2014
DOI: 10.4238/2014.july.2.11
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Abstract: ABSTRACT. We evaluated the effects of glutamine on clastogenic and genotoxic damage prevention caused by the administration of cisplatin. 4821©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 13 (3): 4820-4830 (2014) Glutamine prevents DNA damage Forty Swiss mice were divided into 8 experimental groups: G1 and G2, which were control groups; G3, G4, and G5, which were administered [2 doses of glutamine (orally)] separated by a 24-h period (150, 300, and 600 mg/kg, respectively), and a dose of ph… Show more

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Cited by 5 publications
(3 citation statements)
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“…Also, according to the results observed in other experiments from our research group ( Oliveira et al , 2009a , 2013 ; Mauro et al. , 2010 ; Pesarini et al , 2014 ; Navarro et al , 2015 ), the baseline frequency of micronuclei can be greater than the frequency observed for the animals treated with IR-01 in the present study. For example, according to Oliveira et al (2015b) , the baseline frequency of micronuclei in Swiss female mice may reach 11.00 ± 3.16.…”
Section: Discussionsupporting
confidence: 77%
“…Also, according to the results observed in other experiments from our research group ( Oliveira et al , 2009a , 2013 ; Mauro et al. , 2010 ; Pesarini et al , 2014 ; Navarro et al , 2015 ), the baseline frequency of micronuclei can be greater than the frequency observed for the animals treated with IR-01 in the present study. For example, according to Oliveira et al (2015b) , the baseline frequency of micronuclei in Swiss female mice may reach 11.00 ± 3.16.…”
Section: Discussionsupporting
confidence: 77%
“…The simultaneous treatment protocol allows both modes of action to occur simultaneously when the chemotherapeutic agent and the possible chemoprotective agent are applied simultaneously . Effects such as these are described for β-glucan, glutamine, , dietary fibers such as wheat, and resistant starch, among others. However, it has also been described for synthetic compounds such as isocoumarin, an acid (compound 1 , Figure ), and an ester (compound 2 , Figure ) derived from 4-AA .…”
Section: Discussionmentioning
confidence: 99%
“…The administration route and time required for absorption of the tested foods or compounds should be taken into consideration (Primo et al, 2010;Pesarini et al, 2014). The present study employed protocols recommended in the literature to classify the mode of action of the A. aculeata oils, thus reporting these modes of action in the literature in a pioneering manner.…”
Section: Discussionmentioning
confidence: 99%