Dielectric studies of metal complexes of thiourea crystals for electro-optic modulation

Dhumane, N. R.; Hussaini, S. S.; Nawarkhele, V. V.; Shirsat, M.D.

doi:10.1002/crat.200510691

Cited by 34 publications

(16 citation statements)

References 10 publications

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“…The overestimation of value in the theoretical spectra is due to anharmonicity in the real system. Efficient NLO crystals have an optical transparency lower cutoff wavelength between 200 and 400 nm [14]. From the UV-vis spectral analysis it is clear that the cut off wavelength is at 236 nm and there is no significant absorption in the UV region thereby confirming the advantages of the crystals, the large transmission in the entire region and short cutoff wavelength enable the crystals to be useful for second harmonic generation.…”

Section: Optical Absorption Studiesmentioning

confidence: 79%

Synthesis, growth, molecular structure and spectral studies of 1,3 diglycinyl thiourea by density functional method

Kumar¹,

Kanagadurai

Mani³

et al. 2015

Optik

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Section: Optical Absorption Studiesmentioning

confidence: 79%

Synthesis, growth, molecular structure and spectral studies of 1,3 diglycinyl thiourea by density functional method

Kumar¹,

Kanagadurai

Mani³

et al. 2015

Optik

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“…A series of thiourea derivatives bearing ibuprofen moiety N-2-(4-(2-methylpropyl)phenyl)propionoyl-N´-(2´-bromophenyl) thiourea (1), N-2-(4-(2-methylpropyl)phenyl)propionoyl-N´-(2´-chlorophenyl) thiourea (2), N-2-(4-(2-methylpropyl)phenyl)propionoyl-N´-(3´,4´-dichlorophenyl) thiourea (3) and their corresponding complexes of Co(ΙΙ) (4-6), Ni(ΙΙ) (7-9), Pb(ΙΙ) (10)(11)(12) and Cu(Ι) (13)(14)(15) were synthesized and characterized by FTIR and 1 HNMR spectroscopy. The synthesized thiourea derivatives were evaluated for Jack bean urease inhibition activity.…”

Section: Resultsmentioning

confidence: 99%

“…N, N'-Disubstituted thioureas are of great importance due to their ability to concentrate and separate the toxic metals. Therefore metal complexes of aroyl thiourea are excellent candidates to use as lixiviant, chromogenic ionophore towards fluoride ion detection, in opto-electric modulation, for developing polymer membrane ion-selective e-mail: amaramumtaz@ciit.net.pk electrode and also exhibit great anti-bacterial, anti-fungal, anti-tumor, antiviral, anti-mycobacterial and also posses urease inhibition activities (Arslan et al 2006;D'Cruz OJ 2003;Del CR 2002;Dhumane NR 2006;Moro AC 2009;Sun MZ 2008;Tremblay L 1996). Thioureas and their derivative are considered as very effective inhibitory active agents against the urease enzyme (Aslam MA 2011).…”

mentioning

confidence: 99%

Synthesis, Characterization and Urease Inhibition Studies of Transition Metal Complexes of Thioureas Bearing Ibuprofen Moiety

