Diet and gut microbiota manipulation for the management of Crohn's disease and ulcerative colitis

Svolos, Vaios; Gkikas, Konstantinos; Gerasimidis, Konstantinos

doi:10.1017/s0029665121002846

Cited by 9 publications

(8 citation statements)

References 55 publications

(196 reference statements)

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“…The gut microbiome serves various functions, including energy harvesting, the neutralisation of carcinogens and drugs, and the modulation of intestinal mobility and immune responses [ 1 , 2 , 3 ]. Microbial dysbiosis can aggravate various diseases, including diabetes, obesity, Crohn’s disease, and inflammatory bowel disease [ 1 , 4 , 5 , 6 ]. In addition, the gut microbiota is highly sensitive to exogenous stressors, including nanoparticles (NPs) and persistent organic pollutants (POPs) [ 7 , 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Intestinal Microecology of Mice Exposed to TiO2 Nanoparticles and Bisphenol A

Yang

Tan

et al. 2022

Foods

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Exposure to titanium dioxide nanoparticles (TiO2 NPs) and bisphenol A (BPA) is ubiquitous, especially through dietary and other environmental pathways. In the present study, adult C57BL/6J mice were exposed to TiO2 NPs (100 mg/kg), BPA (0, 5, and 50 mg/kg), or their binary mixtures for 13 weeks. The 16S rDNA amplification sequence analysis revealed that co-exposure to TiO2 NPs and BPA altered the intestinal microbiota; however, this alteration was mainly caused by TiO2 NPs. Faecal metabolomics analysis revealed that 28 metabolites and 3 metabolic pathways were altered in the co-exposed group. This study is the first to reveal the combined effects of TiO2 NPs and BPA on the mammalian gut microbial community and metabolism dynamics, which is of great value to human health. The coexistence of TiO2 NPs and BPA in the gut poses a potential health risk due to their interaction with the gut microbiota.

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Section: Introductionmentioning

confidence: 99%

Intestinal Microecology of Mice Exposed to TiO2 Nanoparticles and Bisphenol A

Yang

Tan

et al. 2022

Foods

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“…The change of gut microbiota in patients with colitis is closely related to infection. Numerous studies have shown that colitis may be affected by changes in microbial communities caused by diet or other factors ( 6 , 39 , 40 ). In this study, we found that DSS or CP treatment had a significant effect in colonic microbial composition.…”

Section: Discussionmentioning

confidence: 99%

“…The gastrointestinal tract is considered to be an ecosystem composed of gastrointestinal epithelial cells, mucus layer, immune cells and gut microbiota. Previous evidence showed the relevance between dysregulation of the gut microbiota with the progression of UC (5,6). Besides, several studies believed that UC was also related to immune imbalance and macrophages played important roles in the development of UC (7,8).…”

Section: Introductionmentioning

confidence: 99%

Collagen peptide promotes DSS-induced colitis by disturbing gut microbiota and regulation of macrophage polarization

Cui²,

Feng³

et al. 2022

Front. Nutr.

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Ulcerative colitis (UC) is an inflammatory bowel disease caused by mucosal immune system disorder, which has increased steadily all over the world. Previous studies have shown that collagen peptide (CP) has various beneficial biological activities, it is not clear whether the effect of CP on UC is positive or negative. In this study, 2.5% dextran sulfate sodium (DSS) was used to establish acute colitis in mice. Our results suggested that CP supplementation (200, 400 mg/kg/day) promoted the progression of colitis, increased the expression of inflammatory factors and the infiltration of colonic lamina propria macrophages. Gut microbiota analysis showed the composition changed significantly and inflammation promoted bacteria was after CP treatment. Meanwhile, the effect of CP on macrophage polarization was further determined in Raw264.7 cell line. The results showed that CP treatment could increase the polarization of M1 macrophages and promote the expression of inflammatory factors. In conclusion, our results showed that CP treatment could disrupt the gut microbiota of host, promote macrophage activation and aggravate DSS-induced colitis. This may suggest that patients with intestinal inflammation should not take marine derived CP.

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“…Genetic predisposition explains about 25% of the overall incidence of IBD, and environment factors play an increasingly considerable role in the development of IBD [ 3 , 4 ]. Therefore, manipulation of the susceptibility of gene expression via dietary intervention might help to reduce the risk of IBD [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Milk-Derived Extracellular Vesicles on the Colonic Transcriptome and Proteome in Murine Model

Zhao

Wang

et al. 2022

Nutrients

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Evidence shows that effective nutritional intervention can prevent or mitigate the risk and morbidity of inflammatory bowel disease (IBD). Bovine milk extracellular vesicles (mEVs), a major bioactive constituent of milk, play an important role in maintaining intestinal health. The aims of this study were to assess the effects of mEV pre-supplementation on the colonic transcriptome and proteome in dextran sulphate sodium (DSS)-induced acute colitis, in order to understand the underlying molecular mechanisms of mEV protection against acute colitis. Our results revealed that dietary mEV supplementation alleviated the severity of acute colitis, as evidenced by the reduced disease activity index scores, histological damage, and infiltration of inflammatory cells. In addition, transcriptome profiling analysis found that oral mEVs significantly reduced the expression of pro-inflammatory cytokines (IL-1β, IL-6, IL-17A and IL-33), chemokine ligands (CXCL1, CXCL2, CXCL3, CXCL5, CCL3 and CCL11) and chemokine receptors (CXCR2 and CCR3). Moreover, oral mEVs up-regulated 109 proteins and down-regulated 150 proteins in the DSS-induced murine model, which were involved in modulating amino acid metabolism and lipid metabolism. Collectively, this study might provide new insights for identifying potential targets for the therapeutic effects of mEVs on colitis.

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Diet and gut microbiota manipulation for the management of Crohn's disease and ulcerative colitis

Cited by 9 publications

References 55 publications

Intestinal Microecology of Mice Exposed to TiO2 Nanoparticles and Bisphenol A

Intestinal Microecology of Mice Exposed to TiO2 Nanoparticles and Bisphenol A

Collagen peptide promotes DSS-induced colitis by disturbing gut microbiota and regulation of macrophage polarization

Effects of Milk-Derived Extracellular Vesicles on the Colonic Transcriptome and Proteome in Murine Model

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