Dielectrophoresis and antibody mediated selective capture of microorganisms in micro-fluidic biochips

Li, H.; Li, Yang; Akin, Demir; Geng, Tao; Bhunia, Arun K.; Huang, Tom T.; Ladisch, Mike; Bashir, Rashid

doi:10.1109/sensor.2005.1497418

Cited by 1 publication

(1 citation statement)

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“…In order to shorten the working periods, many detecting methods of Salmonella have been rapidly developed and commercialized. Recently, there have been several studies using dielectrophoresis methods to detect biological cells [1][2][3][4][5][6]. In this study, we primarily introduce a method using antibody-coated nanoparticles to specifically attach the target bioparticles.…”

Section: Introductionmentioning

confidence: 99%

Development of a biochip using antibody-coated gold nanoparticles to detect specific bioparticles

Huang

Hou

Fang

et al. 2008

J Ind Microbiol Biotechnol

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This study developed a method of detecting bioparticles such as Salmonella that exist in the biological samples. The method employed a substrate with interlaced comb-like electrodes into which the mixtures of biological samples and antibody-coated gold nanoparticles were added. The alternative signals with appropriate frequency bands were then conducted into the comb-like electrodes to change the dielectrophoresis force. The gold-modified Salmonella can be adsorbed on the edges of the electrodes and isolated from various biological samples. The impedance of the adsorbed Salmonella on the edges of the electrodes was measured and comparison of the impedance between the electrodes with and without Salmonella can quantify the amount of the adsorbed Salmonella.

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