Diels–Alder “click” chemistry for the cross-linking of furfuryl-gelatin-polyetheramine hydrogels

García‐Astrain, Clara; Gandini, Alessandro; Peña, C.; Algar, I.; Eceiza, Arantxa; Corcuera, María Ángeles; Gabilondo, Nagore

doi:10.1039/c4ra06122e

Cited by 74 publications

(70 citation statements)

References 42 publications

(46 reference statements)

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“…Moreover, in our previous work, the possibility of having a competitive Michael addition reaction during hydrogel formation with pending primary amino groups which remained unmodified was discarded. 25 Hydrogels were characterized by FT-IR spectroscopy (Fig. 7).…”

Section: Dsc Analysis Was Carried Out To Evaluate the Thermal Behaviomentioning

confidence: 99%

Hydrogel synthesis by aqueous Diels‐Alder reaction between furan modified methacrylate and polyetheramine‐based bismaleimides

García‐Astrain

Algar

Gandini

et al. 2014

J. Polym. Sci. Part A: Polym. Chem.

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A simple method for preparing cross-linked hydrogels in an aqueous medium is investigated using Diels-Alder (DA) "click" reaction, without employing a catalyst. A polymeric diene is first synthesized by the functionalization of poly(2-aminoethyl methacrylate) hydrochloride with furfural. Suited bisdienophiles are prepared by modification of Jeffamine V R ED of different molecular weights with maleic anhydride. Both precursors of the DA coupling are thoroughly characterized before their reactions. The ensuing hydrogels are analyzed in terms of their microstructure, swelling, and rheological behavior, as a function of the reaction conditions. The influence of the molecular weight of the cross-linker and the furan-to-maleimide ratio on the final properties of the hydrogels were also investigated.

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Section: Dsc Analysis Was Carried Out To Evaluate the Thermal Behaviomentioning

confidence: 99%

Hydrogel synthesis by aqueous Diels‐Alder reaction between furan modified methacrylate and polyetheramine‐based bismaleimides

García‐Astrain

Algar

Gandini

et al. 2014

J. Polym. Sci. Part A: Polym. Chem.

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show abstract

“…Recent studies carried out in our group indicated that gelatin can be successfully cross-linked using click chemistry for hydrogel formation [11]. In this sense, the main aim of this study is to further investigate the potential of these click hydrogels for drug delivery and to elucidate the effect of the network structure over the swelling and degradation kinetics.…”

Section: Introductionmentioning

confidence: 99%

Click gelatin hydrogels: Characterization and drug release behaviour

et al. 2016

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“…The ability of the gelatin chains to reorganize into a collagen-type helical structure is related to the hydrogen bonding capacity of the macromolecule. The attachment of the chromophore could alter the formation of the helical structure of gelatin, and, hence, reduce the degree of renaturalization of the samples [18]. In the second scan, which was performed after rapid cooling preventing the renaturalization, these transitions disappeared and only the glass transition temperature (T g ) was observed and slightly decreased for the modified samples.…”

Section: Resultsmentioning

confidence: 99%