multiple definitions exist, confusion remains as a true understanding of the biology has not yet been achieved and distinct phases of cachexia have not been examined. Research has mainly focused on weight loss and muscle wasting, but cachexia is increasingly recognized as a multiorgan disorder involving adipose tissue, liver, brain, gut and heart, with systemic inflammation a central unifying feature.Recent findingsIn this review, we will discuss some of the extra-muscular features and multisystem interactions in cachexia, and describe how moving our focus beyond muscle can lead to a greater understanding of the mechanisms and clinical features seen in cachexia.SummaryWe describe the need for robust characterization of patients with cachexia, to allow clinical phenotypes and multisystem mechanisms to be untangled, and to enable the implementation of multimodal treatment strategies.

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Diet-microbiome interactions in cancer treatment: Opportunities and challenges for precision nutrition in cancer

Cited by 23 publications

References 107 publications

Translation of nutrigenomic research for personalised and precision nutrition for cancer prevention and for cancer survivors

Translation of nutrigenomic research for personalised and precision nutrition for cancer prevention and for cancer survivors

Nutrition and Cancer Care – American and European Context

Cancer cachexia – adopting a systems wide approach

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