Diet and chronic obstructive pulmonary disease: independent beneficial effects of fruits, whole grains, and alcohol (the MORGEN study)

Tabak, Cora; Smit, Henriëtte A.; Heederik, Dick; Ocké, Marga C.; Kromhout, Daan

doi:10.1046/j.1365-2222.2001.01064.x

Cited by 131 publications

(144 citation statements)

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“…Still, the results suggest a protective effect of a high intake of fruit against COPD. This is in agreement with the results of most cross-sectional studies Tabak et al, 1999Tabak et al, , 2001aButland et al, 2000) and with the results of two of the three longitudinal studies (Butland et al, 2000;Miedema et al, 1993;Carey et al, 1998). Miedema et al (1993) observed an inverse relation between baseline consumption of total and especially solid fruit ( ¼ apples, pears) and 25 y chronic lung disease incidence in the Dutch cohort of the Seven Countries Study.…”

Section: Discussionsupporting

confidence: 89%

“…Butland et al (2000) reported a nonsignificant trend towards an inverse relation between baseline apple consumption and change in FEV 1 . As has been observed earlier (Tabak et al, 2001a) the effect of fruit intake appeared to be largely independent of that of alcohol consumption. In none of the longitudinal studies that investigated vitamin C intake in relation to indicators of COPD (including our own) a clear association was observed (Miedema et al, 1993;Butland et al, 2000).…”

Section: Discussionsupporting

confidence: 76%

“…Cross-sectional studies published in 1990 and 1994 suggested an inverse association between fish consumption and COPD related outcomes . However, all cross-sectional studies published in later years reported negative findings (Cook et al, 1997;Fluge et al, 1998;Tabak et al, 1999Tabak et al, , 2001aButland et al, 2000). In the only individuallevel longitudinal study, no association of fish consumption with 25 y incidence of chronic lung disease was observed (Miedema et al, 1993).…”

Section: Introductionmentioning

confidence: 94%

“…Several cross-sectional epidemiological studies have suggested that dietary antioxidants and foods rich in antioxidants (ie fruit and vegetables) may protect the airways against oxidant-mediated damage leading to COPD Tabak et al, 1999Tabak et al, , 2001aButland et al, 2000). Only three longitudinal studies on the relation between diet and COPD-related outcomes have been published.…”

Section: Introductionmentioning

confidence: 99%

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Diet and 20-year chronic obstructive pulmonary disease mortality in middle-aged men from three European countries

et al. 2002

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Objective: To investigate the relation of baseline antioxidant, fruit, vegetable and fish intake with 20 y chronic obstructive pulmonary disease (COPD) mortality in middle-aged men from three European countries. Design: Prospective study (1970 -1990). Setting: Five population-based cohorts of middle-aged men from Finland, Italy and The Netherlands. Subjects: A total of 2917 men aged 50 -69 y at baseline. Methods: Baseline information on diet was collected using the cross-check dietary history method. After 20 y of follow-up the underlying cause of death of those who died was established centrally. Survival analyses were performed using the Cox Proportional Hazards Model. Results: After adjustment for age, smoking and country, we observed an inverse trend (P-trend < 0.05) of 20 y COPD mortality across tertiles of fruit and vitamin E intake. No trend was observed for vegetables, fish, vitamin C and b-carotene. When modelled continuously, a 100 g increase in fruit intake was associated with a 24% lower COPD mortality risk (RR ¼ 0.76, 95% CI ¼ 0.60 -0.92). For vitamin E intake (per 5 mg) the RR was 0.77 (95% CI ¼ 0.55 -1.06), after adjustment for age, smoking and country. Additional adjustment for body mass index, total energy intake and alcohol consumption reduced the RR to 0.86 (95% CI ¼ 0.69 -1.07, P ¼ 0.12) for fruit and 0.93 (95% CI ¼ 0.65 -1.33) for vitamin E. Conclusions: Our results suggest a protective effect of fruit and possibly vitamin E intake against COPD. No effect was observed for intake of vitamin C, b-carotene, vegetables and fish.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 76%

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

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Diet and 20-year chronic obstructive pulmonary disease mortality in middle-aged men from three European countries

et al. 2002

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“…Higher levels of dietary or plasma antioxidants have been associated with better pulmonary function, as demonstrated by a higher level and lower rate of decline of the forced expiratory volume in 1 s (FEV 1 ), and a decreased risk of chronic obstructive pulmonary disease (COPD) [35,36]. Major nonenzymatic antioxidants present at respiratory tract surfaces include ascorbate, urate, α-tocopherol, reduced glutathione (GSH), mucins, and albumin.…”

Section: Oxidative Stress In the Lungmentioning

confidence: 99%

Antioxidants in cystic fibrosis☆Conclusions from the CF Antioxidant Workshop, Bethesda, Maryland, November 11-12, 2003

Cantin

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et al. 2007

Free Radical Biology and Medicine

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Although great strides are being made in the care of individuals with cystic fibrosis (CF), this condition remains the most common fatal hereditary disease in North America. Numerous links exist between progression of CF lung disease and oxidative stress. The defect in CF is the loss of function of the transmembrane conductance regulator (CFTR) protein; recent evidence that CFTR expression and function are modulated by oxidative stress suggests that the loss may result in a poor adaptive response to oxidants. Pancreatic insufficiency in CF also increases susceptibility to deficiencies in lipophilic antioxidants. Finally the airway infection and inflammatory processes in the CF lung are potential sources of oxidants that can affect normal airway physiology and contribute to the mechanisms causing characteristic changes associated with bronchiectasis and loss of lung function. These multiple abnormalities in the oxidant/antioxidant balance raise several possibilities for therapeutic interventions that must be carefully assessed. IntroductionCystic fibrosis (CF) is the most common fatal disease caused by a single gene defect in Europe and North America [1,2]. The defective gene was identified in 1989 [3][4][5] and shown to encode the cystic fibrosis trans-membrane conductance regulator protein (CFTR). CFTR is a cyclic AMP-regulated anion channel with greatest selectivity for chloride, and bicarbonate [6][7][8]. Furthermore, CFTR regulates sodium transport across epithelial membranes through interactions with the epithelial sodium channel ENaC [9], and facilitates the trans-membrane export of the small organic anionic peptide glutathione [10]. The expression of CFTR is located in the apical membrane of epithelial cells that line mucous membranes and submucosal glands ☆ A list of participants may be found in the Acknowledgments.

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Epidemiology, Risk Factors and Pathophysiology

et al. 2013

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Diet and chronic obstructive pulmonary disease: independent beneficial effects of fruits, whole grains, and alcohol (the MORGEN study)

Abstract: Our results suggest independent beneficial effects of fruits, whole grains and alcohol on COPD that are largely additive and cannot be explained by smoking habits.

Cited by 131 publications

References 37 publications

Diet and 20-year chronic obstructive pulmonary disease mortality in middle-aged men from three European countries

Diet and 20-year chronic obstructive pulmonary disease mortality in middle-aged men from three European countries

Antioxidants in cystic fibrosis☆Conclusions from the CF Antioxidant Workshop, Bethesda, Maryland, November 11-12, 2003

Epidemiology, Risk Factors and Pathophysiology

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