Diet and 20-year chronic obstructive pulmonary disease mortality in middle-aged men from three European countries

Walda, I.; Tabak, Cora; Smit, Henriëtte A.; Rásänen, Leena; Fidanza, F; Menotti, Alessandro; Nissinen, Aulikki; Feskens, Edith J. M.; Kromhout, Daan

doi:10.1038/sj.ejcn.1601370

Cited by 110 publications

(95 citation statements)

References 25 publications

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“…Previously, an inverse association between consumption of fruits, but not vegetables, and COPD mortality was observed [36]. Conversely, a diet characterized by high consumption of fruits, vegetables, whole grains, polyunsaturated fatty acids, nuts, and long-chain omega-3 fats and low consumption of red and processed meat, refined grains, and sugar-sweetened drinks was associated with a lower risk of COPD in men and women in the United States [37].…”

Section: Discussionmentioning

confidence: 99%

Oxidant status, iron homeostasis, and carotenoid levels of COPD patients with advanced disease and LTOT

Kentson

Leanderson

Jacobson

et al. 2018

European Clinical Respiratory Journal

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Background: The pathogenesis of chronic obstructive pulmonary disease (COPD) is associated with oxidative stress. Both iron (Fe) and oxygen are involved in the chemical reactions that lead to increased formation of reactive oxygen species. Oxidative reactions are prevented by antioxidants such as carotenoids. Objective: To study the differences in Fe status, carotenoid levels, healthy eating habits, and markers of inflammation and oxidative damage on proteins in subjects with severe COPD ± long-term oxygen therapy (LTOT) and lung-healthy control subjects. Methods: Sixty-six Caucasians with advanced COPD (28 with LTOT) and 47 control subjects were included. Questionnaires about general health, lifestyle, and dietary habits were answered. Lung function tests and blood sampling were performed. Results: COPD subjects (±LTOT) did not demonstrate increased oxidative damage, assessed by protein carbonylation (PC), while levels of soluble transferrin receptors (sTfRs) were slightly elevated. Soluble TfRs, which is inversely related to Fe status, was negatively associated with PC. Levels of carotenoids, total and β-cryptoxanthin, α- and β-carotenes, were significantly lower in COPD subjects, and their diet contained significantly less fruits and vegetables. Lutein correlated inversely with IL-6, lycopene correlated inversely with SAT, while β-carotene was positively associated with a Mediterranean-like diet. Conclusions: Fe could favor oxidative stress in COPD patients, suggesting a cautious use of Fe prescription to these patients. COPD subjects ate a less healthy diet than control subjects did and would, therefore, benefit by dietary counseling. COPD patients with hypoxemia are probably in particular need of a lycopene-enriched diet.

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Section: Discussionmentioning

confidence: 99%

Oxidant status, iron homeostasis, and carotenoid levels of COPD patients with advanced disease and LTOT

Kentson

Leanderson

Jacobson

et al. 2018

European Clinical Respiratory Journal

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“…As a result, seventeen further articles were sourced in which validation and/or reliability testing for the identified methods was described. The characteristics of the included studies (4,18, are described in Table 2. From the sourced articles, fifty-one pan-European studies in total were identified: thirty-five named projects and sixteen smaller projects (48,54,56,65,69,72,82,83,88,93,94,107,109,113,114,116) .…”

Section: Public Health Nutritionmentioning

confidence: 99%

“…Five assessed parents or caregivers (27,50,(85)(86)(87)102) . Four studies examined intake among older adults, namely MEDIS (MEDiterranean Islands Study) (78) , the Seven Countries Study (4,91,92) , SENECA (Survey in Europe on Nutrition and the Elderly; a Concerted Action) (43,90,148,149) and the 'Food in later life' study (68) . Nine studies assessed intake among children (27,30,37,50,85,86,101,116,120) in age ranges 2-9 years (37,118,119) , 3-6 years (95)(96)(97)(98)(99)(100)(101)(102)(103)(104)(105)(106) , 2-11 years (50) , 7-11 years (116) , 11 years (85) and 10-12 years (27) , and seven assessed intake among adolescents (32,50,109,110,…”

Section: Public Health Nutritionmentioning

confidence: 99%

“…A poor diet is associated with four major noncommunicable diseases: cancer, CVD, diabetes and respiratory disorders (1)(2)(3)(4) , which account for approximately 60 % of deaths globally per annum (5) . There is a growing body of research which highlights the benefits of fruit and vegetable (F&V) consumption, including the protective effect of F&V consumption on CVD (6,7) .…”

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confidence: 99%

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A systematic review of methods to assess intake of fruits and vegetables among healthy European adults and children: a DEDIPAC (DEterminants of DIet and Physical Activity) study

Riordan

Ryan

Perry

et al. 2016

Public Health Nutr.