Mumtaz

Arshad

Saeed

et al. 2018

J. Chil. Chem. Soc.

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Starting from ibuprofen, a non-steroidal anti-inflammatory drug, N,N'-disubstituted thiourea derivatives were synthesized by refluxing the acid chloride of ibuprofen with potassium thiocyanate followed by substituted anilines to get N-2- (4-(2-methylpropyl) phenyl)propionoyl-N´-(2´-bromophenyl) thiourea (1), N-2-(4-(2-methylpropyl)phenyl)propionoyl-N´-(2´-chlorophenyl) thiourea (2) and N-2-(4-(2-methylpropyl)phenyl)propionoyl-N´-(3´,4´-dichlorophenyl) thiourea (3).Metal complexes (4-15) of (1-3) were synthesized by refluxing it with one equivalence salts of Co (ΙΙ), Ni(ΙΙ), Pb(ΙΙ) and Cu(Ι). Structures of all the synthesized thiourea ligands and their metal complexes were determined by FTIR and 1 HNMR spectroscopy. Shift in stretching frequency in FTIR and resonance frequency in 1 HNMR spectroscopic data suggested that the ligands and metal are coordinated to afford respective metal complexes M[L] n . The synthesized compounds were tested against urease enzyme and the results were compared with standard thiourea, as positive control. Most of the investigated compounds showed potential inhibitory activity against Jack bean urease. Compound 5 was found to be the most potent urease inhibitor with IC 50 of 14.6 µM, whereas compounds 8, 11 and 12 possessed potent urease inhibition. The tested compounds can be taken as lead molecules for gastrointestinal ulcer therapy.Key words: Amides, Thioureas, Metal complexes, Ibuprofen, Urease. INTRODUCTIONUrease (urea aminohydrolase E.C. 3.5.1.5) is nickel containing metalloenzyme which belongs to the super family of amidohydrolases and phosphotriestreases, responsible for the hydrolytic decomposition of urea (Holm 1997). It was the first enzyme which crystallized from the plant source Canavalia ensiformis and was also the first protein containing nickel in the active site (Saeed et al. 2014;Saeed et al. 2013). Because of these characteristics urease is considered as a paradigm in the development of inorganic biochemistry. Urease catalyses the hydrolysis of urea in different plants, algae, fungi, and microorganisms to produce ammonia and carbamate (Mobley HL 1989). Enzyme catalysed hydrolysis-process occurred at a rate of approximately 10 14 times the rate of the unanalyzed reaction and considered as the final step of nitrogen metabolism in all living organisms. Different types of urease enzymes can be isolated from bacteria, fungi, algae and plants but enzymatic activity is same due to the occarance of the same order of amino acid (Bacanamwo M 2002;Benini S 1999). Urease activity due to infectious microorganism is the major reason for many deceases in humans such as development of infection stones, pyelonephritis, stomach and peptic ulcer, urinary catheter encrustation, and hepatic com (Gripenberg-Lerche C 2000; Mobley et al. 1995;Mobley HL 1989). To overcome these diverse types of problems, urease inhibitors have received special attention over the past few years. These inhibitors generally divided into two classes, substrate structural analogs like hydroxamic acid (Ko...

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“…The FTIR spectrums of pure BTCC and 2 mol% glycine doped BTCC were recorded using Perkin Elmer Spectrum FTIR spectrometer by KBr pallet technique in the range 450-4000 cm -1 and shown in figure 2 and 3 respectively. The characteristic vibrational frequencies of the functional groups of 2 mol% glycine doped BTCC have been compared with pure BTCC and thiourea [18,27,28]. The comparison of characteristic vibrational frequencies has been tabulated in table 1.…”

Section: Resultsmentioning

confidence: 99%

Growth and characterization of glycine doped bis thiourea cadmium chloride single crystal

Dhumane

Hussaini

Dongre

et al. 2009

Cryst. Res. Technol.

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Single crystal of 2 mol% glycine doped Bis Thiourea Cadmium Chloride, a semi organic nonlinear optical material has been grown by slow evaporation technique. Good quality single crystal with dimension 14 × 12 × 5 mm3 was harvested after 35 days. The influence of amino acid glycine was studied for 1, 2 and 3 mol% glycine doped Bis Thiourea Cadmium Chloride by Kurtz and Perry powder second harmonic generation test and compared with pure Bis Thiourea Cadmium Chloride which confirms the enhancement of second harmonic generation property of glycine doped Bis Thiourea Cadmium Chloride. The large enhancement was found for 2 mol% glycine doping. The grown crystal was characterized by various characterizations viz. single crystal X‐ray diffraction, energy dispersive X‐ray (EDAX), Fourier Transform Infrared Spectroscopy (FTIR) analysis, UV‐visible absorption, thermo gravimetric analysis (TGA). (© 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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Dielectric studies of metal complexes of thiourea crystals for electro-optic modulation

Cited by 34 publications

References 10 publications

Synthesis, growth, molecular structure and spectral studies of 1,3 diglycinyl thiourea by density functional method

Synthesis, growth, molecular structure and spectral studies of 1,3 diglycinyl thiourea by density functional method

Synthesis, Characterization and Urease Inhibition Studies of Transition Metal Complexes of Thioureas Bearing Ibuprofen Moiety

Growth and characterization of glycine doped bis thiourea cadmium chloride single crystal

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