Diet and asthma: vitamins and methyl donors

Han, Y.-Y.; Blatter, Joshua; Brehm, John M.; Forno, Erick; Litonjua, Augusto A.; Celedón, Juan C.

doi:10.1016/s2213-2600(13)70126-7

Cited by 54 publications

(62 citation statements)

References 117 publications

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“…Compared with obese women without asthma, obese women with asthma have increased macrophage infiltration, higher expression of leptin, and lower expression of adiponectin in adipose tissue (42). Other proposed mechanisms include presence of comorbidities (43,44), hormonal differences (45), dietary pattern changes (46,47), and alterations in insulin or arginine metabolism (48)(49)(50).…”

Section: Discussionmentioning

confidence: 99%

Adiposity, Fractional Exhaled Nitric Oxide, and Asthma in U.S. Children

Han

Forno

Celedón

2014

Am J Respir Crit Care Med

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Rationale: Whether allergic airway inflammation mediates the association between overweight or obesity and childhood asthma is unknown.Objectives: To examine adiposity, asthma, and fractional exhaled nitric oxide (FE NO ) in U.S. children.Methods: Cross-sectional study of indicators of adiposity or obesity, FE NO (a biomarker of eosinophilic airway inflammation), and asthma in 2,681 children aged 6-17 years in the 2007-2010 National Health and Nutrition Examination Survey. Adiposity measures included body mass index (BMI), percent body fat (PBF), and waist circumference (WC).Measurements and Main Results: BMI, PBF, and WC were associated with asthma among children with low FE NO (odds ratio, 1.54-1.68; P , 0.01), but not among children with increased FE NO . Among children without asthma, BMI, PBF, and WC were associated with higher FEV 1 and FVC, and lower FEV 1 /FVC. Among children with asthma and a high FE NO , all adiposity indicators were associated with decreased FEV 1 /FVC (b = 21.5% to 21.7% per z score) but not with FEV 1 or FVC. Higher BMI or PBF was associated with worse asthma severity or control in children with asthma and increased FE NO , but not in children with asthma and low FE NO . Similar results were obtained in a secondary multivariate analysis of overweight or obesity (defined as BMI >85th percentile) and asthma or indicators of asthma severity or control, stratified by FE NO level.Conclusions: Adiposity indicators are associated with asthma in children with low FE NO . Among children with asthma, adiposity indicators are associated with worse asthma severity or control in those with high FE NO .

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Section: Discussionmentioning

confidence: 99%

Adiposity, Fractional Exhaled Nitric Oxide, and Asthma in U.S. Children

Han

Forno

Celedón

2014

Am J Respir Crit Care Med

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“…Vitamin E has been proved to have the capabilities of rescuing allergen-induced inhibition of antioxidant enzymes, preventing the detrimental effects of air pollution as well as asthmatic features in asthma [3][4][5]. Furthermore, it has also been concluded that vitamin E supplements could improve clinical manifestations and pulmonary function tests in children with moderate asthma [6].…”

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confidence: 99%

Comparable Function of γ-Tocopherols in Asthma Remission by Affecting Eotaxin and IL-4

Xue

Zhang

et al. 2016

Adv Clin Exp Med

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Background. Bronchial asthma is one of the world's most common chronic disorders dangerous to human health. It has been hypothesized that the increased number of asthma sufferers may be due to changing antioxidant intake or vitamin deficiency. However, the influence of vitamins on asthma has rarely been considered. Objectives. The aim of this study was to explore the effects of γ-tocopherols, a specific form of vitamin E, on asthma remission together with the possible mechanism behind the process. Material and Methods. Eosinophil counting was applied to detect the total number of cells, eosinophils and lymphocytes. Meanwhile, HE staining was used for morphological detection. In addition, the eotaxin and IL-4 levels in the serum and bronchoalveolar lavage fluid were measured using ELISA technology. Results. The cell counting results showed that γ-tocopherols possesses the capability to reduce the number of eosinophils. Moreover, the exudation of inflammatory cells together with the hyperplasia of goblet cells was also found to experience significant inhibition when treated with γ-tocopherols. Furthermore, the high levels of eotaxin and IL-4 in the asthma group were evidently reduced under the treatment of γ-tocopherols which was comparable with hexadecadrol. Conclusions. γ-tocopherols can remit asthma by regulating the level of eotaxin and IL-4. Moreover, γ-tocopherols may be regarded as a potential candidate for asthma treatment after much deeper explorations (Adv Clin Exp Med 2016, 25, 4, 643-648).

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“…Epigenetic mechanisms, including DNA methylation [81,82], histone modifications, and noncoding RNAs, can affect gene transcription [83].…”

Section: Effects Of Diet On Epigenetic Regulation In Bronchial Asthmamentioning

confidence: 99%

Dietary or Supplementary Intake Modulates Inflammatory Response in Asthma Response in Asthma

Matsumura¹

2015

Glob J Allergy

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SummaryThe importance of diet and supplement intake in the onset and development of asthma has been advocated recently, and it may be important in the prevention and management of bronchial asthma. Long-chain n-3 polyunsaturated fatty acids (LCn3PUFAs), vitamins (Vit), choline, and probiotics may be candidates to reduce medication use and provide some protection from risk. Experimental studies of diet in bronchial asthma have demonstrated modification of pulmonary function and the immune system through mechanisms involving antioxidant effect, T-helper (Th) 2 and Th17 inhibition, tolerogenic regulatory T cell (Treg) function promotion, nuclear transcription factors and epigenetic regulation. Although studies in animal models have provided evidence of supportive effects of diet in asthma, there have been few longitudinal studies of dietary or supplement intake and asthma, and the available epidemiological data remain controversial and inconclusive.prevalence of asthma and allergy in their offspring [20]. Cord serum 25-Hydroxyvitamin D level was inversely associated with the risk of transient early wheezing by the age of 5 years, but no association was found with asthma [21]. Recent published data demonstrated that Vit D3 did not reduce the rate of first treatment failure or exacerbation in adults with persistent asthma and Vit D insufficiency, suggesting that therapeutic Vit D3 supplementation in patients with symptomatic asthma was not useful [22].

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Diet and asthma: vitamins and methyl donors

Cited by 54 publications

References 117 publications

Adiposity, Fractional Exhaled Nitric Oxide, and Asthma in U.S. Children

Adiposity, Fractional Exhaled Nitric Oxide, and Asthma in U.S. Children

Comparable Function of γ-Tocopherols in Asthma Remission by Affecting Eotaxin and IL-4

Dietary or Supplementary Intake Modulates Inflammatory Response in Asthma Response in Asthma

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