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Evidence suggests that health benefits are associated with consuming recommended amounts of fruits and vegetables (F&V), yet standardised assessment methods to measure F&V intake are lacking. The current review aims to identify methods to assess F&V intake among children and adults in pan-European studies and inform the development of the DEDIPAC (DEterminants of DIet and Physical Activity) toolbox of methods suitable for use in future European studies.\ud A literature search was conducted using three electronic databases and by hand-searching reference lists. English-language studies of any design which assessed F&V intake were included in the review.\ud Studies involving two or more European countries were included in the review.\ud Healthy, free-living children or adults.\ud The review identified fifty-one pan-European studies which assessed F&V intake. The FFQ was the most commonly used (n 42), followed by 24 h recall (n 11) and diet records/diet history (n 7). Differences existed between the identified methods; for example, the number of F&V items on the FFQ and whether potatoes/legumes were classified as vegetables. In total, eight validated instruments were identified which assessed F&V intake among adults, adolescents or children.\ud The current review indicates that an agreed classification of F&V is needed in order to standardise intake data more effectively between European countries. Validated methods used in pan-European populations encompassing a range of European regions were identified. These methods should be considered for use by future studies focused on evaluating intake of F&V

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“…Unfortunately, rodent or human trials evaluating this possibility appear to be lacking, as does epidemiology focusing specifically on phase IIinducer foods. Nonetheless, a number of epidemiological studies have concluded that lung function is superior, and risk for COPD lower, in people who consume relatively large amounts of fruits and / or vegetables [5][6][7][8][79][80][81][82]. Hence, it is prudent to advise smokers to consume fruits and vegetables regularly and copiously, with emphasis on cruciferous and allium vegetables.…”

Section: Adjuvant Strategies Targeting Nrf2mentioning

confidence: 99%

DHA May Have a Profoundly Protective Impact on the Lungs of Smokers

Mf¹

2016

J Nutr Food Sci

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Evidence has accumulated over the last twenty years that smokers who frequently ingest fish are at lower risk for both chronic obstructive pulmonary disease (COPD) and lung cancer. Plasma phospholipid levels of DHA, but not EPA, have been reported to correlate inversely with risk for COPD in smokers, suggesting that DHA may be primarily responsible for the apparent protection afforded to lungs of smokers by fish consumption. Meanwhile, evidence is emerging that certain metabolites of DHA -including 4 -hydroxy hexenal (4-HHE), 17 -oxo -DHA, and resolvin D1 -can activate Nrf2 -mediated transcription of heme oxygenase -1 and other antioxidant / cytoprotective enzymes. Since the oxidant stress imposed by cigarette smoke exposure could be expected to promote peroxidation of membrane DHA and hence boost production of 4 -HHE, DHA in lung membranes may in effect up-regulate the protective feedback mechanism whereby oxidative stress provokes Nrf2 -mediated induction of cytoprotective enzymes. DHA can also give rise to the autacoid resolvin D1, which, via activation of a receptor, suppresses NFkappaB activation and the consequent production of pro-inflammatory cytokines. Resolvin D1 can also inhibit macrophage NADPH oxidase and promote an anti-inflammatory M2 phenotype in lung macrophages. Not surprisingly, inhalation of resolvin D1 has a marked anti-inflammatory impact on the lungs of mice exposed to tobacco smoke. These considerations help to rationalize the epidemiology linking fish consumption to lung health, and suggest that smokers who can't or won't quit their habit would be well advised to consume fish or DHA supplements regularly. Higher intakes of fruits and vegetables -likely in part because many of these contain Nrf2 -activating phytochemicals -likewise are associated with lower risk for COPD, and can be recommended for smokers.Keywords: COPD; Lung cancer; Fish; Docosahexaenoic acid (DHA); 4 -hydroxy hexenal; Nrf2; Resolvin D1 Fish Consumption May Protect Smokers from COPDLimited but nonetheless compelling epidemiology has linked heavy dietary consumption of fresh fish to marked decreases in risk for lung cancer and chronic obstructive pulmonary disease (COPD) among smokers. The first key evidence in this regard emerged in 1994. Shahar et al.[1] studied subjects enrolled in the prospective Atherosclerosis Risk in Communities (ARIC) study, who had received a dietary assessment and a physical exam including lung spirometry, and had been questioned regarding lung symptoms [1]. COPD was defined by three separate criteria: self -reported symptoms of chronic bronchitis, physician diagnosis of emphysema, and via spirometry (FEV1 < 65% of predicted value). When risk for COPD was compared between the first and fourth quartiles of estimated daily intake of eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA), relative risk for COPD in the fourth quartile (mean omega-3 intake 480 mg) after appropriate multivariate adjustments was found to be 0.66 (95% CI 0.52 -0.85), 0.31 (CI 0.18 -0.52), and 0.50 (CI 0.32...

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Diet and 20-year chronic obstructive pulmonary disease mortality in middle-aged men from three European countries

Cited by 110 publications

References 25 publications

Oxidant status, iron homeostasis, and carotenoid levels of COPD patients with advanced disease and LTOT

Oxidant status, iron homeostasis, and carotenoid levels of COPD patients with advanced disease and LTOT

A systematic review of methods to assess intake of fruits and vegetables among healthy European adults and children: a DEDIPAC (DEterminants of DIet and Physical Activity) study

DHA May Have a Profoundly Protective Impact on the Lungs of Smokers

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