Diet and risk of diabetic retinopathy: a systematic review

Dow, C.; Mancini, Francesca Romana; Rajaobelina, Kalina; Boutron‐Ruault, Marie‐Christine; Balkau, Beverley; Bonnet, Fabrice; Fagherazzi, Guy

doi:10.1007/s10654-017-0338-8

Cited by 87 publications

(57 citation statements)

References 93 publications

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“…Meanwhile, in the subgroup without complications no significant differences in dietary zinc intake between groups, and an undetectable heterogeneity (I 2 = 0.0%) were found ( [34]. In patients with diabetic nephropathy, diet therapies, such as protein restriction are commonly advised [37,38]. It is well known that zinc intake correlates directly with protein intake, as these two nutrients share the same food sources [39].…”

Section: Discussionmentioning

confidence: 99%

Dietary zinc intake and whole blood zinc concentration in subjects with type 2 diabetes versus healthy subjects: A systematic review, meta-analysis and meta-regression

Fernández‐Cao

Warthon-Medina

Morán

et al. 2018

Journal of Trace Elements in Medicine and Biology

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The aim of this systematic review, meta-analysis and meta-regression was to examine the relationship between type 2 diabetes mellitus (T2DM) and concentration of zinc in whole blood, as well as dietary zinc intake. Searches were performed using Ovid MEDLINE, Embase (Ovid) and The Cochrane Library (CENTRAL). Observational studies conducted on diabetic and healthy adults, with data on dietary zinc intake and/or concentration of zinc in whole blood, were selected. The search strategy yielded 11,150 publications and the manual search 6, of which 11 were included in the meta-analyses. Mean difference (MD) and 95% confidence interval (CI), were calculated using the generic inverse-variance method with random-effects models. Heterogeneity was assessed by the Cochran Q-statistic and quantified by the I statistic. Meta-regressions and stratified analysis were used to examine whether any covariate had influence on the results. The pooled MD for the dietary zinc intake meta-analysis was -0.40 (95% CI: -1.59 to 0.79; I = 61.0%). Differences between diabetic and non-diabetic subjects became significant in the presence of complications associated with diabetes (MD = -2.26; 95% CI: -3.49 to -1.02; I = 11.9%). Meta-regression showed that for each year since the diagnosis of diabetes the concentration of zinc in whole blood decreased in diabetic patients regarding healthy controls [MD (concentration of zinc in blood) = 732.61 + (-77.88303) × (duration of diabetes in years)], which is not generally explained by a lower intake of zinc.

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Section: Discussionmentioning

confidence: 99%

Dietary zinc intake and whole blood zinc concentration in subjects with type 2 diabetes versus healthy subjects: A systematic review, meta-analysis and meta-regression

Fernández‐Cao

Warthon-Medina

Morán

et al. 2018

Journal of Trace Elements in Medicine and Biology

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“…Based on the retrospective analysis of this study, patients with T1D were advised to reduce their total dietary fat to ,30% and the saturated fat to ,10%, as was formerly recommended by the American Diabetes Association. To this day, the evidence for the effect of dietary fat intake on DR incidence and progression remains inconclusive, and a potential positive effect of specific saturated fatty acids (SFAs) and unsaturated fatty acids has been raised (15)(16)(17)(18).…”

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confidence: 99%

In contrast to Western diet, a plant‐based, high‐fat, low‐sugar diet does not exacerbate retinal endothelial injury in streptozotocin‐induced diabetes

