Diet impacts triple‐negative breast cancer growth, metastatic potential, chemotherapy responsiveness, and doxorubicin‐mediated cardiac dysfunction

Ramirez, Manuel U.; Clear, Kenysha Y.J.; Cornelius, Zipporah; Bawaneh, Alaa; Feliz-Mosquea, Yismeilin R.; Wilson, Ana; Ruggiero, Alistaire; Cruz‐Diaz, Nildris; Shi, Lihong; Kerr, Bethany A.; Soto-Pantoja, David R.; Cook, Katherine L.

doi:10.14814/phy2.15192

Cited by 3 publications

(1 citation statement)

References 42 publications

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“…Glucose tolerance testing (GTT) was performed on fasted mice as previously described in ref. 67 . Briefly, glucose (2 mg/kg) was administered by intraperitoneal injection and blood glucose was measured 0, 15, 30, 60, and 120 min later using a OneTouch Ultra2 (LifeScan, Inc.) and GenUltimate Test Strips.…”

Section: Methodsmentioning

confidence: 99%

Reversion of breast epithelial polarity alterations caused by obesity

et al. 2023

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Molecular links between breast cancer risk factors and pro-oncogenic tissue alterations are poorly understood. The goal of this study was to characterize the impact of overweight and obesity on tissue markers of risk, using normal breast biopsies, a mouse model of diet-induced obesity, and cultured breast acini. Proliferation and alteration of epithelial polarity, both necessary for tumor initiation, were quantified by immunostaining. High BMI (>30) and elevated leptin were associated with compromised epithelial polarity whereas overweight was associated with a modest increase in proliferation in human and mice mammary glands. Human serum with unfavorable adipokine levels altered epithelial polarization of cultured acini, recapitulating the effect of leptin. Weight loss in mice led to metabolic improvements and restored epithelial polarity. In acini cultures, alteration of epithelial polarity was prevented by antioxidants and could be reverted by normalizing culture conditions. This study shows that obesity and/or dietary factors modulate tissue markers of risk. It provides a framework to set target values for metabolic improvements and to assess the efficacy of interventional studies aimed at reducing breast cancer risk.

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Section: Methodsmentioning

confidence: 99%

Reversion of breast epithelial polarity alterations caused by obesity

et al. 2023

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Key takeaways for knowledge expansion of early-career scientists conducting Transdisciplinary Research in Energetics and Cancer (TREC): a report from the TREC Training Workshop 2022

et al. 2023

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The overall goal of the annual Transdisciplinary Research in Energetics and Cancer (TREC) Training Workshop is to provide transdisciplinary training for scientists in energetics and cancer and clinical care. The 2022 Workshop included 27 early-to-mid career investigators (trainees) pursuing diverse TREC research areas in basic, clinical, and population sciences. The 2022 trainees participated in a gallery walk, an interactive qualitative program evaluation method, to summarize key takeaways related to program objectives. Writing groups were formed and collaborated on this summary of the 5 key takeaways from the TREC Workshop. The 2022 TREC Workshop provided a targeted and unique networking opportunity that facilitated meaningful collaborative work addressing research and clinical needs in energetics and cancer. This report summarizes the 2022 TREC Workshop’s key takeaways and future directions for innovative transdisciplinary energetics and cancer research.

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