Dientamoeba fragilis: an emerging role in intestinal disease

Lagacé-Wiens, Philippe

doi:10.1503/cmaj.060265

Cited by 41 publications

(33 citation statements)

References 6 publications

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“…The prevalence of D. fragilis varies widely; however, with the advent of molecular diagnostics, rates of infection are reportedly higher than those of Giardia intestinalis (2). These statistics are consistent with other studies using nonmolecular methods (3)(4)(5)(6).…”

supporting

confidence: 86%

Description of Dientamoeba fragilis Cyst and Precystic Forms from Human Samples

Stark

Garcia²,

Barratt

et al. 2014

J Clin Microbiol

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supporting

confidence: 86%

Description of Dientamoeba fragilis Cyst and Precystic Forms from Human Samples

Stark

Garcia²,

Barratt

et al. 2014

J Clin Microbiol

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“…Although the mode of transmission remains unknown, based on high rates of coinfection with Enterobius vermicularis, it was suggested previously that infection occurs via the pinworm vector (25,153,191). Recent studies have discounted this idea (229). However, high rates of coinfection with other enteric pathogens and protozoa suggest that transmission occurs directly via the fecal-oral route (26,191).…”

Section: Dientamoeba Fragilismentioning

confidence: 99%

Enteric Protozoa in the Developed World: a Public Health Perspective

et al. 2012

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SUMMARY Several enteric protozoa cause severe morbidity and mortality in both humans and animals worldwide. In developed settings, enteric protozoa are often ignored as a cause of diarrheal illness due to better hygiene conditions, and as such, very little effort is used toward laboratory diagnosis. Although these protozoa contribute to the high burden of infectious diseases, estimates of their true prevalence are sometimes affected by the lack of sensitive diagnostic techniques to detect them in clinical and environmental specimens. Despite recent advances in the epidemiology, molecular biology, and treatment of protozoan illnesses, gaps in knowledge still exist, requiring further research. There is evidence that climate-related changes will contribute to their burden due to displacement of ecosystems and human and animal populations, increases in atmospheric temperature, flooding and other environmental conditions suitable for transmission, and the need for the reuse of alternative water sources to meet growing population needs. This review discusses the common enteric protozoa from a public health perspective, highlighting their epidemiology, modes of transmission, prevention, and control. It also discusses the potential impact of climate changes on their epidemiology and the issues surrounding waterborne transmission and suggests a multidisciplinary approach to their prevention and control.

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“…24,25 Prevalence rates range between 0% and 52% depending on the population studied and the method used for detection. 23,26 In Denmark, a general population prevalence rate of 13% has been reported.…”

Section: Introductionmentioning

confidence: 99%

Treatment of Dientamoeba fragilis in Patients with Irritable Bowel Syndrome

Engsbro

Stensvold²,

Nielsen³

et al. 2012

The American Society of Tropical Medicine and Hygiene

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Abstract. The role of Dientamoeba fragilis in irritable bowel syndrome (IBS) is incompletely known. We aimed to investigate whether eradication of D. fragilis alleviates symptoms in IBS. Twenty-five D. fragilis-positive IBS patients were treated with Metronidazole (MZ) or Tetracycline. The patients were mostly female (89%), and mean age (SD) was 35.1 (8.2) years. Microbiological response, evaluated 2 weeks post-treatment, was observed in 15 of 25 patients (60%), all by MZ. Clinical response, defined as adequate relief of symptoms, was observed in 7 of 22 patients (32%), all by MZ. In a logistic regression analysis, we found no significant association between clinical and microbiological response. This case study did not support our hypothesis of a simple association between D. fragilis and IBS. Some D. fragilis-infections were insufficiently treated by MZ. Further studies into the prevalence and effect of eradication of D. fragilis in IBS and into efficient treatments of D. fragilis are warranted.

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Dientamoeba fragilis: an emerging role in intestinal disease

Cited by 41 publications

References 6 publications

Description of Dientamoeba fragilis Cyst and Precystic Forms from Human Samples

Description of Dientamoeba fragilis Cyst and Precystic Forms from Human Samples

Enteric Protozoa in the Developed World: a Public Health Perspective

Treatment of Dientamoeba fragilis in Patients with Irritable Bowel Syndrome

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