Dielectrophoresis: From Molecular to Micrometer-Scale Analytes

Kim, Daihyun; Sonker, Mukul; Ros, Alexandra

doi:10.1021/acs.analchem.8b05454

Cited by 100 publications

(106 citation statements)

References 226 publications

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“…A summary of these diverse electrokinetic particle manipulations (experiments only) is presented in Table . One can see from this table that the current demonstrations of DC or DC‐biased AC electrokinetic manipulations have been very limited for nanoparticles because of the strong size dependence of the involved electrical forces (see, e.g., and along with the papers cited therein). Very high electric fields (even just locally) are often necessary in these demonstrations .…”

Section: Discussionmentioning

confidence: 99%

“…One can see from this table that the current demonstrations of DC or DC‐biased AC electrokinetic manipulations have been very limited for nanoparticles because of the strong size dependence of the involved electrical forces (see, e.g., and along with the papers cited therein). Very high electric fields (even just locally) are often necessary in these demonstrations . It is therefore fundamentally interesting and practically useful to understand if any other nonlinear effects may evolve under such harsh conditions such as the reported ultrafast electrophoresis and the modified Helmholtz–Smoluchowski slip velocity .…”

Section: Discussionmentioning

confidence: 99%

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Recent advances in direct current electrokinetic manipulation of particles for microfluidic applications

Xuan

2019

Electrophoresis

101

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Microfluidic devices have been extensively used to achieve precise transport and placement of a variety of particles for numerous applications. A range of force fields have thus far been demonstrated to control the motion of particles in microchannels. Among them, electric field‐driven particle manipulation may be the most popular and versatile technique because of its general applicability and adaptability as well as the ease of operation and integration into lab‐on‐a‐chip systems. This article is aimed to review the recent advances in direct current (DC) (and as well DC‐biased alternating current) electrokinetic manipulation of particles for microfluidic applications. The electric voltages are applied through electrodes that are positioned into the distant channel‐end reservoirs for a concurrent transport of the suspending fluid and manipulation of the suspended particles. The focus of this review is upon the cross‐stream nonlinear electrokinetic motions of particles in the linear electroosmotic flow of fluids, which enable the diverse control of particle transport in microchannels via the wall‐induced electrical lift and/or the insulating structure‐induced dielectrophoretic force.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Recent advances in direct current electrokinetic manipulation of particles for microfluidic applications

Xuan

2019

Electrophoresis

101

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“…[9] Being able to characterize quantitatively the DEP response of such small NPs is important for nano-assembly of NPs using DEP fields, [43][44][45] and for bioanalytical applications of NPs in combination with DEP. [46] The second important demonstration in this work is the disentanglement of the extinction spectra of two differently sized gold NPs mixed in the same sample by DEP-modulated spectroscopy. The spectrotemporal data generated through DEP modulation of the NP concentration in the spectroscopic observation volume can be submitted to chemometric multicomponent analysis, [31,32] as demonstrated in the Supporting Information.…”

Section: Resultsmentioning

confidence: 94%

Dielectrophoretically Modulated Optical Spectroscopy of Colloidal Nanoparticle Solutions in Microfluidic Channels

Midelet

Werts

2020

Part & Part Syst Charact

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Optical spectroscopic techniques (e.g., extinction, scattering, and fluorescence spectroscopies) are important for the analysis of colloidal solutions of nanoparticles (NPs). They are routinely applied to plasmonic and quantum-dot NP samples assuming that these contain a single population of particles with modest size and shape dispersity. However, these spectroscopic techniques become less effective when the sample is a mixture of particles with different sizes, shapes, or composition. Here, an original microfluidic method is proposed for the optical spectroscopic analysis of colloidal NP solutions that combines periodic trapping of NPs by dielectrophoresis (DEP) with in situ optical extinction spectroscopy. The periodic trapping leads to modulation of the continuously monitored optical spectrum depending on the DEP properties of the NPs. DEP-modulated spectroscopy is demonstrated using colloidal gold NPs as small as 40 nm diameter. It is found that the DEP modulation is significantly enhanced when employing suitable microfluidic flow over a multielectrode array. Finally, it is shown that the method can identify and characterize the NP species simultaneously present in a mixture of 40 and 80 nm gold NPs, opening the way toward optical spectroscopic analysis of higher complexity NP mixtures through the combination of the DEP-modulated spectroscopy with chemometric methods.

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“…Most recently, Kim et al. reviewed both the fundamentals and the applications of DEP technique for analytes in a size range from microscale cells to biomolecules.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in dielectrophoresis‐based cell viability assessment

et al. 2020

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Recent advances in dielectrophoresis-based cell viability assessmentDielectrophoresis (DEP) is a non-destructive, accurate, and label-free cell manipulating technique and DEP applications have been found in various fields. Assessment of cell viability is one of the important applications and many investigations have been reported. In this paper, cell polarization and its modeling, some key parameters employed for living/dead cell separation, as well as electrode configurations are reviewed. Focus is given to the latest development of DEP devices employed for the assessment of cell viability. Experimentally determined factors for separating living/dead cells, such as the conductivity of suspending medium and the frequency of applied electric field, are summarized. The future directions and potential challenges in this field are also outlined. Theory of cell DEPThe fundamentals of DEP were systematically reviewed in the past [35,36]. In this section, we only focus on the theory concerning cellular DEP. Based on the spherical particle model, single-shell model and multi-shell model of biological cells are extended. Color online: See the article online to view Figs. 1-7 in color. J. Zhang et al. Electrophoresis 2020, 41, 917-932

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Dielectrophoresis: From Molecular to Micrometer-Scale Analytes

Cited by 100 publications

References 226 publications

Recent advances in direct current electrokinetic manipulation of particles for microfluidic applications

Recent advances in direct current electrokinetic manipulation of particles for microfluidic applications

Dielectrophoretically Modulated Optical Spectroscopy of Colloidal Nanoparticle Solutions in Microfluidic Channels

Recent advances in dielectrophoresis‐based cell viability assessment

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