Translation of nutrigenomic research for personalised and precision nutrition for cancer prevention and for cancer survivors

Malcomson, Fiona C.; Mathers, John C.

doi:10.1016/j.redox.2023.102710

Cited by 7 publications

(1 citation statement)

References 140 publications

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“…The integration of data from genomics (polymorphisms and other structural genetic variants), epigenomics (DNA methylation, histone modifications, telomere length), metagenomics (gut microbiota composition, enterotypes), transcriptomics (gene expression patterns), proteomics (protein expression and modification patterns), and metabolomics (metabolite pattern) have given rise to the identification of some potential molecular targets and active biomarkers involved in many nutritional disorders (including obesity, dyslipidemias, fatty liver, insulin resistance), inflammation, cardiovascular diseases and cancer [ 59 ]. Studies focused on the influence of nutrition on epigenetic mechanisms, such as changes (reversible) in DNA methylation and histone modifications are particularly promising for cancer prevention, since epigenetic abnormalities may occur at a very early stage during neoplastic transformation [ 60 ]. Interestingly, recent reports suggest that miRNAs (small non-coding RNAs which regulate gene and protein expression), are able to mediate the interaction between dietary regimens and a variety of molecular pathways, in both physiological and pathological conditions [ 61 – 64 ].…”

Section: Towards Nutri-omics For Lung Cancermentioning

confidence: 99%

MicroRNAs and the Mediterranean diet: a nutri-omics perspective for lung cancer

Cuttano,

Mazzarelli,

Afanga

et al. 2024

J Transl Med

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Lung cancer is the deadliest cancer type worldwide with ~ 1.8 million deaths per-year. Smoking accounts for ~ 85% of all cases, with a described joint effect with unhealthy diet in lung cancer risk increase. Public health policies to prevent carcinogens exposure, promote smoking cessation and advocacy for healthy nutrition, are therefore highly recommended. Here we have examined the benefits of the Mediterranean Diet (MedDiet) in protecting against some non-communicable diseases including lung cancer, highlighting the epidemiological and biomolecular aspects of MedDiet anti-inflammatory effect and its interaction with smoking habits closely linked to risk of lung cancer. Considering the high incidence and mortality rates of lung cancer, we discussed also about the global impact that a Planeterranean extension of the benefits of MedDiet could have on controlling lung cancer risk. We also debated the impact of personalized nutrition on lung cancer prevention, considering individual heterogeneity in response to diet plans as well as recent advancements on nutri-omics in lung cancer research, with a specific focus on the role of microRNAs (miRNAs) as a promising nutritional molecular hub for lung cancer prevention. We strongly believe that a deep understanding of the molecular link between food components and genetic/epigenetics factors can expand effective intervention strategies.

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