Diet and the Risk of Invasive Cervical Cancer Among White Women in the United States

Rg, Ziegler; La, Brinton; Rf, Hamman; Hf, Lehman; Rs, Levine; Mallin, Katherine; Sa, Norman; Jf, Rosenthal; Ac, Trumble; Rn, Hoover

doi:10.1093/oxfordjournals.aje.a115678

Cited by 96 publications

(27 citation statements)

References 30 publications

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“…Liu et al (1993) found no association between calcium intake and cervical dysplasia, with a multivariate-adjusted OR for the highest to lowest level of intake of 0.9 (95% CI 0.4-2.1; trend P ¼ 0.58). Ziegler et al (1990Ziegler et al ( , 1991 showed no association between dairy product intake and carcinoma in situ or invasive cervical cancer. Furthermore, to our knowledge, the association between vitamin D and cervical neoplasia has not been analyzed.…”

Section: Discussionmentioning

confidence: 89%

“…Vitamin D modulates calcium metabolism, inhibits cellular proliferation, induces differentiation and apoptosis and (Ziegler et al, 1991) inhibits angiogenesis in normal and malignant breast cells Xue et al, 1999;Shin et al, 2002;Cui and Rohan, 2006;Deeb et al, 2007). With regard to cervical cancer, however, only a few epidemiological studies have sought to determine the association between calcium and vitamin D and cancer risk (Ziegler et al, 1990(Ziegler et al, , 1991Liu et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

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Association between dietary calcium and vitamin D intake and cervical carcinogenesis among Japanese women

et al. 2010

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Background/Objectives: To examine the association between dietary calcium and vitamin D intake and cervical neoplasia risk, we conducted a case-control study. Subjects/Methods: We selected 405 incident cervical neoplasias (333 invasive carcinomas and 72 cervical intraepithelial neoplasias grade III (CIN3)) and 2025 age-matched non-cancer controls. Dietary information was collected using a semiquantitative food-frequency questionnaire (FFQ). The effect on cervical neoplasia risk was evaluated using conditional logistic regression models. Results: The inverse association between invasive carcinoma and milk, yogurt and fish was observed. On the other hand, the marginally significant inverse association between CIN3 and tofu and green leafy vegetables was observed. Compared with the lowest quartile (Q1) of calcium intake, adjusted odds ratios (ORs) for each of the three upper quartiles (Q2, Q3 and Q4) on invasive carcinoma risk were 0.86 (95% confidence interval (CI) 0.63-1.17), 0.50 (95% CI 0.34-0.73) and 0.68 (95% CI 0.48-0.97), respectively (P for trend ¼ 0.004). However, no association between calcium and cancer risk was evident among CIN3 cases (P for trend ¼ 0.528). Vitamin D intake showed a similar inverse association (Q2: OR 1.03, 95% CI 0.74-1.44; Q3: OR 0.80, 95% CI 0.56-1.15; and Q4: OR 0.64, 95% CI 0.43-0.94; P for trend ¼ 0.013). Similar to calcium, no association between vitamin D intake among CIN3 was evident (P for trend ¼ 0.109). An inverse association with calcium was evident in women whose vitamin D intake was low. However, this combined effect was not significant (invasive carcinoma: interaction P ¼ 0.819; and CIN3: interaction P ¼ 0.101). Conclusion: We found an inverse association between dietary calcium and vitamin D intake and cervical neoplasia risk among a group of Japanese women.

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Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Association between dietary calcium and vitamin D intake and cervical carcinogenesis among Japanese women

et al. 2010

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“…According to Ziegler et al (1990Ziegler et al ( , 1992, this dose-response curve relationship can be observed during prenatal glutamine supplementation in humans, particularly following bone marrow transplantation. For some supplements, such as β-glucan, a characteristic dose-response curve is observed at any given time point.…”

Section: Discussionmentioning

confidence: 96%

“…One of the first studies reporting the safety of glutamine use in clinical nutrition was conducted by Ziegler et al (1990). According to their study, the metabolic effectiveness of glutamine in bone marrow transplantation was observed at a dose of 0.57 g glutamine/kg bw/day (Ziegler et al, 1992).…”

Section: Discussionmentioning

confidence: 99%

Antigenotoxic and antimutagenic effects of glutamine supplementation on mice treated with cisplatin

Pesarini¹,

Sg²,

Ap³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. We evaluated the effects of glutamine on clastogenic and genotoxic damage prevention caused by the administration of cisplatin. 4821©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 13 (3): 4820-4830 (2014) Glutamine prevents DNA damage Forty Swiss mice were divided into 8 experimental groups: G1 and G2, which were control groups; G3, G4, and G5, which were administered [2 doses of glutamine (orally)] separated by a 24-h period (150, 300, and 600 mg/kg, respectively), and a dose of phosphate-buffered saline by intraperitoneal injection; G6, G7, and G8, which were treated in the same manner as the previous groups, but received cisplatin rather than phosphate-buffered saline. The antimutagenicity groups showed damage reduction percentages of 79.05, 80.00, and 94.27% at the time point T1, 53.18, 67.05, and 64.74 at time point T2 for the 150, 300, and 600 mg/kg doses of glutamine, respectively. Antigenotoxic activity was evident for all 3 doses with damage reduction percentages of 115.05, 119.06, and 114.38 for the doses of glutamine of 150, 300, and 600 mg/ kg, respectively. These results suggest that further studies are needed to confirm the clastogenic activity of glutamine. However, our results may lead to rational strategies for supplementation of this antioxidant as an adjuvant in cancer treatment or for preventing genomic lesions.

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“…Studies of the effect of dietary intake of Vitamin A on the risk of cervical cancer or dysplasia, a precursor of cervical cancer, have yielded conflicting results. Some have reported that lower intake levels of dietary retinol or beta-carotene were associated with an elevated risk of cervical cancer or dysplasia (Marshall et al, 1983;Liu et al, 1993;WylieRosett et al, 1984), whereas others did not (De Vet et al, 1991;Ziegler et al, 1990;La Vecchia et al, 1988). Findings from serum investigations have also been inconsistent.…”

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confidence: 99%

Decreased serum retinol levels in women with cervical dysplasia

Shimizu

Nagata²,

Komatsu³

et al. 1996

Br J Cancer

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Sin.ry To examine the relationship of dietary and serum vitamin A to the risk of cervical dysplasia, a case-control study was conducted in Miyagi, Japan. Cases were 137 women who were found by Papanicolaou test screening and histological examination provided by Miyagi Cancer Society between October 1987 and September 1988 to have cervical dysplasia. Controls were selected from participants of the general health examination provided by the Society and individually matched to cases on age and screening date. The consumption of retinol or carotene-rich foods during the past 7 days was assessed at interview. Information was also collected about other risk factors of cervical dysplasia, such as reproductive histories and sexual behaviour. The mean serum retinol levels were significntly lower among cases compared with controls, although dietary intake levels of retinol and carotene were not different between the two groups. When examined by tertile, the risk of cervical dysplasia was significantly higher among women in the highest tertile of dietary vitamin A level. An inverse association was observed between serum retinol level and risk of cervical dysplasia, although it did not achieve statistical significance.

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Diet and the Risk of Invasive Cervical Cancer Among White Women in the United States

Cited by 96 publications

References 30 publications

Association between dietary calcium and vitamin D intake and cervical carcinogenesis among Japanese women

Association between dietary calcium and vitamin D intake and cervical carcinogenesis among Japanese women

Antigenotoxic and antimutagenic effects of glutamine supplementation on mice treated with cisplatin

Decreased serum retinol levels in women with cervical dysplasia

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