Diet‐induced obesity in young mice: Consequences on the pancreatic intrinsic nervous system control of insulin secretion

Saade, Marie-Béatrice; Cahu, Armelle; Moriez, Raphaël; Neunlist, Michel; Blat, Sophie

doi:10.1002/edm2.95

Cited by 2 publications

(2 citation statements)

References 46 publications

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“…The PINS integrates glucose and other stimulatory signals and is known as a local feedback-integration center [24]. The PINS immediately releases related transmitters to regulate blood glucose homeostasis and meet metabolic needs.…”

Section: Resultsmentioning

confidence: 99%

Neuromechanical Dimorphism of Hypoglycemic Effect of Electroacupuncture

Liu

Wang

et al. 2023

Neuroendocrinology

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Introduction: Eletroacupuncture (EA) has a favorable impact on blood glucose stability. Blood glucose homeostasis is linked to sexual dimorphism. The majority of research has, however, focused on male participants, and sex differences have not been adequately taken into account. Methods: Here, we investigated how EA intervention affected pancreatic metabolic stress and explored if there were any sex-related changes in the maintenance of pancreatic function following intraperitoneal injection of a 10 g/kg glucose solution. Results: The transient receptor potential vanilloid 1 (TRPV1) -calcitonin gene-related peptide (CGRP)-β cell pathway of the male pancreas is vital to maintain glucose metabolism in mice. In contrast, there is a sex bias in TRPV1, which implies that female mice have additional routes for preserving glucose homeostasis. EA is ineffective on Trpv1-/- male mice also revealed that TRPV1 in male mice served as a crucial mediator for the EA control of blood glucose. Meanwhile, the sympathetic marker tyrosine hydroxylase showed higher expression in the male pancreas, while the cholinergic marker choline acetyltransferase is expressed predominantly in female mice. Injecting γ-aminobutyric acid into the paraventricular nucleus of male mice caused a disruption in blood glucose and a lack of response to EA. It verified that male mice had a more pronounced sympathetic innervation of the pancreas than female mice. Conclusion: Our research has demonstrated that the TRPV1 sensory afferent nerve and sympathetic efferent nerve are capable of maintaining glucose homeostasis, exhibiting a distinct sexual dimorphism. Furthermore, this regulation is contingent on the EA effect.

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Section: Resultsmentioning

confidence: 99%

Neuromechanical Dimorphism of Hypoglycemic Effect of Electroacupuncture

Liu

Wang

et al. 2023

Neuroendocrinology

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“…However, the local related neurological changes of the pancreas and the onset mechanism of EA in T2DM are still unclear. Recent work suggests that the pancreatic intrinsic nervous system (PINS) is involved in glucose homeostasis, insulin sensitivity, and pancreatic β cell function, and thus the pathogenesis of diabetes [ 21 ]. It suggested that the intrinsic nervous system is one of the neural mechanisms of acupuncture regulating blood glucose.…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemic Effect of Electroacupuncture at ST25 Through Neural Regulation of the Pancreatic Intrinsic Nervous System

Liu

et al. 2021

Mol Neurobiol

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Electroacupuncture (EA) is considered to have potential antidiabetic effects; however, the role of the pancreatic intrinsic nervous system (PINS) in EA-induced amelioration of type 2 diabetes (T2DM) remains unclear. Therefore, we investigated whether EA at ST25 exerts any beneficial effects on insulin resistance (IR), inflammation severity, and pancreatic β cell function via the PINS in a rat model of a high-fat diet-streptozotocin (HFD/STZ)-induced diabetes. To this end, Sprague Dawley rats were fed with HFD to induce IR, followed by STZ (35 mg/kg, i.p.) injection to establish the T2DM model. After hyperglycemia was confirmed as fasting glucose level > 16.7 mmol/L, the rats were treated with EA (2 mA, 2/15 Hz) for the next 28 days. Model rats showed increased serum glucose, insulin, IR, and TNF-α levels with a concomitant decrease in β cell function. Microscopy examination of the pancreas revealed pathological changes in islets, which reverted to near-normal levels after EA at ST25. EA improved islet cell morphology by increasing islet area and reducing vacuolation. EA at ST25 decreased transient receptor potential vanilloid 1 (TRPV1) and increased substance P (SP) and calcitonin gene-related peptide (CGRP) expression. Subsequently, insulin secretion decreased and impaired pancreatic endocrine function was restored through the TRPV1 channel (SP/CGRP)-insulin circuit. EA increased choline acetyltransferase and neuropeptide Y expression and controlled inflammation. It also enhanced the cocaine and amphetamine-regulated transcript prepropeptide expression and promoted glucagon-like peptide-1 secretion. Additionally, the electrophysiological activity of PINS during acupuncture (2.71 ± 1.72 Hz) was significantly increased compared to the pre-acupuncture frequency (0.32 ± 0.37 Hz, P < 0.05). Thus, our study demonstrated the beneficial effect of EA on β cell dysfunction via the PINS in rat models of HFD-STZ-induced T2DM.

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Diet‐induced obesity in young mice: Consequences on the pancreatic intrinsic nervous system control of insulin secretion

Cited by 2 publications

References 46 publications

Neuromechanical Dimorphism of Hypoglycemic Effect of Electroacupuncture

Neuromechanical Dimorphism of Hypoglycemic Effect of Electroacupuncture

Hypoglycemic Effect of Electroacupuncture at ST25 Through Neural Regulation of the Pancreatic Intrinsic Nervous System

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