Click gelatin hydrogels: Characterization and drug release behaviour

García‐Astrain, Clara; Guaresti, Olatz; González, Kizkitza; Santamaria‐Echart, Arantzazu; Eceiza, Arantxa; Corcuera, María Ángeles

doi:10.1016/j.matlet.2016.06.115

Cited by 35 publications

(22 citation statements)

References 15 publications

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“…In acid medium, where the -NH 2 groups of the chitosan would be protonated, more expanded networks were observed as could be expected. In the same trend of previously reported results for other polymeric hydrogels, changes in the pH could have an impact on the behavior of both the cross-linker and the polymer matrix, revealing the intramolecular structure of the hydrogels [25,34,35]. Surface roughness of hydrogels is an important issue as it could lead to better cell attachment on the hydrogel that is of crucial interest in some biomedical applications.…”

Section: Resultssupporting

confidence: 76%

“…And, ii) the amount [12,15], molecular weight [19] and hydrophilicity of the cross-linker [20][21][22][23]. At the same time, the resulting 3D microstructure of the hydrogels would also be a determining factor for the control of the swelling/shrinking ability and rate [24,25]. Pores homogeneously distributed within the hydrogel are expected to result in fast-responsive materials, turning the response-rate into a direct function of the microstructure.…”

Section: Introductionmentioning

confidence: 99%

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Reversible swelling behaviour of Diels–Alder clicked chitosan hydrogels in response to pH changes

Guaresti¹,

García‐Astrain²,

Urbina³

et al. 2019

Express Polym. Lett.

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Poly(propylene oxide)-poly(ethylene oxide)-poly(propylene oxide) (PPO-PEO-PPO) based bismaleimide (BMI) was employed as cross-linking agent for the synthesis of pH-sensitive clicked hydrogels by Diels-Alder (DA) reaction with furan-grafted chitosan in aqueous solution. The effect of the surrounding pH over the microstructure and the swelling ability of the hydrogels was evaluated depending on the initial composition. The results suggested that the hydrogels maintained the characteristic responsive properties of the original biopolymer even after the cross-linking reaction. The different macromolecular networks remarkably affected the final properties, especially when referring to pH-swelling sensitiveness and hydrogel porosity. In addition, the swelling parameters revealed that the hydrogels presented large liquid absorption capacity, showing excellent recovery properties and responsiveness at different pHs. The promising features of the ensuing hydrogels made them suitable as targeted pH-sensitive drug delivery systems.

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Section: Resultssupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Reversible swelling behaviour of Diels–Alder clicked chitosan hydrogels in response to pH changes

Guaresti¹,

García‐Astrain²,

Urbina³

et al. 2019

Express Polym. Lett.

Self Cite

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“…On completion of dynamic swelling studies, same samples were allowed to swell continuously until a constant weight was achieved (García-Astrain et al., 2016 ), equilibrium swelling ratio was calculated using Equation (2) . where W h represents the weight of swollen gel at equilibrium and W d represents the weight of dry gel before swelling.…”

Section: Methodsmentioning

confidence: 99%

“…All experiments were carried out in triplicates and porosity was calculated using Equation (5) . where M 1 and M 2 represent the mass of hydrogel disc before and after dipping in ethanol respectively, ρ represents the density of absolute ethanol and V is the hydrogel volume (García-Astrain et al., 2016 ).…”

Section: Methodsmentioning

confidence: 99%

“…To overcome this problem, polymer-based controlled release dosage form became the subject of interest for the researchers (Joner et al., 2008 ). A polymer that shows a sudden shift in its physical characteristics when its external environment changes is known as a stimuli-sensitive or smart polymer (García-Astrain et al., 2016 ). They are also known as intelligent polymers because small changes occur in response to an external trigger until a critical point is reached, and they have the ability to return to their original shape after trigger is removed (Gupta et al., 2002 ).…”

