Diet effects on enterocyte development

Smith, Michael W.

doi:10.1079/pns19920027

Cited by 15 publications

(17 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Occurrence of lactase activity in intestinal mucosa of slaughter weight cattle, observed in this study, is similar to the observations of Smith (1992) in 46-d-old mice. The extent of lactase activity is related to migration rate of enterocytes along the villus crypt axis and time taken for biosynthesis of lactase, which is longer than for other carbohydrases (Hauri et al 1985).…”

Section: Protein Content and Carbohydrase Activitiessupporting

confidence: 78%

Activity of intestinal mucosal membrane carbohydrases in cattle of different breeds

Mir¹,

Bailey²,

Mir³

et al. 1997

Can. J. Anim. Sci.

View full text Add to dashboard Cite

. Activity of intestinal mucosal membrane carbohydrases in cattle of different breeds. Can. J. Anim. Sci. 77: 441-446. A study was conducted to determine differences in length of intestinal villi and crypts and activity of mucosal carbohydrases of several breeds of beef cattle. Tissue samples, from three locations in the small intestine, were obtained from heifers and steers of Wagyu (W) × Angus (W × A), W × Hereford (W × H) and W × Holstein (W × O) crossbred cattle and from Holstein, Parthenais and Piedmontese steers at slaughter. In W × A cattle villi were shorter and crypts were longer (P < 0.05) than in cattle of other breeds. Mucosal protein concentration was highest (P < 0.05) in the mid-and distal intestinal regions in the W × A cattle. Maltase activity was highest (P < 0.05) for W × H heifers and least (P < 0.05) for W × A heifers in the proximal intestinal region. Holstein and Piedmontese steers had the highest ADG, and Holstein steers had the highest lactase activity in the mid-intestinal region. Lactase activity in the mid-intestinal region appeared to be weakly associated with ADG of cattle (r = 0.454, P = 0.015, n = 28). These data suggest that differences due to breed of cattle exist in villus and crypt lengths and mucosal carbohydrase activity; however, the influence of these intestinal parameters on cattle performance may be relatively small. . Chez les sujets W × A, les villosités étaient plus courtes et les cryptes plus longues (P < 0,05) que chez les autres groupes génétiques. Également chez les W × A la concentration protéique de la muqueuse atteignait des valeurs maximales (P < 0,05) dans les régions médiane et distale de l'intestin. La plus forte activité de la maltase (P < 0,05) était observée chez les génisses W × H et la plus faible (P < 0,05) chez les génisses W × A dans la région proximale de l'intestin. Les bouvillons Holstein et Piedmontais affichaient le GMQ le plus élevé, les premiers manifestant en outre la plus forte activité de la lactase dans la région intestinale médiane, quoique ces deux caractères ne soient que faiblement interreliés (r = 0,454, P = 0,015; n = 28). Ces observations portent à conclure qu'il y a effectivement des différences selon la race affectant la longueur des villosités et des cryptes intestinales ainsi que de l'activité des carbohydrases de la muqueuse. Il semble toutefois que l'influence de ces paramètres soit relativement faible.Mots clés: Villosité intestinale, crypte, cellobioase, maltase, lactase, bovin à viande Cattle breeds vary in their ability to grow and produce lean meat with different quality characteristics (Newman et al. 1994). It can be expected that this variation is related to genetic differences in their ability to acquire and partition nutrients from feed to different tissue components. Kreikemeier et al. (1990) found the type of diet and level of intake to significantly affect pancreatic weight and carbohydrate digesting enzyme abundance and activity in the small intestine. These authors studied steers of the Holstein and Longhorn bre...

show abstract

Section: Protein Content and Carbohydrase Activitiessupporting

confidence: 78%

Activity of intestinal mucosal membrane carbohydrases in cattle of different breeds

Mir¹,

Bailey²,

Mir³

et al. 1997

Can. J. Anim. Sci.

View full text Add to dashboard Cite

show abstract

“…The data on lactase and sucrase activities support the role of LF in the early intestinal development and show that LF directly promotes enterocyte differentiation. Sucrase and lactase show a sugar-dependent rapid increase in the first days of life (6). Interestingly, a rapid increase is observed in disaccharidase activities in jejunal fluid during the first, second, and third weeks of life (30) in parallel with the decrease in LF in human milk (15).…”

mentioning

confidence: 90%

“…To monitor cell differentiation, we determined sucrase and lactase activities. The latter increases with age in the first weeks of life and it was increased in milk-fed more than in formula-fed infants (6,7).…”

mentioning

confidence: 94%

See 1 more Smart Citation

Lactoferrin Induces Concentration-Dependent Functional Modulation of Intestinal Proliferation and Differentiation

et al. 2007

View full text Add to dashboard Cite

Human milk stimulates intestinal development through the effects of various moieties. Lactoferrin (LF) is a glycoprotein of human milk whose concentration is highest in colostrum decreasing in mature milk. LF promotes enterocyte growth in intestinal cell lines. We tested the hypothesis that LF induces a distinct effect on enterocyte proliferation and differentiation, depending on its concentration. We examined the dose-related effects by humannative LF (N-LF) in Caco-2 (human colon adenocarcinoma) cells. At high concentrations, N-LF stimulated cell proliferation in immature Caco-2 cells, as judged by 3 H-thymidine incorporation. In contrast, sucrase and lactase activities were increased at low but not high LF concentrations and their mRNA were also increased, indicating a transcriptional effect. Because iron binds specific LF sites, we compared the potency of N-LF and iron-saturated LF (I-LF) and found the native form more potent. Finally, we tested the effects by bovine LF (bLF) in the same system and found the latter more potent than the human isoform in inducing cell growth and lactase expression. These results suggest that LF directly induces enterocyte growth and proliferation, depending on its concentration, thereby regulating the earlyx postnatal intestinal development. bLF could be added to infant formula as a growth factor in selected intestinal diseases.

show abstract

“…Other factors affecting differentiation include interactions taking place between enterocytes and the underlying mesodermal tissue (Haffen et al 1989) and between enterocytes and the gut-associated immune system (Smith, 1991). Change of diet and the proliferative state of the gut further affect the way in which enterocytes express microvillus structure and digestive and absorptive functions (Smith, 1992). All these factors should be considered by anyone wishing to understand how diet and health affect intestinal function.…”

mentioning

confidence: 99%