et al. 2019

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Controversy remains about how diet affects the vascular endothelial dysfunction associated with disordered insulin‐glucose homeostasis. It is postulated that the type and level of certain macronutrients contribute to endothelial dysfunction in vascular diabetes complications. However, it is not well understood how specific macronutrients affect the molecular inflammatory response under conditions of hyperglycemia. Here, we examined retinal microvascular endothelial injury in streptozotocin (STZ)‐diabetic rats fed a laboratory Western diet (WD). WD, characterized by its high content of saturated fat, cholesterol, and sugar, significantly increased retinal leukocyte accumulation and endothelial injury in the STZ‐diabetic rats. Suppression of endothelial NF‐κB signaling in the STZ model reduced the WD‐induced increase in leukocyte accumulation. To isolate the effect of dietary fat, we generated high‐fat diets with varying fatty acid balance and type. These diets contained moderate amounts of carbohydrates but no sugar. We found that neither high levels of saturated or unsaturated fats per se increased retinal leukocyte accumulation and endothelial injury in the STZ‐diabetic rat model but that the combination of high levels of dietary cholesterol with specific saturated fatty acids that are abundant in WD exacerbated leukocyte accumulation and endothelial injury in the retinas of STZ‐diabetic rats.—Barakat, A., Nakao, S., Zandi, S., Sun, D., Schmidt‐Ullrich, R., Hayes, K. C., Hafezi‐Moghadam, A. In contrast to Western diet, a plant‐based, high‐fat, low‐sugar diet does not exacerbate retinal endothelial injury in streptozotocin‐induced diabetes. FASEB J. 33, 10327–10338 (2019). http://www.fasebj.org

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“…Diabetic retinopathy is a severe diabetic complication and is currently the leading cause of blindness worldwide, but its pathogenesis is not yet clear, and its therapeutic effect is not promising [19]. According to Siddiqui A et al, lncRNA-ANRIL might be a genetic predictor for DR [20].…”

Section: Discussionmentioning

confidence: 99%

The clinical significance of long non-coding RNA ANRIL level in diabetic retinopathy

et al. 2019

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Aim To analyse the expression of lncRNA-ANRIL and other related factors in different human body fluids, explore the clinical significance of ANRIL and validate whether ANRIL is interrelated with the renin-angiotensin system and NF-κB signalling pathway. Methods Ninety-one patients were included in this cross-sectional study and were divided into the NDM group (20 patients), DM group (25 patients), NPDR group (21 patients) and PDR group (25 patients). Basic information and samples of serum, aqueous fluid and vitreous fluid were collected before vitrectomy or intravitreal injection. The transcription and levels of ANRIL and other related factors were detected by RT-PCR and ELISA. Statistical Package for Social Sciences software was used for statistical analysis. Results ANRIL expression varied among different groups and body fluids. There was no difference in ANRIL expression between the NDM and DM groups, but the level of ANRIL was significantly lower in the DM group than in the NPDR and PDR group. In vitreous fluid, ANRIL expression was positively correlated with Ang II, p65 and VEGF expression in the PDR group. The expression of ANRIL in serum was not significantly correlated with age or the random blood sugar but was positively correlated with diabetic duration and HbAc1 level. Conclusions Levels of lncRNA-ANRIL are higher in DR patient and correlated with the progression of DR that may be used as an indicator to predict the development of DR. The activation of the RAS and the NF-κB pathway may be closely related to the upregulation of ANRIL. Clinical trial number ChiCTR1800017500. Registry Chinese Clinical Trial Registry. Keywords Diabetic retinopathy • Antisense non-coding RNA at the INK4 locus • Renin-angiotensin system • NF-κB pathway • Vascular endothelial growth factor This article belongs to the topical collection Eye Complications of Diabetes managed by Giuseppe Querques.

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Diet and risk of diabetic retinopathy: a systematic review

Cited by 87 publications

References 93 publications

Dietary zinc intake and whole blood zinc concentration in subjects with type 2 diabetes versus healthy subjects: A systematic review, meta-analysis and meta-regression

Dietary zinc intake and whole blood zinc concentration in subjects with type 2 diabetes versus healthy subjects: A systematic review, meta-analysis and meta-regression

In contrast to Western diet, a plant‐based, high‐fat, low‐sugar diet does not exacerbate retinal endothelial injury in streptozotocin‐induced diabetes

The clinical significance of long non-coding RNA ANRIL level in diabetic retinopathy

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