Section: Introductionmentioning

confidence: 99%

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Pharmacokinetic evaluation of quetiapine fumarate controlled release hybrid hydrogel: a healthier treatment of schizophrenia

et al. 2018

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The current study aimed to rationally develop and characterize pH-sensitive controlled release hydrogels by graft polymerization of gelatin (Gel) and hydroxypropyl methyl cellulose (HPMC) in the presence of glutaraldehyde (GA) using quetiapine fumarate for the treatment of schizophrenia. The prepared hydrogels discs were subjected to various physicochemical studies including: swelling, diffusion, porosity, sol-gel analysis, Fourier transform infrared spectroscopy, differential scanning calorimetry, and scanning electron microscopy. Three different pH values (1.2, 6.8 and 7.4) were used to determine shape, transition, and controlled release behavior of prepared hydrogels. Various kinetic models including zero order, first order, Higuchi model and Power Law equation were applied on drug release data. The optimized hydrogels were subjected to in vivo studies using albino rabbits. Swelling and release results were found to be insignificant (p < .05) evidencing that there was no significant difference in swelling and drug release rate of hydrogels in different pH mediums. Swelling, porosity, gel-fraction, and drug released (%) were found to be dependent on concentrations of Gel, HPMC, and GA. Kinetic models revealed that QTP-F release followed non-Fickian diffusion. In-vivo studies contributed significantly higher plasma QTP-F concentration (C max), time for maximum plasma concentration (T max), area under the curve (AUC0–inf) and half-life (t 1/2) as 18.32 ± 0.50 µg/ml, 8.00 ± 0.01 hrs, 6021.2 ± 5.09 µg.hrs/ml and 10.06 ± 0.43 hrs, respectively, for test-hydrogels when compared to reference market brand (Qusel® 200 mg, Hilton Pharma, Karachi, Pakistan) QTP-F tablets. It might be concluded that QTP-F loaded pH-sensitive hydrogels were developed successfully with reduced dosing frequency for schizophrenia.

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Advances in Gelatin Bioinks to Optimize Bioprinted Cell Functions

Asim

Tabish

Liaqat

et al. 2023

Adv Healthcare Materials

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Gelatin is a widely utilized bioprinting biomaterial due to its cell‐adhesive and enzymatically cleavable properties, which improve cell adhesion and growth. Gelatin is often covalently cross‐linked to stabilize bioprinted structures, yet the covalently cross‐linked matrix is unable to recapitulate the dynamic microenvironment of the natural extracellular matrix (ECM), thereby limiting the functions of bioprinted cells. To some extent, a double network bioink can provide a more ECM‐mimetic, bioprinted niche for cell growth. More recently, gelatin matrices are being designed using reversible cross‐linking methods that can emulate the dynamic mechanical properties of the ECM. This review analyzes the progress in developing gelatin bioink formulations for 3D cell culture, and critically analyzes the bioprinting and cross‐linking techniques, with a focus on strategies to optimize the functions of bioprinted cells. This review discusses new cross‐linking chemistries that recapitulate the viscoelastic, stress‐relaxing microenvironment of the ECM, and enable advanced cell functions, yet are less explored in engineering the gelatin bioink. Finally, this work presents the perspective on the areas of future research and argues that the next generation of gelatin bioinks should be designed by considering cell–matrix interactions, and bioprinted constructs should be validated against currently established 3D cell culture standards to achieve improved therapeutic outcomes.

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Click gelatin hydrogels: Characterization and drug release behaviour

Cited by 35 publications

References 15 publications

Reversible swelling behaviour of Diels–Alder clicked chitosan hydrogels in response to pH changes

Reversible swelling behaviour of Diels–Alder clicked chitosan hydrogels in response to pH changes

Pharmacokinetic evaluation of quetiapine fumarate controlled release hybrid hydrogel: a healthier treatment of schizophrenia

Advances in Gelatin Bioinks to Optimize Bioprinted Cell Functions

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